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14 Cards in this Set
- Front
- Back
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What are the 4 stages of heart dz
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risk factors
ht dz with no sx prior or current ht failure sx refractory ht failure sx |
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what drugs do you use in each stage of ht failure
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tx risk fctrs, ACE-i
ACE-i, beta block ACE-i, beta block, diuretic, digi Palliative care, ht tx |
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Digitalis MOA
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inotropic, naturesis, neurohormonal
dec norepi, dec periph nerv sys, dec renin-angio, inc vagal tone, |
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How does dig inc contractility
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inhibitd NaK pump causing more calcium to be stored in myocytes
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How well does dig improve survival rates
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It DOESN'T, ha ha ha
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When should you give dig
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after ACE-i, beta, diuretic fail
in combo with ACE-i, diuretic when sx persist Atrial fib to slow AV cond |
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When shouldn't you give dig
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dig toxicity
AV nodal dysfnx PVC and VT hypokalemic - causes arrhythmia WPW with atrial fib |
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Describe the therapeutic window for dig
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very narrow, titrate levels
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Where, biochemically, do Bipyridines work
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block degradation of cAMP, thereby stimulating phosphorylation of Ca channels
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Where, biochemically, do catecholamines work (in the heart)
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beta arenergic rcptrs that stimulate cAMP production
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Which direction does the pressure volume curve of CHF shift when dig is given
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Up and left
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what is BiDil
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combo drug, isosorbide dinitrate and hydralazine
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Why is BiDil special
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approved for tx of HF in blacks
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Pt presents co yellow-green halos. Whats the dx
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Dig toxicity
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