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8 Cards in this Set
- Front
- Back
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Systemic Mycoses
Primary Systemic Funguses |
-endemic to specific locations (e.g., China, India, etc)--- some prefer low pH environments, others prefer high pH environments; some prefer humid areas, others prefer dry areas
-exogenous sources (not part of normal flora) -can't be transmitted from person to person -dimorphic--- exist as mycelia at room temp and as yeasts inside the host -more prevalent in immunocompromised people (than in normal, healthy people) |
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Systemic Mycoses
Types of fungi that cause primary systemic mycoses (4) |
1) Cocidioidomycosis
2) Histoplasmosis 3) Blastomycosis 4) Paracocidioidomycosis |
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Systemic Mycoses
Histoplasmosis |
-fungi that cause primary systemic mycoses
-like all PRIMARY PATHOGENS, they enter the body via a primary complex and settle in the LUNGS, from where they can disseminate to the rest of the body -enter the lungs/alveoli as conidia (rather than as mycelia), b/c mycelia are too large to enter the alveoli and are phagocytoses |
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Systemic Mycoses
________ and _______ are variants of Histoplasma Capsulatum. |
-Var Capsulatum
-Var Debusie |
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Systemic Mycoses
Types of Histoplasmosis diseases (4) |
1) Acute pulmonary histoplasmosis
2) Chronic pulmonary histoplasmosis 3) Disseminated histoplasmosis 4) African histoplasmosis |
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Systemic Mycoses
Acute Pulmonary Histoplasmosis |
-occurs in immunocompromised patients (v. difficult to treat)
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Systemic Mycoses
_______ and acute pulmonary plasmosis are indestinguishable when viewed under a microscopic. |
-TB
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Systemic Mycoses
Histoplasmin |
-antibody secreted by histoplasmas during histoplasmosis (can be detected via serotological methods)
-similar appearance to TB antibodies (?) -histoplasmins that are produced in pt's who had histoplasma for several years are indestinguishable from TB antibodies -if pt is MALNOURISHED--> don't produce enough antibodies--> FALSE NEGATIVE results -serotological tests that are used include: 1) Complement Fixation-immunological test with RBC, 2) Immuno-Deficient serotological test |
