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14 Cards in this Set
- Front
- Back
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What are the two important sulfonamides? What is their mech. of action?
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Sulfadimethoxine
Sulfamethazine |
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What is Sulfa drugs mechanism of action?
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Inhibits folic acid synthesis
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Are sulfonamides time or concentration dependent?
Are the Bacteriostatic or Bactericidal? What bacteria do they work against? |
Time
Static G+ a/a, G- a/a (broad spectrum) |
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Do potentiated sulfonamides cross the BBB?
What other drug is effective against toxoplasmosis? |
Yes
Clindamycin (Linco) |
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What are four adverse effects of sulfonamides?
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1) Renal damage due to crystals
2) Dry eye 3) Hypersensitivity 4) Antagonize Vit K |
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What are the three Diaminoprymidines
?
What is the mechanism of action? |
Trimethoprim (TMP)
Ormetoprim Pyrimethamine Blocks the conversion of folic acid to tetrahydrofolic acid |
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Are Diaminopyrimidines
time or concentration dependent? Bacterioidal or Bacteriostatic?
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Time
Static |
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What bacteria are Diaminopyrimidines
used against? What are they often used in combination with?
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G+ and G- aerobes
Sulfonamides |
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What are the four qualities of Sulfonamide-diaminopyrimidine (Potentiated Sulfonamides) combination?
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-Bactericidal
-Broad spectrum -Reduced resistance -Synergism |
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What are the Potentiated Sulfonamides used against? What are they the drug of choice for?
What other diseases are they used against? |
G+/G- aerobes-cidal
G- prostatitis in dogs and salmonellosis in horses Toxoplasmosis and coccidia |
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Is Metronidazole concentration or time dependent? Static or cidal? Does it cross the BBB?
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Concentration
Cidal (Floro & Aminos too) Yes |
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What is Metronidazole effective against?
What protozoa can it be used to eliminated? |
G+/G- anaerobes & protozoa
Giardia and histomonas |
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What is the mechanism of action of Rifampin? Is it bacteriocidal or bacteriostatic?
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Inhibits RNA polymerase
Cidal |
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Does Rifampin cross the BBB? What is it active against?
What bacteria specifically? What about intracellular activity? |
Yes
Highly active against G+ aerobes R. equi, S. aureus Against chlamydia and rickettsia |
