Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
14 Cards in this Set
- Front
- Back
|
What are the 7 common presenting signs and symptoms of renal cell carcinoma?
|
Weight Loss
Fever Anemia (chronic bleed) Hematuria Polycythemia (ectopic EPO) Flank Pain Abdominal Mass Hypercalcemia (ectopic PTH) |
|
|
How are renal neoplasms generally classified?
|
Renal neoplasias are on a spectrum, with adenoma (benign) to renal cell carcinoma (malignant).
|
|
|
von Hippel-Lindau Syndrome
|
Rare, autosomal dominant mutation of the VHL tumor suppressor gene.
|
|
|
What are the mortal components of the von Hippel-Lindau Syndrome?
|
* Renal Cell Carcinoma
* Cerebellar Hemangioblastoma * Pheochromocytoma |
|
|
What are the histologic characteristics of Renal Cell Carcinoma?
|
* Polygonal CLEAR CELLS (filled with either lipid or glycogen)
|
|
|
What are the treatments for Primary Renal Cell Carcinoma?
|
* Radical nephrectomy (cure possible w/out mets)
|
|
|
What are the treatments for Metastatic Renal Cell Carcinoma?
|
* IMMUNOTHERAPY
* Chemo and Radiation (limited success) * Resection of single metastases may prolong survival |
|
|
Name the Triad of Renal Cell Carcinoma.
|
1) Hematuria
2) Flank Pain 3) Abdominal Mass * present in only 10% of RCC pts |
|
|
What is the most common way Renal Cell Carcinomas are found?
|
Most RCCs are incidental findings on imaging studies.
|
|
|
What extra-renal complication is common in Renal Cell Carcinoma?
|
RCC frequently invades the renal veins or even the inferior vena cava
|
|
|
How does RCC commonly metastasize?
|
RCC frequently invades proximal veins, leading to early hematologic spread.
|
|
|
What is the most common risk factor associated with Renal Cell Carcinoma?
|
Smoking
|
|
|
Are clear cell cancers unique to the kidney?
|
No. Clear cell cancers may arise from the lung, gonad or kidney.
|
|
|
What are the 5 Renal Cell Carcinoma subtypes listed in the syllabus?
|
1) Oncocytoma
2) Clear Cell Carcinoma 3) Papillary Carcinoma 4) Chromophobe Carcinoma 5) Collecting Duct Carcinoma |
