Sus2 - Neurologic Disorders: Pharmacology

Front 1

MOA of Carbamazepine

Back 1

Inhibition of voltage-dependent sodium channels

Front 2

MOA of Phenytoin

Back 2

Inhibition of voltage-dependent sodium channels

Front 3

MOA of Lamotrigine

Back 3

Inhibition of voltage-dependent sodium channels

Front 4

MOA of Oxcarbazepine

Back 4

Inhibition of voltage-dependent sodium channels

Front 5

MOA of Zonisamide

Back 5

Inhibition of voltage-dependent sodium channels

Front 6

MOA of Ethosuxamide

Back 6

Inhibition of neuronal calcium channels

Front 7

MOA of phenobarbital

Back 7

Enhanced GABA activity

Front 8

MOA of pentobarbital

Back 8

Enhanced GABA activity

Front 9

MOA of benzodiazepine

Back 9

Enhanced GABA activity

Front 10

MOA of Tiagabine

Back 10

Enhanced GABA activity

Front 11

MOA of valproate

Back 11

inhibition of sodium channels and enhanced GABA activity

Front 12

MOA of Topirimate

Back 12

Inhibition of NMDA-glutamate receptors and enhanced GABA activity

Front 13

Typical anti-seizure use of carbamazepine

Back 13

Monotherapy for partial or generalized convulsive seizures

Front 14

Typical anti-seizure use of phenytoin

Back 14

monotherapy for partial or generalized convulsive seizures, status epilepticus

Front 15

Typical anti-seizure use of Lamotrigine

Back 15

Partial seuzres
Second-line for generalized convulsive seizures

Front 16

Typical anti-seizure use of Oxcarbazepine

Back 16

Monotherapy for partial or generalized convulsive seizures

Front 17

Typical anti-seizure use of Zonisamide

Back 17

Second line for partial and generalized convulsive seizures

Front 18

Typical anti-seizure use of ethosuxamide

Back 18

Absence seizures

Front 19

Typical anti-seizure use of barbiturates

Back 19

Nonresponsive status epilepticus

Front 20

Typical anti-seizure use ofBenzodiazepine

Back 20

Status epilepticus

Front 21

Typical anti-seizure use of Tiagabine

Back 21

Second line drug for partial seizures

Front 22

Typical anti-seizure use of Valproate

Back 22

Monotherapy or second drug for partial and generalized seuzires

Front 23

Typical anti-seizure use of topiramate

Back 23

Second-line drug for partial and generalized seizures

Front 24

Typical anti-seizure use of gabapentin

Back 24

Monotherapy or second drug for partial seizure

Front 25

Typical anti-seizure use of levatiracetam

Back 25

monotherapy for partial seizres
Second-line drug for partial or generalized seuizres

Front 26

What is the treatment of choice for tension headaches?

Back 26

NSAIDs

Front 27

What is the treatment of choice for Cluster headaches?

Back 27

100% O2 (6+ L/min on nonrebreather) for 20+ minutes
Sumatriptan or dihydroergotamine

Front 28

What is the treatment of choice for migraine headaches?

Back 28

Sumatriptant, dihydroergotamine, NSAIDs, and/or antiemetics (though vasoconstrictors shouldn't be mixed)

Front 29

MOA of Levodopa

Back 29

Dopamine precursor

Front 30

MOA of Carbidopa

Back 30

Dopamine decarboxylase inhibitor - reduces rlevodopa metabolism

Front 31

MOA of bromocriptine

Back 31

Dopamine receptor agonist

Front 32

MOA of Selegiline

Back 32

MAO-B Inhibitor

Front 33

MOA of Amantadine

Back 33

Increases synthesis, release or reuptake of dopamine

Front 34

MOA of benztropine

Back 34

Blockade of cholinergic transmission

Front 35

Indications for levodopa

Back 35

Initial therapy for Parkinson's Disease

Front 36

Indications for carbidopa

Back 36

Parkinson's Disease - Combination therapy with levodopa

Front 37

Indications for bromocriptine

Back 37

Parkinson's Disease - increases response to levodopa in patient's with a declining response

Front 38

Indications for Selegiline in Parkinson's disease

Back 38

Used in early disease - may help delay need to start levodopa

Front 39

Indications for Amantadine in Parkinson's disease

Back 39

Used to treat rigidity and bradykinesia

Front 40

Use of Valerian

Back 40

OTC herbal used for Insomnia
Studies show no benefit

Front 41

Which patient populations should avoid the use of antihistamines for insomnia? Why?

Back 41

Antihistamines
Anticholinergic side effects can be detrimental in the elderly (orthostasis, delirium) and can exacerbate dementia

Front 42

What is a common medication of choice in elderly patients with insomnia?

Back 42

Trazodone

Front 43

What is a common medication of choice for treatment of insomnia is depressed patients during the early phase of treatment (before antidepressant effect is realized)?

Back 43

Benzodiazepines

Front 44

What is the one medication that may slow progression of ALS?

Back 44

Riluzole

Front 45

MOA of Riluzole

Back 45

Decreases glutamate-induced excitotoxicity