Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
32 Cards in this Set
- Front
- Back
|
Cell Markers:
c-kit |
GIST
Gastrointestinal Stromal Tumor (cytokine receptor) |
|
|
Cell Markers:
ret |
Multiple-Endocrine Neoplasia 2A + 2B
MEN-2A/ MEN-2B (tyrosine kinase) |
|
|
Cell Markers:
N-myc |
Neuroblastoma
(transcription factor) N is for NEURO |
|
|
Cell Markers:
L-myc |
Lung tumors
(transcription factor) L is for LUNG |
|
|
Cell Markers:
ras |
Colon adenosarcoma
(GTPase) |
|
|
Cell Markers:
HER2/ neu |
Breast, ovarian, and gastric carcinomas
(tyrosine kinase) |
|
|
Cell Markers:
bcl-2 |
Follicular and undifferentiated lymphomas
(anti-apoptotic) |
|
|
Cell Markers:
c-myc |
Burkitts Lymphoma
(transcription factor) |
|
|
Cell Markers:
abl |
CML
(tyrosine kinase) |
|
|
Tumor Suppressor Genes:
Rb |
Retinoblastoma, osteosarcoma
-inhibits E2F -blocks G1-->S phase |
|
|
Tumor Suppressor Genes:
p53 |
most human cancers, LiFraumeni syndrome
-transcription factor for p21 -blocks G1-->S phase (LiFraumeni has "meni" tumors) |
|
|
Tumor Suppressor Genes:
BRAC1 BRAC2 |
Breast and ovarian cancers
-DNA repair proteins |
|
|
Tumor Suppressor Genes:
p16 |
melanoma
-also BRAF |
|
|
Tumor Suppressor Genes:
BRAF |
melanoma
-also p16 |
|
|
Tumor Suppressor Genes:
APC |
Colorectal cancers
(associated with FAP) |
|
|
Tumor Suppressor Genes:
WT1 |
Wilm's tumor
(nephroblastoma) WT= Wilm's Tumor |
|
|
Tumor Suppressor Genes:
NF1 |
Neurofibromatosis Type 1
-RAS GTPase activating protein |
|
|
Tumor Suppressor Genes:
NF2 |
Neurfibromatosis Type 2
-Merlin (schwannomin) protein |
|
|
Tumor Suppressor Genes:
DPC4 |
Pancreatic cancer
DPC(4) = Deleted in Pancreatic Cancer |
|
|
Tumor Suppressor Genes:
DCC |
Colon cancer
DCC= Deleted in Colon Cancer |
|
|
Tumor Markers:
PSA |
Prostate Specific Antigen
-benign prostatic hyperplasia -prostate cancer -prostatitis (screening debatable--> def. use for recurrance) |
|
|
Tumor Markers:
Prostatic Acid Phosphatase |
Prostate cancer
-PSA is non-specific for prostate cancer--> also in BPH and prostatitis |
|
|
Tumor Markers:
CEA |
CarcinoEmbryonic Antigen
-very non-specific -70% colon cancers, pancreatic cancers -gastric, breast, medullary thyroid carcinomas |
|
|
Tumor Markers:
alpha-Fetoprotein |
-normally made by fetus
-hepatocellular carcinomas -non-seminomatous germ cell tumors TRIPLE SCREEN (16-18wk. gestation) -high = multigestation, neural tube defect, GI wall defect -low = Down's Syndrome |
|
|
Tumor Markers:
beta-hCG |
-hydatiform moles
-choriocarcinomas -normally made by synchitiotrophoblst |
|
|
Tumor Markers:
CA-125 |
-ovarian cancer
-screen for recurrence only |
|
|
Tumor Markers:
S-100 |
-melanoma
-neural tumors -schwannomas (note: all of these are neural crest derivatives = S-100) |
|
|
Tumor Markers:
Alkaline Phosphatase |
-mets to bone, liver
-Padget's disease of bone -when hepatic origin, may indicate obstruction--> look at GTT for more specific marker |
|
|
Tumor Markers:
Bombesin |
Bombesin
-neuroblastoma -gastric carcinoma -lung cancer |
|
|
Tumor Markers:
TRAP |
Tartrate-Resistant Acid Phosphatase
Hairy-Cell Leukemia = B-cell neoplasm (TRAP the Hairy animal) |
|
|
Tumor Markers:
CA-19-9 |
CA-19-9
-Pancreatic adenocarcinoma -may also look for CEA, but less specific (colon, breast, medullary thyroid cancers) |
|
|
Tumor Markers:
Calcitonin |
Medullary thyroid carcinoma
-CEA also (+), but less specific |
