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33 Cards in this Set
- Front
- Back
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Tumor Marker:
PSA |
-Prostate-specific Ag
-screens for prostate carcinoma -also (+) for BPH and prostatitis NOT 1' TOOL FOR Dx |
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Tumor Marker:
CEA |
Carcinoembryonic Ag
-very non-specific -produced by 70% colorectal and pancreatic cancers -gastric, breast, thyroid medullary carcinomas |
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Tumor Marker:
AFP |
alpha-fetoprotein
-normally a FETAL protein -hepatocellular carcinomas -nonseminomatous germ cell tuors (esp. YOLK CELL) |
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Tumor Marker:
beta-hCG |
-Hydatiform moles
-Choiriocarcinomas--> Germ-Cell Testicular Tumor -Gestational trophoblastic tumors |
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Tumor Marker:
CA-125 |
-oviarian tumors
-malignant epithelial tumors |
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Tumor Marker:
S-100 |
-melanoma
-neural tumors -astrocytomas |
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Tumor Marker:
Alkaline Phosphatase |
-Padgets disease
-bone mets. -obstructive biliary disease |
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Tumor Marker:
Bombesin |
-neuroblastoma
-lung cancer -gastric cancer |
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Tumor Marker:
TRAP |
-Hairy Cell Leukemia (BC neoplasm)
(trap the hairy animal) |
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Tumor Marker:
CA-19-9 |
Pancreatic adenocarcinoma
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Tumor Marker:
Calcitonin |
Thyroid medullary carcinoma
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Tumor Marker:
PLAP |
Germ Cell Tumors
Seminoma |
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Genes:
abl |
CML Oncogene
Philidelphia Chromosome--> TK always on |
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Genes:
c-myc |
Burkitt's Lymphoma Oncogene
-increased transcription factor -t (8,14) -t (8, 22) – lambda -t (8, 2)- kappa STARRY SKY MACROPHAGES |
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Philidelphia Chromosome
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t (9; 22)
-CML--> activated tyrosine kinase -Tx: Imatinib (Gleevec) |
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Genes:
bcl-2 |
anti-apoptotic molecule (INTRINSIC PATHWAY)
FOLLICULAR AND UNDIFFERENTIATED LYMPHOMAS |
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Genes:
erb-B2 |
Breast cancer
Ovarian Cancer Gastric Carcinomas |
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Genes:
ras |
Colon carcinoma oncogene
GTPase |
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Genes:
L-myc |
Lung tumor Oncogene
Transcription factor |
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Genes:
N-myc |
Neuroblastoma
Transcription Factor |
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Genes:
ret |
multiple endocrine neoplasia (MEN)
types IIA and IIB Tyrosine kinase |
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Genes:
c-kit |
Gastrointestinal stromal tumors (GIST)
cytokine receptors |
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Tumor Suppressor Genes:
Rb |
-retinoblastoma
-osteosarcoma blocks G1--> S phase |
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Tumor Suppressor Genes:
p53 |
-most cancers
-Li-Fraumeni Syndrome blocks G1--> S phase |
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Tumor Suppressor Genes:
BRACA1 |
-breast cancer
-ovarian cancer -DNA REPAIR protein |
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Tumor Suppressor Genes:
BRACA2 |
-breast cancer
-DNA REPAIR protein |
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Tumor Suppressor Genes:
p16 |
melanoma
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Tumor Suppressor Genes:
APC |
colorectal cancer
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Tumor Suppressor Genes:
WT1 |
Wilm's Tumor
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Tumor Suppressor Genes:
NF1 |
Neurofibromatosis type 1
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Tumor Suppressor Genes:
NF2 |
Neurfibromatosis type 2
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Tumor Suppressor Genes:
DPC |
pancreatic cancer
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Tumor Suppressor Genes:
DCC |
colon cancer
(also APC tumor suppressor gene) |
