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5 Cards in this Set
- Front
- Back
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four major protein secretion pathways from the Golgi
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apical plasma membrane
basolateral plasma membrane endosomes/lysosomes apical cytoplasm |
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describe the apical plasma membrane
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constitutive
Non-Clathrin sorting signals - linear arrays of amino acids / associated glyosylations sorting happens in the TGN |
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basolateral plasma membrane
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constitutive
sorting signal HAPPENS at TGN << clathrin-coated vesicles with epithelium-specific adapter protein |
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endosomes/lysosomes describe.
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M6P added to the protein in ER to target it to the lysosome
membrane proteins may be targeted directly TO lysosome or FIRST travel to cell surface and to lysosome through the endosomal pathway |
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describe apical cytoplasm
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aggregated or crystallized in TGN because of changes in pH and [Ca2+]
stored in large secretory vesicles vesicles release contents via exocytosis |
