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23 Cards in this Set
- Front
- Back
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highly motile
slender helical flagella |
treponema (spirochete)
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what is responsible for most clinical manifestations in non-venereal treponematoses?
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host immune responses
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yaws
pinta Bejel (endemic) what class of conditions are these? |
non-venereal treponematoses?
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at increased risk of what due to its genital ulcers?
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HIV
syphilis |
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penetrate abraded skin or mucus membranes
what happens after inoculation? |
systemic dissemination
syphilis |
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syphilis
primary stage |
chancre
- indurated, painless ulcer |
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rash
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secondary stage of syphilis
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benign gummas
aortic aneurysms (CV) neurosymptoms |
tertiary stage of syphilis
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syphilis
which individuals are infectious? |
those with early latency
late latency & tertiary usually NOT infectious |
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syphilis
principle proinflammatory mediators |
treponema membrane lipoproteins
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HIV pt
response to syphilis infection? |
strong antibody response (in all infected individuals)
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what type of pathogen is treponema? what can it do? how?
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stealth pathogen
can survive despite high titers of Ab - doesn't display its major immunogens on outer surface = not accessible to cidal Ab |
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stealth pathogen
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treponema/syphilis
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no protective immunity
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syphilis
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what does a reactive treponemal test denote?
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present or past infection
- remain reactive for life |
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syphilis
tx? alternative? contraindication for alternative? |
penicillin
- tetracycline for early - except children <8 (stunt growth) |
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neurosyphilis
tx? |
high dose, parenteral penicillin
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several hours after treatment w/ penicillin
sudden fever flushing tachycardia vasomotor instability - life-threatening |
Jarisch-Herxheimer reaction
- from therapy for primary and secondary dz |
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Syphilis
pt has a penicillin allergy tx? |
de-sensitize them
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Third World problem
sores on skin, bones, cartilage NEVER attacks CNS pathogen? |
subspecies T. pertenue
Yaws (Frambesia) |
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painless papillomas
tx? |
penicillin/tetracycline
early yaws |
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lesions confined to skin
T. carateum |
Pinta
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periodontal disease
polymicrobial flora of gingival disease |
T. denticola
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