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37 Cards in this Set
- Front
- Back
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"acute" pre-chemo emesis occurs ______ , and is ___________ mediated
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<24h
serotonin |
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"delayed" emesis onset occurs _________, and is __________ mediated
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>24h
dopamine |
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what are the risk factors for emesis in a chemo patient?
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Female
younger age no prior chemo |
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a patient with a social Hx of smoking will have an increased risk of emesis. true or false?
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false
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a patient with a social Hx of alcohol abuse will have an increased risk of emesis. true or false?
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false
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a patient with a social Hx of alcohol abuse will have a decreased risk of emesis. true or false?
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true
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a patient with a social Hx of smoking will have a decreased risk of emesis. true or false?
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false
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MOA of Zofran?
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inhibits 5-serotonin
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generic name for Zofran?
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ondansetron
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brand name for ondansetron?
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Zofran
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dosage forms of Zofran?
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PO
IV |
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which of the following are true regarding ondansetron except?
a. risk of QTc prolongation b. Dopamine antagonist c. 5-serotonin antagonist d. available as PO and IV e. given 30min prior to chemo |
dopamine antagonist
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ondansetron is a QTc prolonging drug. true or false?
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true
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generic name for Aloxi?
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palonosetron
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dosage forms for palonosetron?
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IV only
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dose and route of admin for palonosetron?
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0.25mg IV
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dose and route of admin for ondansetron?
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16mg IV
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which of the following have the longest t1/2?
a. ondansetron b. granisetron c. dolasetron d. palonosetron |
palonosetron
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name the class of drugs used for the prevention of acute emesis?
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5-serotonin antagonists
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5-serotonin antagonists are used for the _________ (Tx/prevention) of _________ (acute/chronic) emesis.
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prevention
acute |
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dose and route of admin of Aprepitant?
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125 mg PO
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dose and route of admin of fosaprepitant (Emend)?
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115 mg IV
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brand name of fosaprepitant?
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Emend
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dose and route of admin of Emend?
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115 mg IV
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max dose of dexamethasone when used concomitantly with aprepitant?
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10 mg
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dose and route of admin of dexamethasone?
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8-20 mg
PO or IV |
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all the 5-HT3 antagonists are equivalent. true or false?
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true
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PO 5-HT3 antagonists are just as effective as IV. true or false?
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true
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PO 5-HT3 antagonists are not as effective as IV. true or false?
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false
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Emend is typically used for _______ days.
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3
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corticosteroids will increase the efficacy of 5-HT3 antagonists by _______%
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20
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Emend is typically a _______ day regimen. _________mg on day _______, and _________mg on day _______
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3 day
125 80 2 and 3 |
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what drugs are in anti-emotogenic "triple therapy"?
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Zofran 24mg PO
aprepitant 125mg PO dexamethasone 10 mg PO |
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Emend IV should not be used for "emesis rescue". true or false
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true
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aprepitant should always be used for emesis "rescue". true or false
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false
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which of the following can be used as emesis "rescue" meds?
a. zofran b. Emend c. metoclopramide d. dexamethasone e. aprepitant |
metoclopramide
dexamethasone |
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typical drugs used for delayed emesis?
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dexamethasone
metoclopramide prochloroperazine |
