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5 Cards in this Set
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• Know the structure and physiology of Legionella spp.
• Know the environmental factors that are implicated in the spread of Legionella infections. How can these risks be eliminated or minimized. What is unique about the transmission of waterborne pathogenic Legionella pneumophila? • What are the major virulence factors of Legionella pneumophila? • Know how Legionella species are able to survive phagocytosis. • Know the main clinical diseases associated with Legionella spp. • What laboratory tests can be performed to confirm the diagnosis of Legionella infection? Although Legionella normally lives in water, it can only be cultured in the laboratory on a rich medium. What would be a possible explanation for this observation? |
objectives.
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morphology of legionella? where does it live?
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gram negative rod. it's a facultative intracellular organism - it can live in WBC's.
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how is legionella spread around?
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it's found in water sources, either manmade or natural. if aerosolized and inhaled it can infect. no person to person transmission.
note also that it can survive in amoebas and replicate there - it can also form a biofilm and hang out in water for long periods of time. |
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what diseases can legionella cause?
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pontiac fever - kinda like abrupt flu, lasting a week
legionella pneumonia - more serious, makes up to 10% of cases of hospital pneumonia. sometimes with diarrhea. |
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what are the major virulence factors of legionella?
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its ability to resist the phagolysosome, so it can live in WBC's and replicate.
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