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47 Cards in this Set
- Front
- Back
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Pulmonary hemorrhage
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Goodpasture
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HLA in Goodpasture
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DR2
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Other dzs that share Goodpasture's HLA
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DR2: MS, SLE, hay fever
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Treatment for Goodpasture:
Steroids + what (2)? |
Cytoxan
Plasmapheresis to remove circulating Abs |
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Pathology findings in giant cell arteritis
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Granulomatous inflammation of internal elastic lamina
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Pt complaints in giant cell arteritis
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-Vision changes
-Headache -Jaw claudication -Head tenderness |
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Condition associated with 1/2 of giant cell arteritis pts
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Polymyalgia rheumatica
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Inflammation of sm-med sized arteries, typically affecting skin, peripheral nn, kidneys, joints, GI
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Polyarteritis nodosa
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Pathology findings in polyarteritis nodosa
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Transmural necrotizing inflammation of sm-med arteries
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What happens to arteries in polyarteritis nodosa?
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-Wall thickening
-Luminal obstruction -Aneurysm formation -Downstream ischemic change |
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-Palpable purpura
-Tender nodular lesions -Livedo reticularis -Infarcts of fingertips -Peripheral neuropaty -HTN with renal sediment abnl -Orchitis |
Polyarteritis nodosa
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HBsAg
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Polyarteritis nodosa
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Other name for Buerger dz
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Thromboangiitis obliterans
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Segmental vascular inflammation w/o atheromas
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Buerger
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Smoking
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Buerger
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Distal extremity:
-Iischemia -Claudication -Pain at rest |
Buerger
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Raynaud and gangrene
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Buerger
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Pulseless disease
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Takayasu arteritis
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Pathology findings in Takayasu
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Granulomatous inflammation of large aa
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Inflammation may cause ischemic changes (TIA, stroke, visual disturbances chest pain)
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Takayasu
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Young women
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Takayasu
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Dx made when a mediastinal mass is suspected
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Takayasu
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BP difference between arms
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Takayasu
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Pathology findings in Wegener's granulomatosis
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Small vessel necrotizing vasculitis in resp tracts with extravascular granulomatous inflammation
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When do renal sx present in Wegener's
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Uremia - it's already too late!
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This vasculitis is non-discriminating in age-sex-race
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Wegener
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-Chronic sinusitis
-Epistaxis -Mucosal ulcerations -Oral ulcers -Otitis media |
Wegener
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Wegener is commonly misdx'ed as this
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Respiratory problem - allergies or infection
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Antibody finding in Wegener
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c-ANCA
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Wegener pts are at risk for what infection?
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PCP, prevent it with Bactrim
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Vasculitis associated with asthma
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Churg-Strauss
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Pathology findings in Churg-Strauss
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Small-med vessel necrotizing vasculitis
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-Asthma
-Palpable purpura -Subcutaneous nodules |
Churg-Strauss
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Antibody finding in Churg-Strauss
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p-ANCA
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Peripheral eosinophilia
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Churg-Strauss
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Diagnostic criteria for Kawasaki
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-5d of fever
-Conjunctivitis -Cracking/fissuring of lips w/ mucosal inflamm -Unilateral cervical LAD -Rash -Erythema on hands/feet --> desquamation |
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Leading cz of acquired cardiac dz in kids
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Kawasaki
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In kids - a fever that is unresponsive to abx.
Should think what? |
Kawasaki
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IVIG and high-dose ASA are tx for?
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Kawasaki
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Cardiac complications in Kawasaki
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Coronary artery aneurysms
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-Colicky abd pain
-Arthritis -Hematuria |
Henoch-Schonlein purpura - will also see palpable purpura
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Vessels affected by Henoch-Schonlein purpura
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Small vessels
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Pathophysiology of Henoch-Schonlein purpura
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IgA-C3 immune complex deposition
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This vasculitis involves skin, CT, joints, kidneys, GI, scrotum
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Henoch-Schonlein purpura
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What d/o is related to Henoch-Schonlein purpura?
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IgA nephropathy - HSP involves organs other than the kidney and mostly kids (IgA mostly in adults)
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Hx: preceding URI
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Henoch-Schonlein purpura
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Hx: testicular swelling, bloody stool
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Henoch-Schonlein purpura
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