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8 Cards in this Set
- Front
- Back
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M. tuberculosis
• Morphology |
aerobic, acid-fast Bacilli ( rods)
seen with Ziehl-Neelson or Kinyoun Thick PG wall with LAM |
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M. tuberculosis
• Transmission • Epidemiology |
Tx: Form droplet nuclei which can dry and pathogen can be inhaled
Also ingested in raw milk As few as 10 bacilli infect Epi: Poor countries, immunocomprimised, young children |
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M. tuberculosis
• Pathogenesis/Virulence Factors |
Path: facultative intracellular organism --> ingestion by M0 --> granuloma formation
V Factrs: --Cord: giant cell formation --Sulfitides: inhibit phag-lys fusion --LAM: inhibit M0 activation |
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M. tuberculosis
• Clinical Manifestations |
Chronic pneumonia w insidious onset
Fatigue/fvr/wht loss chronic cough w blood tinged sputum Can affect other organs |
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M. tuberculosis
• Diagnosis |
Culture for definitive dx
--Lowenstien-Jensen or Middlebrook media (1-3 wks) Production of Niacin unique to species Nucleic acid |
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M. tuberculosis
• Treatment • Prevention and Control |
Rx: 3, 4, or 5 drugs due to resistance
Prev: isonazid to prevent progression of latent infection --vaccine used abroad, variable efficacy PPD |
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M. avium-intracellulare
• Transmission • Epidemiology • Clinical Manifestations • Treatment |
Trans: Not P2P, ubiquitous in soil/H2o
Epi: severely immunocomprimised, Clinical: non-pulm dz RX: difficult to treat, highly resistant |
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Nocardia (asteriodes, brasiliensis, cavae)
--Morphology --Pathogenisis --Treatment |
Morph: G+, part acid fast, filaments which fragment to form baciliary or coccoid forms
Path: Multiple abcesses w infilt. of PMNs & central necrosis--NO GRANULOMAS Attacks brain, kidney, skin inhibits phag-lys fusion DX: microscopically, look for filaments, incubate warm aerobic medium RX: sulfonamides |
