Takayasu Arteritis

Front 1

takaysu arteritis Was Described By Which Person ?????

Back 1

Takaysu ( 1908)

Front 2

Which Arteries are involved in takaysu arteritis ???

Back 2

Medium Arteries + Larger Arteries

1-it classically involves AORTIC ARCH + BRANCHES --> causes weak/no pulse in upper limbs + numbness/coldness on fingers + ocular distubances + neurological deficits

if involves ROOT OF AORTA --> dilation --> aortic valve insufficiency

2- in 1/3 cases...REMAINDER OF AORTA + BRANCHES --> cause claudication of legs

3-In 1/2 cases...PULMONARY ARTERIES --> cause pulm HTN

4-renal a

4-coronary a --> cause MI

Front 3

which type of inflammation is there in takaysu arteritis ???

Back 3

CHRONIC

GRANULOMATOUS

Front 4

OTHER NAME of takaysu arteritis ??

Back 4

pulsless disease

Front 5

why takaysu arteritis is called pulseless disease????

Back 5

bcoz in it, therz marked WEAKENING of the pulses in the upper extremities

Front 6

Clinical Features takaysu arteritis ???

Back 6

1- OCULAR DISTURBANCES (principally)

2-pulseless upper extremities

Front 7

cause of weakening/loss of pulse in takaysu arteritis ???

Back 7

vasculitis + later fibrous thickening of aorta esp aortic arch n its branches --> narrownig or virtul obstr of origins or more distal portions --> weak or no pulse in upper extremity

Front 8

sex prevalence in takaysu arteritis ??

Back 8

seen predominantly in F < 40

Front 9

cause of takaysu arteritis ??

Back 9

unknown

Front 10

pathogenesis takaysu arteritis ????

Back 10

unknown..AUTOIMMUNITY ??

Front 11

RACIAL PREVALENCE takaysu arteritis ??

Back 11

more in japanese..

a high freq of HLA haplotype
A-24-B52-DR2 ..found in japanese..but not in other populations.....

Front 12

a pt comes to you and presents with
MARKED HYPOTENSION,
WEAKER PULSES IN UPPER LIMBS,
NORMAL PULSES IN LOWER LIMBS,
FINGERS ARE COLD AND INSENSITIVE (numbnes),
he is also complaining of visual defects...what is ur dioagnosis n why???

Back 12

takayasu arteritis..

2 most imp features are pulseless upper limb n ocular disturbances

Front 13

is there hypo or hyper-tension in takayasu arteritis??

Back 13

both r written in robbins

Front 14

name ocular disturbances in takayasu ??

Back 14

VISUAL DEFECTS

RETINAL HEMORRHAGES

TOTAL BLINDNESS

Front 15

do the pt show neurological defects in takaysu arteritis ??

Back 15

yes

Front 16

what happens to fingers in takaysu arteritis ??

Back 16

coldness / numbness

cause?? u think

Front 17

how takaysu arteritis progresses?? wts the course ??

Back 17

variable

in some pts, it progreses rapidly

in others, therz a QUIESCENT STAGE .. REACHED IN 1-2 YEARS --> LONG TERM SURVIVAL OFCOURSE

Front 18

NAME 2 s/s THAT MAY BE PRESENT EVEN IN QUIESCENT STAGE of takaysu arteritis ?/

Back 18

visual defects

neurological defects

Front 19

gross morphology takaysu arteritis ???

Back 19

1- irregular thickening of wall
2-intimal wrinkling
3-intimal thickening
4-minimal residual lumen

Front 20

histopatho takaysu arteritis ??

Back 20

varies FROM

1-mononuclear infiltrate in adventitia
2-perivascular cuffing of vasa vasorum

TO

3-intense monuclear infiltr in media.nearly destroyed media
4-granulomatous infl
5-giant cells of granuloma (v much)
6-patchy necrosis of media(DD temporal arteritis..v difficult 2 differentiate)

take follwoing as a rule

AGE FACTOR= active giant cell lesions of aorta in young --> takayasu arteritis

7-post-therapy wid steroids or after long time..collagenous fibrosis..of all layers esp intima

8-lymphocytic infiltr

Front 21

factor used 2 distinguish betwen active giant cell lesions of aorta??

Back 21

AGE
young --> takayasu

Front 22

what histopathological changes take palce in arteries with takaysu arteritis after taking treatment or when the disease remains untreated for a long period of time ??

Back 22

1-collagenous fibrosis..of all layers esp intima

2-lymphocytic infiltr