Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
30 Cards in this Set
- Front
- Back
|
Mannitol MOA
|
-osmotic diuretic (proximal tubule)
|
|
|
Mannitol location of action
|
proximal tubule
|
|
|
Mannitol uses
|
-drug OD
-elevated ICP, IOP |
|
|
Mannitol OD
|
-pulmonary edema
-dehydration do NOT use w/ CHF, anuria |
|
|
Acetazolamide MOA
|
(-) carbonic anhydrase ---> cannot resord HCO3- in PT
|
|
|
Acetazolamide Uses
|
-alkalinize urine (salicylate OD, uric acid or cysteine stones)
-metabolic alkalosis / altitude sickness -pseudomotor cerebri -glaucoma |
|
|
Acetazolamide location
|
Proximal tubule
(-) carbonic anhydrase |
|
|
Acetazolamide OD
|
-hyperChloremic metabolic ACIDosis
-paresthesias -sulfa allergy |
|
|
Tx uric acid stones
|
Acetazolamide
|
|
|
Tx cysteine stones
|
Acetazolamide
|
|
|
Furosemide MOA
|
Loop Diuretic (Thick AL)
(-) TriTransporter---> (Na+, K+, Cl-) destroys hypertonicity of medulla increase PGE release ---> dilate afferent arteriole increase Ca2+ excretion |
|
|
DOC hypercalcemia
|
Furosemide
|
|
|
causes hypersensitivity to sulfa drugs
|
Acetazolamide
Furosemide |
|
|
Furosemide OD
|
-ototoxicity
-hypokalemia -dehydration -allergy (sulfa) -Nephritis -Gout OH DANG |
|
|
diuretic causing ototoxicity
|
Furosemide
|
|
|
Loop diuretics
|
Furosemide
Ethacrynic acid |
|
|
diuretic causing gout
|
Loop Diuretics
-Furosemide -Ethacrynic acid |
|
|
diuresis in pts. w/ sulfa drugs
|
Ethacrynic acid (loop diuretic)
(Furosemide, thiazide and Acetazolamide cause sulfa allergies) |
|
|
Hydrochlorothiazide MOA
|
(-) NaCl reabsorption (early distal tubule)
-lower Ca2+ excretion |
|
|
diuretic stimulating PGE
|
Furosemide (loop diuretic/ K+ wasting)
PGE will relax Afferent arteriole----> increase RPF |
|
|
DOC idiopathic hypercalciuria
|
Thiazides
|
|
|
Tx nephrogenic DI
|
THiazides
|
|
|
Thiazides OD
|
-hypokalemic metabolic alkalosis
-hyponatremia HyperGLUC -hyperglycemia -hyperlipidemia -hyperuricemia -hypercalcemia -sulfa allergy |
|
|
K-wasting diuretics
|
Furosemide
Ethacrynic acid Thiazides |
|
|
K-sparing diuretics
|
Spirinolactone / Eplerenone
Triamterene Amilioride |
|
|
Eplernone
|
same MOA as Spirinolactone
competitive Aldosterone rec. antagonists fewer endocrine S/E than Spirinolactone |
|
|
Spirinolactone w/o endocrine S/E
|
Eplerenone
|
|
|
Triamterene MOA
|
block Na+ channels in CT
(same as Amiloride) |
|
|
Amiloride
|
block Na+ channels in CT
(same as Triamterene) |
|
|
Sprinolactone S/E
|
-gynecomastia/ hirsituism
-hyperkalemia |
