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17 Cards in this Set
- Front
- Back
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Who gets Small-Cell Lung Cancer?
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Nearly always smokers.
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What are the most common presenting SXS of lung cancer?
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* Cough
* Weight loss * Dyspnea * Chest pain |
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What are the cancers grouped under "Non-Small Cell Lung Cancer?" (3)
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1) Adenocarcinoma
2) Squamous Cell Carcinoma 3) Large Cell Undifferentiated Carcinoma |
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How are lung cancers classified?
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By light microscopy.
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What cancer does SCLC resemble on light microscopy?
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Lymphoma.
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Where does SCLC like to metastasize?
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Endocrine organs.
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Aside from regional lymph nodes, were is the next most common site of metastasis for SCLC?
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The liver.
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How is SCLC staged?
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Staging:
* Limited = primary site + regional lymph nodes * Extensive = metastatic + pleural effusion |
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Lung Adenocarcinomas show histologic evidence of:
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* Gland formation
* Mucin production * Larger, more cohesive cells |
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Lung Squamous Cell Carcinoma show histologic evidence of:
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* Keratinization
* Keratin pearls or intracellular bridges |
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Large-Cell Differentiated Carcinoma appears histologically with:
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* Large amounts of cytoplasm
* Very large nuclei |
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What type of lung cancer is NOT classified by their line of differentiation?
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* Bronchioloalveolar Carcinoma (BAC) are defined by their growth patterns.
* BAC are uncommon, and account for <10% of lung adenocarcinomas |
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Squamous cell carcinomas tend to be located...
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...along or within major airways near the hilum.
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What is a "Paraneoplastic Syndrome?"
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Symptoms attributable to a humoral factor elaborated by a tumor.
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Name 3 Paraneoplastic syndromes ass'd. with lung cancer.
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1) Hypercalcemia: Squamous Cell Lung CA
2) PTH, ADH, ACTH: Small Cell Lung CA 3) Migratory Thrombophlebitis: Adenocarcinoma |
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How is SCLC treated? NSCLC?
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SCLC: Chemo and radiation
NSCLC: Surgery, sometimes radiation |
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What are two biological agents used in the treatment of lung cancer?
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1) Bevacizumab: VEGF antibody
2) Erlotinib: (TK inhibitor) |
