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15 Cards in this Set
- Front
- Back
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Which sulfa is usually preferred for treatment of UTI's ?
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sulfisoxazole
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Which sulfas can be administered topically ?
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sulfacetamide (Sulamyd)
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What would be aware of when prescribing a topical sulfa ?
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greater risk of hypersensitivity reactions.
-reserved for opthalmic infections, vaginitis, burns |
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What is THE major side effect with sulfas ?
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Stevens Johnson syndrome
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What are the signs and symptoms of Stevens Johnson syndrome ?
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widespread lesions of skin and mucous membranes, fever, malaise, toxemia
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What are some other adverse side effects of sulfas ?
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Hematologic problems
hemolytic anemia in those with G6PD -kernicterus if given to babies < 2 months and to pregnant women -renal damage from the drug crystallizing in the urine |
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Stevens Johnson syndrome is more likely with what type of sulfa?
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longer acting, less soluble sulfas that are no longer on the market
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How do sulfas work ?
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Folic acid inhibition at PABA
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Are sulfas bacteriostatic or cidal ?
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they are bacterioSTATIC
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What is the spectrum of the sulfa drugs ?
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gram positive cocci;
gram negative bacilli chlamydia, toxoplasma, plasmodia |
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What are the two groups of sulfas ?
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sulfas for systemic use and sulfas for local effects
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Short acting sulfas are used primarily to treat ????
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UTI's ==>high water solubility==>less crystallization risk
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Intermediate acting sulfa (Sulfamethoxazole) is used to treat ????
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used primarily in combination with trmethoprim for chronic UTI's
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The two topical sulfas are sulfacetamide and silver sulfadiazine
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and are usedto treat superficial eye infections AND
burns |
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Sulfas are metabolized where >
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in the liver by acetylazation
Excreted by the kidneys. |
