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17 Cards in this Set
- Front
- Back
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In pancreatitis you see a significant elevation of the serum _____ and _____.
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Amylase
Lipase |
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What represents a reversible pancreatic parenchymal injury with associated inflammation?
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Acute pancreatitis
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What is the mild form of acute pancreatitis?
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Acute edematous pancreatitis
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What are the severe forms of acute pancreatitis?
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Acute hemorrhagic pancreatitis
Acute pancreatic necrosis |
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Enzyme activation in pancreatitis is due to injury to the _____ cell, _____ tract obstruction that allows backflow of bile and small intestinal contents into the pancreatic duct and/or pancreatic duct obstruction by _____ _____.
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acinar
biliary inspissated secretions |
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What is pancreatitis most common in?
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Alcoholism
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Gallstones are present in _____ of the pancreatitis patients.
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40-70%
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How many cases of pancreatitis may actually have a genetic basis?
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10-15%
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What is the ultimate result of pancreatitis?
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Enzymatic fat necrosis
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What are the enzymes that are activated in pancreatitis?
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Proteases
lipases amylases elastases |
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What is the morphology of pancreatitis?
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Hemorrhage and chalky white precipitates
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These tumors arise from exocrine ductal epithelium (only 1% from acinar cells), comprise approximately 90% of these malignancies, and are the fourth leading cause of cancer deaths in the U.S.
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Adenocarcinomas
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Adenocarcinomas can develop from both environmental ( _____) and genetic (_____) factors.
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cigarette smoking, fat rich diets, etc
mutations of p16 and p53 |
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What are the precursor lesions to adenocarcinomas called?
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Pancreatic intraepitheliar neoplasms (PanINs)
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What is the prevalence of adenocarcinomas in each part of the pancreas?
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60% Head
20% Body 10% Tail |
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Patients with adenocarcinomas may present with painless obstructive _____ due to impingement upon biliary tract structures.
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jaundice
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What is the five year survival rate for pancreatic carcinomas?
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5%
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