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116 Cards in this Set

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What are four reasons for low farrowing rates?
1. Low conception rates: 21 d return
2. Low conception rates: irregular return
3. Non infectious abortion
4. Pseudopregnancy
List five noninfectious factors for low farrowing
Parity
Season
Environment
Genetics
Breeding management
When (during pregnancy) do you have primary maternal recognition of pregnancy?
What about mineralization?
1. 10-15d
2. 35-40d
Name some reasons for conception failure
Name some reasons for pregnancy failure
Conception failure: management, mycotoxins, reproductive disease, boar/semen, temperatures, farrow to service interval, parity

Pregnancy failure: systemic disease, environment/facilities
How do you manage low farrowing rates?
Improve estrus detection techniques
Improve breeding program* (careful)
Overbreed
Blame infectious agents
Case: Sows are experiencing high fever and rhinitis. In addition, there has been an increase in abortions and mummies. Of the piglets that are born, most are weak and a few have CNS signs. Some of your finishers have resiratory signs
Pseudorabies (PRV)
Necropsy: Viral pneumonia and encephalitis , Focal necrosis of lung/liver/tonsil/brain , Placentitis, Fetal infection
Pseudorabies
How do you diagnose pseudorabies?
Serology (Ab)
VI (tonsil or lung)
Fab (tonsil or brain)
Histopath (brain)
How do you treat pseudorabies?
NONE for neonates
Infected herds: quarantine/depopulate
What can you do to control an outbreak of pseudorabies?
Gene-deleted vaccine
How is pseudorabies transmitted?
Pig-pig!
Also: fomites, dogs

Not in semen
What can you get from urine contaminated water from feral animals/rodents
Lepto interrogans (pomona is the big one)
Case: Sows give birth to weak-born piglets. They have a distinctive high-pitched squeal. On necropsy, there are NO lesions in the majority of the pigs, but a few have mottled kidneys.
Lepto
What samples do you submit to Iowa State for Lepto check? How do they check?
1. Aborted fetus and placenta
2. Isolation, darkfield microscopy, Fab
3. Paired serology with increase 4x titers
What do you do when you suspect Lepto in your herd?
Revaccinate the herd while waiting for diagnostic results
How do you prevent Lepto?
1. Secure feed and water sources
2. Control rodents/wildlife
3. Vaccinate breeding stock before each breeding (MC vaccine = 6-way Lepto + PPV + Erisypelas
This is an acute and highly infectious single strand RNA viral disease of pigs. It has 15 hemagglitinin and 9 neuaminidase glycoprotein spikes
Swine Influenza
Case: You have a group of pigs. The temperature got really low a few days ago and chilled the pigs. Now they have a cough that is deep and productive. They are all very depressed and have high temperatures
Swine Influenza
Why do we worry about Swine Influenza?
Antigenic drift from pig to human (also worry about human to pig in industry)
What is the primary way to diagnose Swine Influenza?
Fresh and formalized tissue samples: Immunohistochemistry*preferred
Virus Isolation from nasal swabs and sequencing (expensive)

Note: can swab live or post acute pigs
Necropsy: You notice a tropism for the bronchial epithelium. There is cranioventral to pathy diffuse pneumonia, interlobular edema, and fibrinous exudate in bronchi. A few pigs had gastric ulcers.
Swine Influenza
How do you control Swine Influenza?
VERY HARD
Extensive monitoring (nasal swabs-typed)
Continuously updated autogenous vaccine –but 90d USDA approval (commercial just won’t cover all strains)
BIOSECURITY DOES NOT WORK
High compliance human vaccination
Breeding herd vacc-b/c high fever can lead to abortions
What are two potential problems why a swine influenza vaccine would not work
Maternal Ab interference from vaccinating too early

Vaccinating for the wrong strain
What is the causative agent of necrotizing pleuropneumonia in pigs
Actinobacillus pleuropneumoniae (APP)
True/False: APP serologic tests are effective in diagnosing
FALSE-unreliable and misleading
What are the two types of toxins produced by APP?
LPS: Endotoxin (Lipopolysaccharide)
RTX: Exotoxin (Cytotoxin)
True/False: With APP, carriers are common after recovery
True
What serotypes of APP are most virulent?
1 & 5
Case: Pigs with rapid onset, acute death. Some CS of pigs were cyanoisis, mouth breathing, gasping and blood tinged froth from nostrils. On necropsy, there is extensive fibrinous pleuritis (adhered to ribcage in some cases) and some abscessation of the lungs
APP
What is the ideal diagnostic technique for APP
Culture ID
How could you save a pig herd with APP?
Water medicate-tetracyclines (broad) Inject ceftiofur in clinically affected (or all bigs in that pen or barn) and walk through 2x/day b/c disease progresses so quickly

OTHERWISE: Depopulate when highly virulent and reopulate breeding herd with negative animals
You were convinced you had APP. However, you noticed some skin lesions that appear similar to erisipelas like lesions. What might you have?
Actinobacillus suis
Necropsy: You have lung abcesses. List several differentials.
PRRS
APP
Salmonella
Mycoplasma
Influenza
PRDC (porcine respiratory disease complex)
This is a zoonotic disease that causes abortion at ANY time during gestations? Pigs will also have poor conception rates after abortion or irregular returns.
Brucella suis
Factors affecting irregular return to estrus (26-37d post mating)
Parity
Season
Infectious agents (parvo, PRRS)
Mycotoxins (zearalenone)
Factors affecting 21d return to estrus
Parity
Season
Boar Use
Environment/Housing
Heat detection/breeding procedure
How can you correct low conceptions rates due to 21d return to estrus
Improve breeding procedures
Optimize boar exposure for estrus detection
# matings/estrus
How can you correct low conception rates due to irregular return to estrus
Records
Ultrasound pregnancy testing
Abattoir exam
Typical duration of estrus for a sow?
For a gilt?
Sow: 36-72hrs
Gilts: 36hrs
Two infectious agents that can cause irregular return to estrus
Parvovirus, PRRS
What can cause an artificially low farrowing rate
Culling of animals due to lameness, etc
What is the noninfectious cause of abortion?
Autumn Abortion Syndrome
What noninfecitous cause of abortion shows no CS in the sow and can occur at any stage of gestation.
Autumn Abortion Syndrome
What is the etiology of Autumn Abortion Syndrome
Environmental temperature fluctuations and Marginal energy balance
What do you call a full length "pregnacy" that fails to farrow at the end?
Not-In-Pig Sow
About when does a pig return to estrus for a pseudopregancy
about 50d
When are the embryos resorbed in psuedopregnancy?
After MRP (10-15d) but before minerlization
What are some Ddx for pseudopregnancy?
Parvovirus
Heat stress at implantation
Regrouping sows after breeding
Zealalenone toxicity
What causes uterine edema and "purple glycoprotien" endometrial secretions?
Zearalenone toxicity
When are psuedopregnancy and NIP most common?
Nov-Jan (after summer matings)
Two reproductive viruses that will show signs in sow normally
PRRS and pseudorabies
How can you correct psudopregnancy and NIP
Slaughterhouse exam to confirm
Feed analysis for mycotoxins
Assess animal flow and stressors
PG injections (CAREFUL!)
#1 virus pathogen in US in pigs
PRRS
Samples to take for PRRS
Tonsil, lung, serum
Primary transmission for PRRS
Pig-Pig = #1
Also mechanical (blood), aerosol, fomites, shed in semen
Name three factors influencing stillbrith rates
Parity
Litter size
Room temperature
Gestation length
Farrowing process
Piglet Size
Sow Condition
Noxious gasses
When are normal vaginal discharges expected in a sow? How about a prepubescent gilt?
Sow: estrus, service/mating, post farrowing, urine

Prepubescent gilt: NO normal discharge
What are abnormal discharges or urogenital infections in sows
Endometritis/metritis
Vaginitis
Blood
Cystitis/pyelonephritis
Crystalluria
Urolithiasis
What repro disease causes no CS in the sow?
Parvovirus

rare CS in sows with Lepto
What predisposes to post-breeding discharge?
Forced 3rd mating late in estrus
What disease is biosecurity not helpful
Swine Influenza
What disease do you have if you have piglets with high-pitched squealing and curled up toes?
Lepto
What would be a cause for "virgin" gilt discharges
dorsal-ventral bands in cervical os "persistent hymen"
What do you do with a pig that has post-breeding discharge
CULL
What is the pathogenesis of UTIs
bacteria-->ascending infection
Which disease has a vaccine that helped eradicate it?
Pseudorabies-gene deleted vaccine was excellent control in outbreaks (could differentiate infected from vaccinated)
#1 tissue to sample for a pseudorabies virus
palantine tonsils
When do you wean pigs
about 8 weeks
What kind of virus is psuedorabies
Herpesvirus
What is the normal USG in a sow
1.010
Producer calls and says he had a sow that just aborted and he asks you for advice on what to do with her-what do you say?
Don't want to breed on 1st estrus..breed her on estrus after that

No breeding on 1st estrus after abortion
Which disease has umbilical cord vasculitis that is larger than your finger?
PRRS
Guy has a herd that is a PRRS free herd but they are worried about it. Should they vaccinate?
NO-do not vaccinate because the vaccine is MLV...it modifies itself later and then becomes live
Which disease historically causes ears to turn blue
PRRS
What should you do if you get a diagnosis of Pseudorabies
REPORT IT
What type of water delivery system is more likely to cause UTIs
common water trough
What can cause a reoccurence of infectious reproductive disease?
Introduce naive animals
herd loses immunity
Overwhelming re-exposure
Normal respiratory rate of pig
15-20
What are the two major serotypes in PRRS
US and Lelystad
Two diseases that cause blue ears
Salmonella and PRRS
Want to know if you have Mycoplasma hypopneumoniae. How do you tell?
History, CS and gross lesions are very typical

To test prevalence in a commercial farm: ELISA unless vaccinated
Diagnositics for Swine Influenza
Formalized and fresh tissue sample for immunohistochemisty

Nasal swabs
Two reasons for vaccination failure of Swine Influenza
Maternal ab interference

Vaccinated with wrong strain
What is the best way to get rid of APP?
Depopulate
In what disease do you not want to cross-foster your piglets
PRRS because pigs are born viremic
In piglets with PRRS, what is the attributing factor for CS?
Secondary infections
What causes late term abortions?
PRRS
Lepto (mid-late)
What causes abortions at any stage of gestation?
Pseudorabies
Brucella
With what disease will you see stillbirths after abortions and before mummies?
PRRS
Disease that DOESN'T cause abortions
Parvovirus
What disease causes stillborns with abortions and after (no elevation in mummies)
Lepto
You have mummies that are all approximatley the same size in litters. What disease might this be?
PRRS
You have mummies that are many different sizes within a litter. What disease might you have?
Parvovirus
You have early abortions due to irregular returns. These same animals cycle but fail to conceive. What disease might cause this?
Brucella
You have irregular returns primarily in your gilt population. On subsequent matings, they are fertile. What disease might you have had?
Parvovirus (PPV)
I say SMEDI, you say...
Parvovirus (PPV)
Acute/Atypical PRRS =
Sow Abortion and Mortality Syndrome
What is the gold standard for PRRS diagnosis
Immunohistochemistry on lung tissue
True/False: There are NO current methods to minimize fetal losses once an outbreak of PRRS begins
True

Control beforehand: preweaning mortality through piglet management
*stop cross fostering, euthanize sick, all-in-all-out
How would you test a mummy that was less than 70d for PPV?
Test for ANTIGEN by FA of lung

Fetus is not immunocompetent
How would you test a mummy that was older than 70d or was stillborn for PPV?
ANTIBODY in serum, CSF, or thoracic fluid

fetus is immunocompetent at this point
How do you prevent PPV?
MLV vaccine

Gilts 2x prior to mating
Sows 2x/yr
What disease causes infection to the fetus ONLY
PPV
What are agents in PRDC (Porcine Respiratory Disease Complex)
Mycoplasma pneumonia, Swine Influenza, PRRS

also: PCV-2, P.multocida, A. suis, other bacteria, gastric ulcers
Case: You have some pigs with a dry, hacking, nonproductive cough that began 6-8wks after placement in a finisher barn and persisted for a few weeks. Morbidity is high. Necropsy showed firm/rubbery lungs in cranioventral lobes.
Mycoplasma hypopneumoniae
How is Mycoplasma hypopneumoniae perpetuated in production?
Gilts perpetuate by shedding it in birth secretions-->piglets get infected (maternal ab protects initially)
How soon can you use the Mycoplasma vaccine? Does it work?
Effective if it is properly timed: Give at weaning + booster 2 weeks later

Use as young as 7d = no interference with maternal Ab
What is a costly ubiquitous endemic disease of growing pigs?
Mycoplasma hypopneumoniae
What disease affects finishing pigs (14-15wks) in the US and causes depression, failure to grow/thrive, wasting, wt. loss, stupor. On necropsy you see granulomatous lymphadenitis, lymphoid depletion, and histiocytic lymphadenopathy?
Porcine circovirus type 2 associated disease (PCVAD)
How can you control Porcine circovirus type 2 associated disease?
Vaccinate nursery pigs about 3 weeks (@weaning)
Case: You have a group of pigs that suddenly have a deep, productive cough. Necropsy shows a cranioventral to patch/diffuse pneumonia, interlobular edema, and fibrinous bronchitis.
Swine Influenza
What is a costly disease at slaughter that causes caseous lymphadenitis
TB-Mycobacterium avium
What is a normal colonizer of the upper respiratory tract that can get out of hand and cause sneezing, inclusion body rhinitis, and "whooping cough" of nursery pigs
Bordetella bronchiseptica
Disease that causes necrotizing pneumonia, acute death, cyanosis (blue ear), and thumping
Salmonella choleraesuis
What highly contagious, host-specific disease has a tropism for respiratory epithelial cells, but is not currently a significant pathogen
Porcine Respiratory Coronavirus (PRCV)
What might cause a productive asthmatic cough (wheeze-thump) due to hepatotracheal migration and may cause liver and lung damage + inflammation
Ascaris suum (large roundworm)