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20 Cards in this Set
- Front
- Back
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141. treatment of CLL?
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a. Entirely based on this stage of the disease.
b. Early disease (stages 0 and 1)- does not require therapy. c. More advanced stages are treated with fludarabine combined with rituximab. d. Chlorambucil is not as effective. e. If the question asks, “which therapy is most likely to extend survival?” The answer is fludarabine for advanced stage disease. |
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142. Note: In CLL, rituximab and significant benefit to fludarabine.
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Note: In CLL, rituximab and significant benefit to fludarabine.
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143. Alemtuzumab MOA and utility?
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a. Anti-CD 52 agent
b. used for CLL (better than chlorambucil) |
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144. presentation of hairy cell leukemia?
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a. Pancytopenia
b. massive splenomegaly c. middle-aged patient (50s) |
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145. what is the most accurate test for hairy cell leukemia?
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a. Tartrate resistant acid phosphatase (TRAP), smear, showing hairy cells.
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146. Best initial therapy for hairy cell leukemia?
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a. Cladribine (2-CDA).
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147. Presentation of myelofibrosis?
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a. Presents the same way as hairy cell leukemia (pancytopenia and splenomegaly)
b. with a normal TRA P level. c. A key feature is teardrop shaped cells on the smear. |
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148. Treatment of myelofibrosis?
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a. Bone marrow transplantation can be curative.
b. When transplant is not possible, “the best initial therapy” is lenalidomide or thalidomide. |
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149. Presentation of polycythemia vera (Pvera)?
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a. Headache
b. blurred vision c. dizziness d. fatigue e. Pruritus, described as happening after a hot bath or shower, also occurs from the release of histamine from basophils. f. Splenomegaly is common |
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150. Note: do not treat asymptomatic elevations and white count caused by CLL.
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Note: do not treat asymptomatic elevations and white count caused by CLL.
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151. What is the key to diagnosis of polycythemia vera?
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a. Markedly high hematocrit in the absence of hypoxia, with a low MCV.
b. The erythropoietin level will be low. c. The white cell count and platelet count could also be elevated. |
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152. Risk with polycythemia vera?
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a. The high hematocrit can lead to thrombosis
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153. what should be done when diagnostic testing for polycythemia vera?
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a. After the CBC shows a high hematocrit, order in arterial blood gas to exclude hypoxia as a cause of erythrocytosis.
b. If the case is a CCS, ordered erythropoietin level, which should be low, hematology consultation; and nuclear red cell mass test. c. B-12 and LAP levels are elevated in Pvera. |
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154. what mutation should you test for with polycythemia vera?
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a. JAK2.
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155. Treatment of polycythemia vera?
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a. Phlebotomy is the best initial therapy
b. hydroxyurea is also used to lower the cell count. c. Daily aspirin should also be given. d. Anagrelide is used in the context of thrombocytopenia. |
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156. In what two conditions is a JAK2 to mutation found?
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1. Pvera and ET.
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157. What you order for polycythemia vera on ccs?
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a. B12 level and LAP in addition to the CBC.
b. If the question is a “single best answer” , question. These tests would not be the single “best initial” or “most accurate” tests. |
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158. What is the key feature of Essential Thrombocythemia (ET)?
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a. Markedly elevated platelet count.
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159. Presentation of essential thrombocythemia?
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a. Headache
b. visual disturbancespain in the hands referred to as erythromelalgia. |
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160. What are the most common causes of death with essential thrombocythemia?
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a. Bleeding
b. thrombosis- (more common) |
