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20 Cards in this Set
- Front
- Back
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therapy for breast cancer
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anti-estrogen therapy - (tamoxifen = estrogen receptor antagonist) -therapy acting via nuclear receptor |
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promote skele growth in males w/ inadequate androgen secretion -unapproved use in athletes to increase lean body mass |
androgen therapy -therapy acting via nuclear receptors |
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block androgen receptors in metastatic prostate cancer |
anti-androgen therapy (type of therapy acting via nuclear receptors) -finasteride and flutamide |
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name for pdk1 |
phosphoinositide-dependent kinase |
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pdk1 activates ? |
pkb (akt) and pkc |
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P1-3k stands for? |
phosphoinositide-3 kinase |
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pkb inhib apop functions? |
phos and inactivation of pro-apo proteins Bad and Caspase-9 |
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akt activation stim glucose imp |
via inserting glut4 into plasma membrane |
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pkc activation (RTKs act) needs: |
1. phos by pdk 2. phosphatidylserine in plas mem 3. Ca2+ 4. DAG 2-4 are positive allosteric effectors |
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release of ca from er: |
1.ip3-gated ca2+ channel in er 2. ryanodine receptor (in sarcoplasmic reticulum ) (skele muscles) |
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release of ca2+ in cytosol through extracellular compartment: |
voltage-gated Ca2+ channel Na+/Ca2+ exchanger |
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pkb and metab? |
stim glycogen synth and glycolysis inhib of gluconeogensis |
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primary contributor to cancer? |
accumulation of oxidative damage to chromosomal DNA |
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loss of cell regulation |
cell misbehavior |
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cyclins are? |
allosteric activators of cyclin-dependent kinase |
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cdks do what? |
phos cell cycle proteins to start mitosis |
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Rb stands for? what does it do? |
-retinoblastoma protein -inhibits (non-phost state) synthesis of CDKS -phos of retinoblastoma protein leads to inc synth of CDKs |
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some other direct protein inhibitors of cdks? |
p27, p21, p16 |
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transcription factor that regs exp of genes and senses dna dmg. prevent cell cycle and promote apop |
p53 |
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p53 activites? |
p21, the inhibitor of cdks |
