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25 Cards in this Set
- Front
- Back
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Prevalence
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Prevalence = Incidence x Duration
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Sensitivity
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dz+/test+ divided by total dz+
True positive ratio a/(a+c) |
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Specificity
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dz-/test- divided by total dz-
True Negative ration d/(b+d) |
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Positive Predictive Value
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dz+/test+ divided by total test+
a/(a+b) |
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Negative Predictive Value
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dz-/test- divided by total test-
d/(c+d) |
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Odds ratio
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odds of having disease in exposed group divided by odds in unexposed group
quantitate how odds change with exposure (a:b)/(c:d) |
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Relative Risk
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dz risk in exposed group divided by dz risk in unexposed group
a/(a+b)/c/(c+d) |
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Attributable risk
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a/(a+b) - c/(c+d)
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Confidence interval
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mean +/- 1.96(SEM)
SEM = (std dev)/sqrt(n) |
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Metabolism of FA
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Acyl CoA prod = -2 ATP
Acyl CoA to Acyl CoA and Acetyl CoA = 5 ATP Acetyl CoA in TCA cycle = 12 ATP |
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Cardiac Output
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O2 consumption/(PaO2-PvO2)
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Mean Arterial Pressure
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MAP = CO x TPR
MAP = 0.3 Systolic P + 0.6 Diastolic P |
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Stroke Volume
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CO/HR or ESV-EDV
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Ejection Fraction
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SV/EDV
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Glomerular Filtration Rate
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GFR = CL|inulin
GFR = (Ui x V)/Pi |
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Effective Renal Plasma Flow
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ERPF = CL|pah
ERPF = (Upah x V)/Ppah ERPF is essentially RPF RBF = RPF/(1-Hct) |
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Volume of distribution
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Vd = amt drug in body/plasma concentration
[mL] assume concentration is same in all body compartments |
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Vd for plasma bound drugs
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Vd = 0.03 L/kg << plasma volume
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Vd for lipid soluble drugs
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Vd . 10 L/kg > plasma volume
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Clearance
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CL = rate of elim/plasma concentration
CL = ke/plasma concentration [mL] hypothetical volume completely cleared of drug per unit time |
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Half-life
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t1/2 = 0.7(Vd)/CL
3.3 half-lives to get to 90% of Loading dose 6-7 half-lives to get to 100% |
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Loading dose
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LD = target plasma concentration x Vd/F
used to reach Tx dose quickly (antidotes) |
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Maintenance dose
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MD = target plasma concentration x CL/F
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Enzyme kinetics: Vo
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Vo = Vmax[S]/(Km+S)
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Lineweaver-Burke plot: (1/Vo)
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(1/Vo) = (Km/Vmax)(1/S) + (1/Vmax)
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