Stroke, Hit, And Valvular Heart Disease

Front 1

Recommendation for aspirin if being given in VAF

Back 1

if low risk of bleeding, 3 months with warfarin

Front 2

INR goal for VAF

Back 2

2.5-3.5

Front 3

Which DOAC indicated for VTE ppx of AMI?

Back 3

betrixaban

Front 4

AEs of heparin:

Back 4

bleeding, injection site reaction, HIT, hyperkalemia

Front 5

Monitoring for heparin:

Back 5

antiXa, apTT/PTT, CBC at baseline

Front 6

Contraindications for UFH:

Back 6

hx/sus of HIT

Front 7

Reversal for UFH:

Back 7

protamine sulfate 1mg/100 units (works in 5 min)

Front 8

AEs of LMWH:

Back 8

bleeding, injection site reaction, HIT (less than UFH)

Front 9

Monitoring for LMWH:

Back 9

antiXa, aPTT, CBC at baseline, SCr at baseline

Front 10

LMWH Contraindication(s):

Back 10

hx/sus of HIT, <50kg body weight

Front 11

Reversal for LMWH:

Back 11

protamine sulfate (off-label) reverses 60%

Front 12

Which heparin product is safe in pregnancy:

Back 12

LMWH

Front 13

SQ Enoxaparin VTE treatment doses:

Back 13

1mg/kg q12 or 1.5mg/kg q24

Front 14

Which heparin(s) renally adjusted?

Back 14

LMWH and fondaparinux

Front 15

SQ Enoxaparin for VTE treatment for renal dose;

Back 15

if CrCl<30 1mg/kg q24

Front 16

SQ enoxaparin for VTE ppx:

Back 16

2.5mg daily

Front 17

Rank heparins in order of increasing T1/2:

Back 17

UFH, LMWH, fondaparinux

Front 18

Does protamine sulfate work for fondaparinux?

Back 18

No

Front 19

Safest DOAC in CKD/AKI patients:

Back 19

apixaban

Front 20

Metabolism/interaction potential enzymes for FXa inhibitors:

Back 20

3A4 and PGP

Front 21

metabolism/interaction potential enzymes for FIIa inhibitor :

Back 21

PGP

Front 22

S-warfarin (super warfarin) metabolized by:

Back 22

2C9 (primary)

Front 23

L-warfarin (lazy warfarin) metabolized by:

Back 23

all others (2C8, 2C19, 3A4)

Front 24

Full onset of action for warfarin occurs in:

Back 24

5-7 days

Front 25

Protein binding for warfarin in the blood:

Back 25

99%

Front 26

Dose reduction in Eliquis for any 2 / 3:

Back 26

Scr≥1.5, ≤60kg, ≥80 y/o

Front 27

Before starting edoxaban for stroke ppx:

Back 27

LMWH 5-10 days

Front 28

Avoid which DOAC if CrCl>95:

Back 28

edoxaban

Front 29

Only approved for VTE ppx in AMI:

Back 29

betrixaban

Front 30

Monitoring for DOACs:

Back 30

baseline (CBC, Scr, LFT)

Front 31

2 Cautions and 1 contraindication for DOACs:

Back 31

mechanical valve contraindication, don’t use in pregnancy, certain drugs onboard

Front 32

Renal dosing consideration for UFH :

Back 32

considered safe

Front 33

Renal dosing consideration for LMWH:

Back 33

CrCl<30: dose reduction

Front 34

Renal dosing consideration for warfarin:

Back 34

considered safe

Front 35

Renal dosing consideration for edoxaban:

Back 35

don’t use if CrCl<15 or >95

Front 36

Before starting Pradaxa for VTE Tx :

Back 36

5-10 days of LMWH

Front 37

Which two DOACs require 5-10 days of LMWH:

Back 37

edoxaban (Savaysa) and dabigatran (Pradaxa)

Front 38

Reversal for Pradaxa :

Back 38

idarucizumab(PRAxbind)

Front 39

Phenytoin is primarily metabolized (90%) by :

Back 39

2C9

Front 40

Phenytoin STRONGLY induces:

Back 40

PGP, 3A4,, 1A2, 2C9,19