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11 Cards in this Set
- Front
- Back
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What's our first big class of antiparasitic drugs?
Atovaquone ? |
Benzimidoles
Underlined: alternate drug to treating PCP pneumonia (P. Jeroveicci). Recall that normal treatment is bactrim (sulfamethoxasol and trimethoprim). Not underlined: mechanism - mess with mito ETC. rifampin decreases plasma concentrations. also, eat with fatty food. |
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Mebendazole?
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Underlined:
Good for our worms. Ascaris (roundworms) tricuris (whipworms) hookworms pinworms teratogenic in rats - so NO PREGGERS. non-underlined: inhibits microtublue synthesis. |
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Thiabendazole?
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underlined - lots of side effects. worse than other benzimidaoles or ivermectin.
so, it's contraindicated in pregnancy/hepatic/renal disease. alternative drug to ivermectin for strongyloidiasis! Also same alternative, to ivermectin, for cutaneous larva migrans. not underlined: inhibits microtubule formation |
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Albendazole?
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DOC drug for our worms:
underlined: choice for ASCARIS (roundworms), ENTEROBIASIS (pinworms), hookworms, cutaneous larva migrans, gnathostomiasis. still inhibiting microtubule formation. |
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Pyrantel pamoate?
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underlined - good for pinworms, ascaris, moderately effective against hookworms.
not underlined: this is a NEUROMUSCULAR blocker of helminths! release Ach, inhibit cholesterinase = paralysis. |
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Ivermectin?
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no pregnancy!
underlined: good for strongyloidiases and onchocercisis (river blindness) not underlined - works by paralysis, enhances GABA mediated signals. Careful with other drugs that up GABA (barbituates, benzos, valproate). |
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Diethylcarbamazine?
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underlined - for filiariasis, loiasis, and tropical eosinophelia.
only from CDC works by: immobilization of microfiliare, unknown. |
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Nifurtimox?
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for CHAGAS DISEASE.
american trypanosomiasis. |
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Suramin?
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Good for african trypanosomes (african sleeping sickness! Only from CDC.
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Pentamadine?
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Like Atovaquone, it's an alternative to PCP pneumonia, also an alternative to suranim for sleeping sickness.
SIGNIFICANT TOXICITIES. |
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Praziqantel?
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underlined - for schistosomes and cestode infections.
not underlined: opens their membranes to Ca++ = paralysis. |
