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75 Cards in this Set
- Front
- Back
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Class of Fluoxetine
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SSRI
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Class of sertraline
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SSRI
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Class of Paroxetine
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SSRI
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Class of Citalopram
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SSRI
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Class of Escitalopram
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SSRI
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MOA of SSRIs
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Blockade of presynaptic serotonin reuptake to increase synaptic free serotonin concentration and postynaptic serotonin receptor occupancy
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Indications for SSRIs
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First-line therapy for depression, anxiety
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Class of Venlafaxine
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SNRIs
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Class of duloxetine
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SNRIs
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MOA of SNRIs
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inhibit reuptake of both serotonin and norepinephrine in a similar fashion to TCAs
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Indications for SNRIs
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First line for treatment of depression with comorbid neuropathic pain
Second line for depression failing SSRI therapy |
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Major class side effects of SSRIs
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Sexual dysfunction
Require 3-4 weeks for full efficacy May increase risk of suicidal ideation in adolescents Serotonin Syndrome |
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Major class side effects of SNRIs
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Hypertension
Nausea, dizziness, insomnia, sedation |
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Class of imipramine
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TCA
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Class of amitriptyline
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TCA
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Class of Desipramine
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TCA
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Class of nortriptyline
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TCA
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MOA of TCAs
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Blockade of norepinephrine and serotonin reuptake to potentiate postsynaptic receptor activity
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Indications for TCAs
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Second-line for treatment of depression
Useful in patients with comorbid neuropathic pain |
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Major class side effects of TCAs
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Cardiotoxicity - QTc prolongation
Sexual dysfunction Sedation Anticholinergic symptoms Lethal in overdose |
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Class of Phenelzine
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MAOI
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Class of isocarboxazid
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MAOI
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Class of tranylcopromine
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MAOI
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Class of selegiline
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MAOI
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MOA of MAOI
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Blockade of monoamine oxidase activity to inhibit deamination of serotonin, norepinephrine and dopamine
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Indications for MAOIs
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Third-line for depression
Useful for treatment of depression with neurologic symptoms, or refractory cases |
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MOA of bupropion
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Inhibition of dopamine and norepinephrine reuptake
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Indications for duproprion
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Depression with fatigue, difficulty concentrating, or comorbid ADHD
Smoking cessation |
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Major class side effects of MAOIs
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Dizziness, dry mouth, fatigue
Consumption of foods containing tyramine can cause hypertensive crisis |
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Major side effects of buproprion
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Insomnia, weight loss
NO sexual side effects |
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MOA of Trazodone
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Unknown; related to serotonin activity
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Indications for trazodone
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depression with significant insomnia
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Major side effects of trazodone
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Sedation, hypotension, nausea
Priapism Seizure risk at high doses |
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Class of mirtazapine
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Tetracyclic antidepressant
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MOA of mirtazapine
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blockade of alpha-2 adrenergic receptors and serotonin receptors to increase adrenergic neurotransmission
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Indications of mitrazapine
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Depression with insomnia
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Major side effects of mirtazapine
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Dry mouth, weight gain, sedation
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Class of alprazolam
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Benzodiazepine (short acting)
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Class of clonazepam
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Benzodiazepine (Long-acting)
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Class of diazepam
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Benzodiazepine (Long acting)
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Class of lorzaepam
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Benzodiazepine (Intermediate acting)
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MOA of Benzodiazepines
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Increase GABA inhibition of neuronal firing
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Indications for benzodiazepines
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Anxiolytic for panic attacks
Shrot-term treatment of insomnia Prevention of alcohol withdrawal |
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Adverse effects of Benzodiazepines
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sedation, confusion, Addition potential with withdrawal syndromes
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MOA of buspirone
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Unknown, but related to serotonin and dopamine receptors
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Indication for buspirone
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Anxiety disorders in which abuse or sedation is a concern
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Side effects of buspirone
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Headaches, dizziness, nausea
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What is the antidote for benzodiazepine overdose?
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Flumazenil
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Class of Clozapine
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Atypical Antipsychotic
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Class of risperidone
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Atypical Antipsychotic
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Class of olanzapine
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Atypical Antipsychotic
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Class of sertindole
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Atypical Antipsychotic
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Class of quetiapine
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Atypical Antipsychotic
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Class of ziprasidone
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Atypical Antipsychotic
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Class of paliperidone
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Atypical Antipsychotic
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Class of ariipiprazole
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Atypical Antipsychotic
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MOA of Atypical Antipsychotics
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Blockade of dopamine and serotonin receptors
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Indications for Atypical Antipsychotics
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First-line drugs for maintenance therapy for psychotic disorders
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Major class side effects of Atypical Antipsychotics
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Anticholinergic effects
Weight gain Seizures Arrhythmias Agranulocytosis |
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Which atypical antipsychotic is the worst offender for metabolic issues?
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Olanzapine
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Which atypical antipsychotic is the worst offender for agranulocytosis?
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Clozapine
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Class of Haloperidol
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High-potency Typical antipsychotics
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Class of droperidol
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High-potency Typical antipsychotics
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Class of fluphenazine
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High-potency Typical antipsychotics
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Class of loxapine
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High-potency Typical antipsychotics
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Class of thiothixene
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High-potency Typical antipsychotics
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Class of perphenazine
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High-potency Typical antipsychotics
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Class of trifluoperazine
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High-potency Typical antipsychotics
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MOA of Typical antipsychotics
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Blockade of D2 receptors
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Indications for high-potentcy typical antipsychotics
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Strong positive symptoms
Emergency control of agitation or psychosis Second-line for maintenance therapy |
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Major class side effects of High-potency Typical antipsychotics
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Extrapyramidal symptoms (Dystonia, parkinsonism, akinesia, akathisia)
Tardive dyskinesia Sexual dysfunction Neuroleptic malignant syndrome |
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Class of thioridazine
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Low-potency typical antipsychotic
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Class of chlorpromazine
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Low-potency typical antipsychotic
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Indications for low-potency typical antipsychotics
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Strong positive symptoms
Second line for maintenance therapy |
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Major class side effects of low-potency typical antipsychotics
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Fewer extrapyramidal side effects
Anticholinergic effects |
