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17 Cards in this Set

  • Front
  • Back
Inheritance patterns
All heritable cancer syndromes are autosomal DOMINANT unless otherwise specified
Retinoblastoma
Retinoblastoma
Osteogenic sarcoma
MEN I
Parathyroid
Pituitary
Pancreas
MEN IIa
Medullary thyroid
Pheochromocytoma
Parathyroid
MEN IIb
Medullary thyroid
Pheochromocytoma
Mucosal neuroma
Familial adenomatous polyposis (FAP)
APC tumor suppressor mutation
Hundreds of colon polyps
Inevitably cancerous (colectomy by age 25)
Gardner's syndrome
FAP
BONE tumors
Soft tissue tumors
Turcot's syndrome
FAP
CNS tumors
HNPCC
(Lynch syndrome)
DNA mismatch repair defect
Endometrial, Ovarian (think krukenberg)
GI (any level)
Hepatobiliary
Urinary tract
Brain
Skin
Peutz-Jegher's syndrome
Perioral FRECKLES
GI POLYPS (noncancerous)
Non-colon cancer (stomach, breast, ovaries)
Colon cancer risk is NOT INCREASED
NF-1
Neurofibromas (Schwann/fibroblast/mast cell tumor)
Cafe-au-lait spots
Optic gliomas, Lisch nodules (little brown hamartoma)
PHEOchromocytoma
WILMS tumor
Leukemia
Macrocephaly
Long bone cortical thinning
NF-2
(nonsense mutation, usually)
Bilateral ACOUSTIC NEUROMAS
Meningiomas
CATARACTS
Tuberous sclerosis
Infantile SPASMS
ANGIOFIBROMA (red papules on face that persist)
MR
Glial nodules
RENAL angiomyolipomas
CARDIAC rhabdomyomas
Von Hippel-Lindau
CEREBELLAR hemangioblastomas
RENAL cell carcinoma
Liver/kidney CYSTS
Xeroderma pigmentosa
Autosomal RECESSIVE
Defect in UV DNA damage repair
Easy SUNBURN, freckling
Photophobia
Skin cancer risk
Albinism
Autosomal RECESSIVE
Melanin production defect
Photophobia, NYSTAGMUS, astigmatism
Skin cancer risk
Beckwith-Wiedemann (BWS)
HYPOGLYCEMIA
Macroglossia, macrosomia
Midline abdominal defects
Ear malformations
Cancer (Wilm's, hepatoblastoma, etc)
No increased risk of adult cancer