Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
17 Cards in this Set
- Front
- Back
|
Action at the synapse |
1) AP arrives at terminal 2) membrane depols 3) Ca enters the N terminal 4) vesicles bind to membrane 5) NT diffuses across 6) shape of membrane changes |
|
|
Facilitation |
-neurons act on presynaptic membrane to cause depol and release more NT |
|
|
Inhibition |
neurons act on presynaptic membrane to causes hyperpol and release less NT |
|
|
Acetylcholine |
-sleep/wake cycle, MM activation, used in ParaNS - either bind to muscarinic or nicitinic R M - in the cortex, midbrain and are ParaNS N - at the NMJ |
|
|
GABA |
-amino acid NT -inhibitory NT in the basal ganglia |
|
|
Glutamate |
-amino acid NT -excitatory NT in the thalamus and cortex |
|
|
Glycine |
-amino acid NT -inhibitory NT that acts on interneurons in the SC and brainstem |
|
|
Dopamine |
-amine NT -excites or inhibits -implicated in parkinsons and schizophrenia |
|
|
Epinephrine |
-amine NT -doesn't do a lot in the brain |
|
|
Norepinephrine |
-amine NT -excites or inhibits in the sleep/wake cycle |
|
|
Serotonin |
-amine NT -released by raphe nuclei -mostly inhibits -controls mood, sleep, arousal, and is implicated in depression |
|
|
Endorphins |
-neuroactive peptide NT -analgesic in PNS and CNS |
|
|
Enkephalins |
-neuroactive peptide NT -suppresses pain as it comes in the dorsal horn |
|
|
Substance P |
-excitatory neuroactive peptide NT -causes you to feel pain |
|
|
Myesthenia Gravis |
-chronic autoimmune disorders -body makes antibodies against nicotinic receptors at the NMJ |
|
|
Signs of Myesthenia Gravis |
-patient gets progressively weaker with repeat contractions -often affects MM innervated by cranial NN -trouble with eye tracking, and swallowing |
|
|
What drugs treat myesthenia gravis? |
-drugs that block acetylcholinesterase |
