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16 Cards in this Set
- Front
- Back
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sulfonamides MOA
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1) PABA analog - inhibit DHPS (dihydropteroate synthase) which is required for folic acid synthesis
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sulfonamides are considered to be?
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bacteriostatic
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sulfonamides may displace?
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bilirubin from plasma albumin binding sites
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so, it causes ??? in neonates
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Kernicterus
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sulfonamides may be antagonized by?
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local anesthetics that are esters of PABA (Procaine)
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adverse effects of sulfonamides?
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1) hypersensitivity
2) photosensitivity 3) Stevens-Johnson syndrome 4) crystalluria 5) hemolytic anemia 6) N/V, diarrhea 7) hepatic necrosis 8) blood dyscrasias |
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sulfonamides are DOC for?
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nothing
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sulfonamides are alternate drugs for?
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1) Chlamydia trachomatis
2) Nocardia 3) some UTIs (Bactrim) 4) some N. meningitidis |
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Sulfisoxazole (Gantrisin) with phenazopyridine
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Azogantrisin
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Sulfisoxazone + Erythromycin ethylsuccinate =
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Pediazole
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Sulfamethoxazole (Gantanol) + Trimethoprim =
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Bactrim, Septra (for UTI)
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Silver Sulfadiazine =
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Silvadine (DOC for prevention of burn infe.)
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Sulfadoxine + Pyrimethamine =
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Fansidar (for chloroquine-resistant malaria)
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Sulfacetamide (Sulamyd, Isoptocetamide) + sulfur =
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Sulfacet-R-lotion for acne
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Mafenide (Sulfamylon) for
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to prevent burn infe.
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Trimethoprim-Sulfamethoxazole (Bactrim, Septra) is DOC for?
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1) acute UTI
2) Nocardia 3) Moraxella catarrhalis 4) H. flu 5) Yersinia enterocolitica |
