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26 Cards in this Set
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What the SXS of an Adult Infiltrative Neoplasm?
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1) First-time seizure
2) Unusual, persistent HA 3) Focal neurologic sxs, similar to stroke |
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__% of primary adult neoplasms are infiltrative.
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90% of primary adult neoplasms are infiltrative. Of these:
80% are Gliomas 10% are Primary Cerebral Lymphoma |
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What are gross characteristics of a Glioblastoma Multiforme (GBM)?
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Obvious mass with areas of necrosis and hemorrhage.
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What are micro characteristics of a Glioblastoma Multiforme (GBM)?
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Highly cellular with marked pleomorphism, necrosis and vascular cell proliferation.
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"Anaplastic" denotes what, in regards to infiltrative CNS tumors?
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Highly undifferentiated, malignant cell tumor. Large, hyperchromic nuclei, many mitoses, etc.
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What is the pathology?
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Astrocytoma
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What's the pathology?
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Glioblastoma multiforme (GBM)
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What is the pathognomonic micro appearance of an Oligodendroglioma?
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Small, compact nuclei with eosinophilic cytoplasm. "FRIED EGG" look.
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What patient class is at greatest risk for Primary Cerebral Lymphoma?
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Immunocompromised.
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What is the GROSS appearance of a Primary Cerebral Lymphoma?
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PCL often have multiple masses, typically located in deep gray matter or cerebral white matter.
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What is the MICRO appearance of a Primary Cerebral Lymphoma?
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High-grade, typically B-Cell Lymphoma
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What are the four infiltrative adult CNS tumors?
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1) Astrocytoma (regular or anaplastic)
2) Oligodendrocytoma (regular or anaplastic) 3) Glioblastoma Multiforme 4) Primary Cerebral Lymphoma |
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What are the three NON-infiltrative ADULT CNS tumors?
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1) Meningioma
2) Schwannoma 3) Secondary (distant mets) |
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What is the most common PEDIATRIC infiltrative CNS tumor?
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Medulloblastoma
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What are the two most common PEDIATRIC NON-infiltrative CNS tumors?
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1) Ependymoma
2) Pilocytic Astrocytoma |
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What are the MICRO features of a Meningioma?
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1) Whorls
2) Psammoma bodies (laminated calcific concretions) 3) Pseudo-nuclear inclusions |
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What's the pathology?
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Meningioma, fibrous variant.
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What's the most common location for a Schwannoma?
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Vestibular branch of the 8th Nerve.
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What's the most important ddx for a Schwannoma?
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Neurofibroma
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What are the three most common PRIMARY tumors which metastasize to the brain?
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1) Lung
2) Breast 3) Skin/Melanoma |
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What are the pediatric presenting SXS of an infratentorial tumor?
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1) Gait instability
2) Vomiting 3) HA |
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What are the three pediatric infratentorial tumors?
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1) Medulloblastoma
2) Ependymoma 3) Pilocytic Astrocytoma |
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What's the pathology?
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Medulloblastoma, showing Homer-Wright Rosettes
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What are the most common locations for a Pilocytic Astrocytoma?
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1) Posterior fossa (near foramen magnum)
2) Hypothalamic region & optic nerve |
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What's the pathology?
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Pilocytic Astrocytoma with Rosenthal Fibers
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