Sublingual And Buccal

Front 1

What's the Buccal?

Back 1

Lining of the cheek. Usually between the cheeks and gums.

Front 2

What's the Sublingual?

Back 2

Ventral surface of the tongue and floor of mouth.

Front 3

What are two general purposes of administering drugs to the oral cavity?

Back 3

To achieve systemic and local effect.

Front 4

What are the intermediate properties of the oral mucosae?

Back 4

Coated w/ mucous, but a squamous epithelium.

Front 5

What's the prinicple barrier for drug absorption?

Back 5

Epithelium

Front 6

What good about the epithelium being highly vascularized?

Back 6

Good for systemic delivery.

Front 7

True/False

Buccal and Sublingual membranes are keratinized.

Back 7

False

NOT Keratinized

Front 8

True/False

Buccal is thicker than sublingual

Back 8

True

2-8 times thicker

Front 9

True/False

Sublingual is more permeable than buccal.

Back 9

True

Front 10

pH of Saliva?

Back 10

about 7

Front 11

What's good and bad about saliva?

Back 11

Good: can dissolve drug

Bad: can wash it away

Front 12

Name a regional difference in the amount of saliva in your mouth.

Back 12

You can a pool of saliva under your tongue.

Front 13

True/False

Disadvantages of sublingual/buccal delivery include: Avoidance of GI acid degrations, GI enzymation and the hepatic first pass effect.

Back 13

False

These are advangtages.

Front 14

In SL/Buccal meds the drainage goes to what vein?

Back 14

Jugular vein

Front 15

True/False

SL/Buccal can only be used for fast action.

Back 15

False

Can be used for both fast and prolonged.

Front 16

Why's there a relatively low permeability for most SL/Buccal drugs?

Back 16

Cuz of skin-like barriers properties

Front 17

Why's there sometimes an unpredictable bioavailabilty for SL/Buccal drugs?

Back 17

Due to mucosal variations.

Front 18

Why are SL drugs designed for rapid drug release over a short period of time?

Back 18

Drug dissolves in pool of saliva and must be quicly absorbed before being washed away.

Front 19

Generally, why are buccal designed for slower drug release?

Back 19

Buccal has lower permeability and it's relatively easy to keep dosage form in place.

Front 20

Why should SL and Buccal be bland and non-irritating?

Back 20

So as not to stimulate saliva flow.

Front 21

Why are SL tabs lightly compressed?

Back 21

To facilitate disintegration.

Front 22

Besides serving as a diluent, what's another purpose of lactose for SL NTG tabs?

Back 22

Adsorption of NTG to lactose: reduces volatility and explosive risk!

Front 23

How are molded tabs prepared?

Back 23

By forcing moistened blend of drug and excipents into a mold, followed by forcing the wet mass of out of the mold and allowing to dry.

Front 24

True/false

Compressed tabs are softer than molded tabs.

Back 24

False

Molded tabs are softer than compressed.

Front 25

Molding Tablets:

What does Polyethylene glycol do when used to produce NTG?

Back 25

Lowers vapor pressure.

Front 26

Why are NTG dried under ambient conditions?

Back 26

To limit NTG evaporation.

Front 27

True/False

NTG is best packaged in plastic containers.

Back 27

False

They should be packaged in GLASS because they interact and pass thru plastic.

Front 28

How long can you keep NTG after it's been opened?

Back 28

6 months.

NTG slowly evaporates after opening.

Front 29

True/False

Nitrolingual spray has a long shelf-life.

Back 29

True!

Front 30

What's an advantage of nicotine being used for buccal administration instead of tablet form?

Back 30

Nicotine has a high hepatic first pass effect.

Front 31

True/False

Nicotine is exhanged w/ saliva cations.

Back 31

True

and chewing is critical!

Front 32

Why's is nicotine formulated w/ a buffer to raise the pH to 8.5?

Back 32

It increases the nonionized form and increases absorption.

Front 33

True/false

The systemic bioavailability of nicotine depends on the time the saliva is held in the mouth.

Back 33

True

if swallowed, nicotine is hepatically metablized.

Front 34

Why are lozenges typically prepared like hard candy?

Back 34

To Dissolve slowly in the mouth.

Front 35

True/False

Nicotine, but not nicorette, is bound to a cation exchange resin.

Back 35

False

Both are bound to a cation exchange resin.

Nicotine is the lozenge.

Nicorette is the chewing.

Front 36

Actiq or fentanly citrate is hydrophillic and have a low hepatic 1st pass effect.

Back 36

False

It is LIPOphillic and has a HIGH hepatic AND intestinal first pass effect

Front 37

True/False

Fentanly lollipop is placed ontop of the tongue and sucked.

Back 37

FALSE

It's placed between the cheek and gums then sucked for about 15 min.

Front 38

Where's the rapid absorption in fentanyl lollipops?

the slow absorption?

Back 38

1st it's rapid absorption in the mouth and 2nd prolonged absorption from the GI.

Front 39

What's a nice feature of the lollipops?

Back 39

They are unlikely to be swallowed and can be easily removed if there are side effects.

Front 40

Why should you dispose of the lollipops properly?

Back 40

So kids can't get them.

Front 41

What's the goal of mucoadhesive tablets?

Back 41

To keep in place!

Front 42

What's the excipient that helps keep the mucoadhesive tabs in place?

Back 42

cellulose derivatives

Front 43

What's Striant?

Back 43

A testosterone buccal system.

Front 44

Why's Striant benefical as a buccal form?

Back 44

Testorone has a high hepatic 1st pass effect and the tab can stay in place until removed (about 12 hrs).

Front 45

Other than Striat give another example of a mucoadhesive tablet.

Back 45

Nitrogard (nitroglycerin)

Front 46

True/False

All orally disinterating tablets are meant for GI absorption.

Back 46

False

Some are meant for oral absorption.

Front 47

Give and example of an orally disinterating tablet.

Back 47

Zelapar - Selegiline HCl

Used for Parkinson's

Front 48

How's Zelepar prepared?

Back 48

Lyophilization

Front 49

True/False

Zelepar, a buccan tab, is placed on the tongue where it's dissolved.

Back 49

True

Absorption is buccal

Avoid food and liquid 5 min before and after.