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32 Cards in this Set
- Front
- Back
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dosage of nmbd to facilitate tracheal intubation
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2*ED95
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generic term for nmb
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Chirari
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what does ed95 represent?
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dosage that will illicit single twitch response in 95% of pts.
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what is "good enough" for surgical conditions?
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90% suppression of single twitch response
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Dosage for larygospasm
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sux .1mg/kg iv or 20mg/1cc
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clinical uses for nmbd
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tracheal intubation,improve surgical conditions, stop laryngospasm,mechanical vent of lungs
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only nondepolarizing nmb that mimics sux but has prolonged effect
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roc
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do we usu measure the ulnar or facial nerve?
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ulnar
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how is equal potency determined?
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by measuring the dose needed to suppress 95% of a single twitch
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intubating dose is
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2*ED95
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do potency of volatiles increase or decrease dose of nmb?
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need less
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does the ulnar nerve correlate well with larynx?
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no;by the time u lose twitches at ulnar nerve, larynx is relaxed
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order of relaxation of diaphragm, eyes, pharynx from first to last
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eyes, pharynx, diaphragm
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order of recovery of diaphragm, eyes, pharynx
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diagphragm,pharynx, eyes
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best monitor of blockade if we want to monitor just the larynx?
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obicularis occuli
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why do nmb have a limited volume of distribution?
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they are highly ionized and have limited lipid solubility; water soluble (quartenary amoniums)
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do volatile agents prolong or decrease block?
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prolong
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which nmb should u not use w/pt with esrd?
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pancuronium (80% eliminated in kidney unchange)
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which nmbd has the highest biliary excretion unchanged?
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vec (40-75) roc (50-70)
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which 2 nmb undergo hydrolysis in plasma?
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mivicurium,atracurium
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name the benzilisoquinolium drugs and the aminosteroid drugs
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aminosteriods:ronium (pan,vec,
benzilisoginolium:curium (atra, cis,mubiv) |
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compare onset of action of sux and pancuronium
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sux: 60 sec; pancuronium: bmv for 5 minutes
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Is atracurium dependent on renal or hepatic function?
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no; neither one. undergoes hoffman elimination/plasma degradation
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is vecuronium dependent on renal or hepatic function?
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yes and yes. (more on liver, i think)
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is rocuronmium dependent on liver or hepatic fx?
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yes and yes(more on liver i think.
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Is Cis hydrolosized in the plasma?
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no; undergoes hoffman elimination
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Is Cis dependent of kidney or liver fx?
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no
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how do non depolarizing vs polarizing work?
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depolarizing mimic ach; nondepolarizers block ach
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which ndpd has longest onset?
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pancurionium
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rocs intubating dose
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.6-1.2mg/kg
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what is intubating dose?
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2*ED 95
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What is roc's RSI dose?
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1.2 mg/kg
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