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50 Cards in this Set
- Front
- Back
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Receptors expressed on Cytotoxic T Cell
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TCR
CD3 CD8 |
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Receptors expressed on Helpter T Cell
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TCR
CD3 CD4 CD28 CD40L |
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What IL stimulates TH1 differentiation?
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IL-12
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What IL stimulates TH2 differentiation?
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IL-4
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What mediators are made by TH1
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IL-2 (+Th and Cytotoxic T Cells)
IFN-Gamma Inhibited by IL-10 (Th2) |
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What mediators are made by Th2?
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IL-4, IL-5, IL-10
Inhibited by IFN-Gamma |
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Interactions required for Th activation
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MHCII:TCR
B7:CD28 IL-2 (from self) |
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Interactions required for Tc activation
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MHCI:TCR
IL-2 from Th |
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Interactions required for B Cell activation
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IL-4, IL-5, IL-6 from Th2
CD40L:CD40 |
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Pepsin
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Cleaves Ab below hinge to generate 2 fragments
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Papain
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Cleaves Ab at hinge region to generate 3 fragments
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Order of Heavy Chain Genes
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My Dear Great (G3) Grandma and Great Grandpa Eat Apples
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IL-1
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Macrophages
Acute inflammation Endogenous Pyrogen |
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IL-2
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Th Cells
Growth of Th and Tc cells |
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IL-3
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T Cells
Stimulates Bone Marrow like GCSF |
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IL-4
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Th2 Cells
Growth of B Cells Class Switching to IgE and IgG |
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IL-5
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Th2 Cells
Differentiation of B Cells Class Switching to IgA Stimulates Eosinophils |
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IL-6
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Th cells and macrophages
Stimulates Acute Phase Reactants Stimulates Igs |
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IL-8
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Macrophages
Chemotactic for neutrophils Clean up on Aisle 8 |
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IL-10
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Regulatory T Cells (Th2)
Inhibits activated T Cells |
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IL-12
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B Cells and Macrophages
Activates NK and Th1 |
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IFN-Gamma
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Th1 Cells
Stimulates macrophages |
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TNF
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Macrophages
Recruits leukocytes Mediates septic shock |
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ANA
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SLE
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Anti-dsDNA
Anti-Smith |
SLE (specific)
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Antihistone
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Drug-induced lupus
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Anti-IgG
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Rheumatoid Factor
Rheumatoid Arthritis |
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Anticentromere
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CREST scleroderma
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Anti-Scl-70
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Diffuse scleroderma
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Antimitochondrial
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Primary Biliary Cirrhosis
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Antigliadin
Antiendomysial |
Celiac Disease
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Anti-basement membrane
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Goodpasture's syndrome
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Anti-desmoglein
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Pemphigus Vulgaris
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Antimicrosomal
Antithyroglobulin |
Hashimoto's Thyroiditis
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Anti-Jo-1
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Polymyositis
Dermatomyositis |
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Anti-SS-A (Anti-Ro)
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Sjogren's syndrome
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Anti-SS-B (Anti-La)
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Sjogren's syndrome
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Anti-U1 RNP (ribonucleoprotein)
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Mixed connective tissue disease
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Anti-smooth muscle
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Autoimmune Hepatitis
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Anti-glutamate decarboxylase
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Type 1 diabetes mellitus
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c-ANCA
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Wegener's Granulomatosis
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p-ANCA
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Microscopic polyangiitis
Pauci-immune Crescentic GN Churg-Strauss syndrome |
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HLA A3
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Hemochromatosis
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HLA B27
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Psoriasis
Ankylosing Spondilitis Inflammatory Bowel Disease Reiter's syndrome |
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HLA B8
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Grave's Disease
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HLA DR2
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Multiple Sclerosis
Hay Fever SLE Goodpasture's syndrome |
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HLA DR3
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Diabetes mellitus type 1
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HLA DR4
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Rheumatoid Arthritis
Diabetes Mellitis type 1 |
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HLA DR5
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Pernicious Anemia (B12 Def.)
Hashimoto's Thyroiditis |
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HLA DR7
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Steroid Responsive Nephrotic Syndrome
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