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20 Cards in this Set
- Front
- Back
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Benzodiazepine insomnia drugs (3)
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Flurazepam
Temazepam Triazolam |
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Flurazepam barnd name
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Dalmane
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Temazepam brand name
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Restoril
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Triazolam
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Halcion
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Temazepam/Restoril indication and PK
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insomnia
half life: 10-12h (long) Onset: 1 hr (long) CYP3A4 no active metabolites |
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Flurazepam/Dalmane
indication and PK |
insomnia
half life: 2h (80 for metabolite) Onset: 30 hr (fast) CYP3A4 1 active metabolites |
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Triazolam/Halcion
indication and PK |
insomnia
half life: 2-5 h (short) Onset: 15-30 min (Rapd)CYP3A4 |
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Flurazepam
Temazepam Triazolam preganancy cat and CS |
Category X
CS IV |
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Benzodiazepine receptor agonists
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Zolpidem (Ambien)
Zaleplon (Sonata) Eszopiclone (Lunesta) |
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Zolpidem (Ambien)
Zaleplon (Sonata) Eszopiclone (Lunesta) Pregnancy cat |
Cat C
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Zolpidem (Ambien) indication and PK
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insomnia
half life: 1-5hr Onset: 30 min CYP3A4 |
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Zaleplon (Sonata) indication and PK
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insomnia
half life: 1hr Onset: minutes (rapid) CYP3A4 |
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Eszopiclone (Lunesta) indication and PK
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insomnia
half life: 6 hr (longer) Onset: 30 min CYP3A4 |
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Properties of benzodiazepine agonists
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Bind same site as benzos
Bind alpha 1 site preferably Less risk of amnesia and tolerance vs benzos |
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Best drugs for rapid onset insomnia
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Zaleplon
Triazolam Zolpidem "Try getting Z Z's FAST and short" |
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Longest acting insomnia drug
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Temazepam
Escopicolone "It's Tempting to stay in bed a long time to Escape" |
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Slowest onset insomnia drug
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Temazepam
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Melatonin receptor agonist
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Ramelteon
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Remelteon pregnancy cat and CS
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Cat C
Not a CS |
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Remelteon indication and PK
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insomnia
half life: 1-3 hr (5) (midrange) Onset: 30 min CYP1A2 |
