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20 Cards in this Set
- Front
- Back
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221. CCS tip:mixing study is the first test to determine the difference between a clotting factor deficiency in a factor inhibitor antibody.
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a. The aPTT will correct to normal with a clotting factor deficiency.
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222. Presentation of factor VIII deficiency?
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a. Joint bleeding or hematoma in a male child.
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223. Presentation of factor IX deficiency?
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a. Join bleeding or hematoma; less common than factor VIII deficiency.
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224. Presentation of factor XI deficiency?
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a. Rare bleeding with trauma or surgery.
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225. Presentation of factor XII deficiency?
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a. No bleeding.
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226. Diagnostic test for factor 8 deficiency?
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a. Mixing study first, then specific factor level.
b. This is the same for all factor deficiencies. |
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227. Treatment of factor 8 deficiency?
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a. Severe deficiency: (<1% activity)-factor 8 replacement.
b. Minor deficiency: DDAVP (Desmopressin). |
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228. Treatment of factor 9 deficiency?
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a. Factor nine replacement.
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229. Treatment of factor 11 deficiency?
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a. Fresh frozen plasma with bleeding episodes.
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230. Treatment of factor 12 deficiency?
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a. No treatment necessary.
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231. A woman presents of bleeding into her thigh after minor trauma. The aPTT is prolonged, and the prothrombin time is normal. Mixing study does not correct the aPTT to normal. What is the diagnosis?
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a. Factor 8 antibody- is the most common cause of a prolonged aPTT and bleeding that does correct with a mixing study.
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232. Presentation of heparin induced thrombocytopenia (HIT)?
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a. HIT presents with a drop in platelets (at least 50%) a few days after the start of heparin.
b. This can be from any amount of heparin, no matter how small, because HIT is an allergic reaction. c. Thrombosis is the most common clinical manifestation. d. Venous thromboses are three times more common in arterial thromboses. e. Although low molecular weight heparin is less likely to cause HIT, both types of heparin and can do so. |
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233. What are the best initial diagnostic tests for HIT?
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a. Platelet factor for anybodies
or b. heparin-induced antiplatelet antibodies |
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234. treatment of HIT?
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a. Stop the heparin and
b. use a direct thrombin inhibitor, such as argatroban or lepirudin. |
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235. Note: If HIT happens with IV unfractionated heparin, do not answer “switch to low molecular weight heparin.”
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Note: If HIT happens with IV unfractionated heparin, do not answer “switch to low molecular weight heparin.”
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236. presentation of lupus anticoagulant or lupus anticardiolipin antibodies?
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a. Venous thrombosis
b. Elevated aPTT with a normal PT c. spontaneous abortion d. false positive VDRL |
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237. diagnostic test for lupus anticoagulant or lupus anticardiolipin antibodies?
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a. Mixing study first.
b. Russell viper venom test is most accurate for lupus anticoagulant. |
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238. Treatment of lupus anticoagulant or lupus anticardiolipin antibodies?
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a. Heparin followed by warfarin.
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239. Presentation of protein C deficiency?
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a. Skin necrosis with the use of warfarin.
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240. Diagnostic test for protein C deficiency?
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a. Protein C level.
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