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22 Cards in this Set
- Front
- Back
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Tx Polycystic Ovarian Syndrome
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Want to normalize androgen/estrogen with oral contraceptives, spironolactone (non FDA approved), clomiphene
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Clomiphene works via?
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anti-estrogen at hypothalamus to increase GnRH
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Goal of treatment of endometriosis
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To cause atrophy of the abnormal uterine tissue by inhibiting FSH and LH and estrogen
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Tx endometriosis
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Oral contraceptives (combo or progestin only), GnRH analogue (Goserelin, Leuprolide), Danazole
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Danazole is a ? side effects?
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Danazole is a synthetic derivative of 17ethinyl testosterone
Side effects: hirsutism, oily skin, acne, menstrual irregularities |
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Hyperprolactinemia caused by? results in?
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usually caused by prolactin-secreting tumors and causes galactorrhea, amenorrhea, impotence, infertility
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Tx hyperprolactinemia?
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DA agonist
Bromocriptine Pergolide Cabergoline Quinagolide |
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Naturally occuring androgens?
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Testosterone
Dihydrotestosterone |
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Synthetic androgens?
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Mehtyltestosterone
Fluoxymestrone Oxandrolone |
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Androgenic receptor mediated physiologic properties of androgen
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Testosterone: internal genitalia, skeletal muscle, erythropoesis
DHT: external genitalia, hair |
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Estrogen receptor mediated physiologic actions of androgens?
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Epiphyses, libido
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Therapeutic uses of androgens?
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Male inferility
Loss of gonadal function Osteoporosis HRT combined with estrogens Inoperable breast cancer Offset weight loss |
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Therapeutic uses of anti-androgens?
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Metastatic prostate cancer
To treat hirsutism in women |
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Formulations of androgens?
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Oral
Injection Transdermal |
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Why is oral androgen not used as much?
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Testosterone is readily metabolized in liver so must be alkylated or methylated
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Two AR antagonists:
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Flutamide and Bicalutamide
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SARMs?
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quinolone derivatives
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5alpha reductase inhibitors
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Finasteride
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Side effects of androgens
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Prostatic of enlargment
Prostate cancer Gynecomastia Acne Erythrocytosis (rare) Increased Na/H2O retention Hepatic effects |
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Hepatic effects of androgens monstly seen with?
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7 alkylated androgens
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Tx for benign prostatic hypertrophy
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DHT inhibitors: (5alpha reductase) Finasteride, Dutasteride
GnRH analogue: Goserelin Leuprolide |
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Hormone tx for prostate cancer:
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GnRH antagonist: Abarelix
GnRH analogue: Goserelin, Leuprolide Estrogens or Profesterone Anti-androgens: Flutamide, Biclutamide |
