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155 Cards in this Set

  • Front
  • Back
Rx for neuroleptic malignant syndrome
Dantrolene
Dopamine agonists (e.g. bromocriptine)
common complication of recurrent otitis media
hearing loss
Rx for DT's
long-acting benzos (e.g. chlordiazepoxide)
possible auto-antibodies a/w type 1 DM
anti insulin (IAA)
anti islet cell cytoplasm (ICA)
anti glutamic acid decarboxylase (GAD)
anti tyrosine phosphatase (IA-2)
what lab test can be used in diabetic px to assess the adequacy of glycemic control over the last 3 months
HbA1c
leading cause of death in diabetics
CV disease
why must B-blockers be used with caution in diabetic pts
"masks" sympathetic sx's of hypoglycemia

decreases insulin release
what can cause hypoglycemia in a non-diabetic px
insulinoma (B-cell tumor)
exogenous insulin or sulfonylureas
alcohol
fasting
pituitary/adrenal insufficiency
what is the Somogyi effect
evening insulin dose is TOO HIGH --> HYPOGLYCEMIA

hypoglycemia --> release of catecholamines

catecholamines --> high glucose in the mornings
what is the dawn phenomenon
evening dose is TOO LOW --> diminishing insulin

diminishing insulin --> rising glucose (thru the night)

rising glucose --> high glucose in the mornings
Rx other than stimulants for ADHD
TCA's (e.g. Imipramine, desipramine, & nortriptyline)

bupropion

a2-agonists (e.g. clonidine)
3 reasons for involuntary psychiatric hospitalization
danger to self

danger to others

gravely disabled (e.g. catatonic schizophrenic)
what psychiatric condition occurs when a person travels a long distance and take a new name and has no memore or previous life
dissociative fugue
what are the DM'c drug classes
Sulfonylureas

Thiazolidinediones (TZD's)

Biguanides

Incretin mimetics

DPP-IV inhibitors

a-glucosidase inhibitors

Meglitinides
examples of med's within drug class:
Sulfonylureas
Glyburide

Glimeperide

Glipizide
examples of med's within drug class:
Thiazolidinediones (TZD's)
Pioglitazone

Rosiglitazone
examples of med's within drug class:
Biguanides
Metformin
examples of med's within drug class:
Incretin mimetics
Exenatide

Liraglutide
examples of med's within drug class:
DPP-IV inhibitors
Sitagliptin

Saxagliptin

Linagliptin
examples of med's within drug class:
a-glucosidase inhibitors
Acarbose
examples of med's within drug class:
Meglitinides
Repaglinide

Nateglinide
what skin finding is a sign of insulin resistance
acanthosis nigricans

(NOTE: acanthosis nigricans is also a/w occult malignancies)
diabetic Rx a/w:
lactic acidosis
metformin (rare, but worrisome SE)
diabetic Rx a/w:
MC SE is hypoglycemia
sulfonylureas

metglitinides
diabetic Rx a/w:
oldest and cheapest oral agent
sulfonylureas
diabetic Rx a/w:
often used in combination with otehr oral agents
metformin
diabetic Rx a/w:
lowers TG and LDL
metformin
diabetic Rx a/w:
not safe in HF
CHF:
pioglitazone (TZD)
rosiglitazone (TZD)

INCR'D RISK OF MI:
rosiglitazone (TZD)
diabetic Rx a/w:
should not be used in px with increased Cr
metformin

sulfonylureas
diabetic Rx a/w:
avoid in px with inflammatory bowel disease
a-glucosidase inhibitors (e.g. acarbose)
diabetic Rx a/w:
hepatic serum transaminase levels should be carefully monitored
TZD's (glitazones)

metformin

sulfonylureas
diabetic Rx a/w:
no weight gain
metformin

incretin mimetics (h/w cannot be given PO)
diabetic Rx a/w:
metabolized by liver, good choice for those with renal failure
TZD's (glitazones)
diabetic Rx a/w:
postprandial hyperglycemia
a-glucosidase inhibitors (acarbose)
what does GLP-1 do
decreases glucagon

increases insulin

delays gastric emptying
what diabetic Rx increases GLP-1
INCRETIN MIMETICS:
exenatide
liraglutide
what does DPP-4 do
Inhibit GLP-1
what diabetic Rx inhibits DPP-4, indirectly increasing GLP-1 (i.e. inhibiting an "inhibitor)
DPP-IV Inhibitors = "--gliptins"
(e.g. Sitagliptin, Saxagliptin, Linagliptin)
what diabetic Rx is an Amylin analog
pramlintide
what diabetic Rx can be used for both type 1 and type 2 DM
pramlintide
how can you Dx metabolic syndrome
Any 3 of the following

ABDOMINAL OBESITY (waist circ.): M > 40; F > 35

PRE-HTN: > 130/85

HYPERGLYCEMIA:
FBSG > 100 (or 2hr post PO glucose > 140)

DYSLIPIDEMIA:
TG's > 150
HDL: M < 40; F < 50
what diabetic drug should be stopped before performing imaging with IV contrast
METFORMIN:
d/c for 24 hrs prior to CT with contrast
re-evaluate renal fxn before re-starting
restart 48 hrs after procedure (if renal fxn is back to baseline)
diabetic drug with MOA:
decreases GI absorption or starch and disaccharides
a-glucosidase inhibitor (e.g. acarbose)
diabetic drug with MOA:
stimulates insulin release
sulfonylureas
meglitinides
diabetic drug with MOA:
decreases hepatic gluconeogenesis
metformin
TZD's (glitazones)
diabetic drug with MOA:
increases tissue glucose uptake and improves insulin sensitivity
TZD's (glitazones)
diabetic drug with MOA:
mimics action of GLP-1
INCRETIN MIMETICS:
exenatide
liraglutide
diabetic drug with MOA:
inhibits DPP-4
DDP-4 INHIBITORS = "--gliptins"
(e.g. Sitagliptin, Saxagliptin, Linagliptin)
Which type of insulin is used in continuous infusion insulin pumps & in treatment of DKA
regular Insulin (used most commonly)

very rapid-acting (e.g. Lispro, Aspart, Glulisine)
What must be kept in mind for a Type I DM'c pt that plans to begin a strenuous exercise program
Blood sugar is likely to drop during exercise as muscles take up more glucose

Pts's should always have a readily available source of glucose

Pt's should check glucose levels regularly:
before exercising
every hour during exercise
after exercising
definitive tx for subdural and epidural hematoma
evacuation with burrhole
medication used to Dx symptomatic myasthenia gravis
edrophonium (i.e. tensilon test)
MCC of seizures in children 2-10 yo
febrile
infection
trauma
ideopathic
signs and symptoms of DKA
metabolic acididosis
vomiting (WITHOUT DIARRHEA)
kussmal breathing
fruity odor on breath
polyuria/polydipsia
mental status change
Mgmt of DKA
Admit to ICU
IVF's
insulin (until anion gap closes)
glucose (if BG drops before AG closes)
Correct electrolytes (give KCl)
Tx underlying d/o
what 2 tests can be used to confirm DKA
ABG's
urine ketone
how to Dx diabetic gastroparesis
gastric emptying study
Rx for diabetic gastroparesis
DOC = metoclopramide (reglan)
2nd line = erythromycin
Rx for proliferative diabetic retinopathy
laser photocoagulation

+ glucose control
Rx for diabetic peripheral neuropathy
gabapentin
pregabalin
duloxetine

+ glucose control
anti-HTN've that will reduce proteinuria and slow/prevent diabetic nephropathy
ACEIs/ARBs
what eye problems are diabetics at increased risk for developing
cataracts

glaucoma

retinal detachement
What is the equation for anion gap
AG = [Na+] - ([Cl-] + [HCO3-])
w/u for underlying cause of DKA
R/O INFECTION:
blood/urine cultures
CXR
UA & toxicology screen

R/O PANCREATITIS:
amylase
lipase

R/O MI (in pt's > 35-40 y/o):
EKG
troponins x3
Rx for tourettes
fluphenazine (high-potency neuroleptic)

pimozide

tetrabenazine
Dx
muscle rigidity, fever and rhabdomyolysis in schizophrenic px
neuroleptic malignant syndrome
antidiabetic agent a.w lactic acidosis
metformin
Mgmt of thyroid storm
NON-PHARM:
ICU admission (25-50% mortality)
r/o infection (blood/urine cultures)
aggressive hydration (except overt HF)

PHARMACOLOGICAL:
B-blockers (to control adrenergic stimulation)
PTU/methimazole (block new hormone SYNTHESIS)
Iodine (to block T4/T3 RELEASE from gland)
Glucocorticoids (to reduce T4 --> T3 CONVERSION)
what Rx should be avoided in a pt with thyroid storm
aspirin
(interferes with thyroid protein binding, generating MORE free thyroid)
Rx with MOA:
decrease TH synthesis
PTU

methimazole
Rx with MOA:
decreases release of T4 & T3 from the gland
Iodine
Rx with MOA:
decreases T4 conversion
PTU

glucocorticoids
what thyroid abnormalities would you expect to find during pregnancy
incr'd TBG --> incr'd total T3 & T4

normal free T3 & free T4
Dx
px with exophthalmos
graves
Rx for graves
PHARMACOLOGICAL:
Methimazole or PTU

DEFINITIVE TX'S:
radioactive iodine/ablation
subtotal thyroidectomy
which thyroid dysfunction will radioactive iodine most likely result in hypothyroidism
GRAVE'S DISEASE:
radioactive iodine is taken up by fxn'l tissue
& in Grave's, the entire gland is hyperfxn'l

NOTE: likely to happen in many thyroid d/o's tx'd with radioactive iodine, but Grave's is most likely b/c hyperfxn'l thyroid
what is the FIRST step in a pt with a palpable thyroid nodule
Check TSH, FT4
Thyroid US (to measure size and assess for other nodules)
what should be done in a pt with a palpable thyroid nodule who's labs reveal hyperthyroid
radionucleotide uptake scan
what should be done in a pt with a palpable thyroid nodule who's labs reveal euthyroid
FNA
what should be done in a pt with a palpable thyroid nodule who's labs reveal hypothyroid
thyroid replacement

monitor for decrease in nodule size (if nodule persists after thyroid replacement --> FNA)
what should be done in a hyperthyroid px with cold radionucleotide uptake scan
FNA
what should be done in a hyperthyroid px with hot radionucleotide uptake scan
tx as hyperthyroidism
(i.e. B-blocker, PTU/Methimazole, Iodide, Glucocorticoids)
what should be done if a FNA of thyroid nodule is malignant
surgery
what should be done if FNA of thyroid nodule is benign
repeat US every 6 months

if increase in size --> repeat FNA
what should be done if FNA of thyroid nodule is intermediate
repeat US every 6 months

if increase in size --> repeat FNA
what should be done if FNA of thyroid nodule is nondiagnostic
repeat FNA
what lab abnormalities necessitate obtaining a thyroid function test to rule out thyroid disease
hyperlipidemia
(hypothyroid incr's LDL & total ch'ol)

hyponatremia

elevated CPK
hyperthyroidism a/w:
tender thyroid
Subacute thyroiditis (aka De Quervain Thyroiditis)
hyperthyroidism a/w:
pretibial myxedema
graves
hyperthyroidism a/w:
pride in recent weight loss
exogenous abuse
hyperthyroidism a/w:
palpation of single thyroid nodule
toxic thyroid adenoma (aka Plummer Ds)
hyperthyroidism a/w:
palpation of multiple thyroid nodules
multinodular goiter
hyperthyroidism a/w:
recent iodine IV contrast study
Jod Basedow Phenomenon
(aka iodine-induced hyperthyroidism)
hyperthyroidism a/w:
eye changes
graves
hyperthyroidism a/w:
history or thyroidectomy
excess TH replacement
lab abnormality a/w bacterial meningitis
incr'd WBCs

WITH POSSIBLE:
left shift on CBC (bandemia)
leukopenia
mild hyponatremia
RX for DKA
IVF's
IV insulin (until AG closes & NO ketones)
IV glucose (prevent hypoglycemia)
Replace electrolytes (Mg2+, Ca2+, K+, & phosphate)
disorder a/w child who has history of theft, vandalism and violence
conduct disorder
How do you tx a px who has hyperPTH who refuses or cant have surgery
ADEQUATE HYDRATION (to avoid renal stones)

MINIMIZE BONE RESORPTION:
exercise
bisphosphonates
Ca2+ (1000mg/day)
Vit D (400 - 600 IU/day)

PREVENT WORSENING HYPERCALCEMIA BY AVOIDING:
thiazide diuretics
lithium
volume depletion
prolonged bed rest
Ca2+ ingestion (>1000mg/day)

ROUTINE MONITORING:
serum Ca2+ q6 mos
serum Cr q12 mos
BMD of hip, L-spine, & forearm q12 mos
what are oral phosphate binders for px with hyperphosphatemia 2nd/2 hyperPTH
Ca2+ carbonate
Ca2+ acetate
MCC's of hyperPTH
adenoma (single PT gland)

hyperplasia (x4 PT glands)
how will vit D def affect Ca, PTH, P
decr'd Ca
incr'd PTH
decr'd P
why might PTH be increased in renal disease
renal ds --> decr'd vit D conversion --> decr'd Ca absorption (gut) --> incr'd PTH
what happens to phosphate in px with hyperPTH and renal disease
increases
likely cause of increased PTH, decreased Ca and increased P
renal failure
Ca2+, Phos, Alk phos, PTH in:
pagets
Ca2+: normal

Phos: normal

Alk phos: incr'd

PTH: normal
Ca2+, Phos, Alk phos, PTH in:
osteomalacia/rickets
Ca2+: decr'd

Phos: decr'd

Alk phos: nl/incr'd

PTH: incr'd
Ca2+, Phos, Alk phos, PTH in:
chronic renal failure
Ca2+: decr'd

Phos: incr'd

Alk phos: nl/incr'd

PTH: incr'd
Ca2+, Phos, Alk phos, PTH in:
osteoporosis
Ca2+: normal

Phos: normal

Alk phos: normal

PTH: normal
Ca2+, Phos, Alk phos, PTH in:
osteopetrosis
Ca2+: normal

Phos: normal

Alk phos: normal

PTH: normal
Ca2+, Phos, Alk phos, PTH in:
primary hyperPTH
Ca2+: incr'd

Phos: decr'd

Alk phos: incr'd

PTH: incr'd
Ca2+, Phos, Alk phos, PTH in:
hypoPTH
Ca2+: decr'd

Phos: incr'd

Alk phos: normal

PTH: decr'd
Ca2+, Phos, Alk phos, PTH in:
pseudohypoPTH
Ca2+: decr'd

Phos: incr'd

Alk phos: normal

PTH: incr'd
what is the disease a/w shortened 4th and 5th digits
albrights hereditary osteodystrophy
what are the indications for surgical parathyroidectomy
SYMPTOMATIC:
bones
stones
groans
psychiatric overtones

INCR'D [Ca2+]:
> 1.0 mg/dl above upper limits of nl


DECR'D Cr Cl (reduced by 30%) --> incr'd Cr

AGE < 50 y/o

BMD:
T-score < -2.5 (at any site)
If parathyroid adenoma is found & surgery is indicated, what is removed
REMOVAL of ONLY the gland containing adenoma

BIOPSY of 1 - 3 other glands
If parathyroid hyperplasia is found & surgery is indicated, what is removed
REMOVAL of 3 & 1/2 glands

SURGICALLY "CLIP" the remaining 1/2
(or forearm autotrasplantation in cases of high recurrence e.g. Men type 1 & IIa)
what happens to phosphate in pts with hyperPTH caused by renal ds
HYPERPHOSPHATEMIA
(2nd/2 kidney's inability to excrete phosphate)
Dx
px with exophthalmos, pretibial myxedema and decreased TSH
graves
worrisome SE of ADHD Rx, Atomoxetine
incr'd suicidal ideation

hepatic injury
what are common SE or atypical antipsychotics
fewer mvmt SE's

fewer anticholinergic SE's

Wt gain --> DM/DKA (esp, Olanzapine)
Rx for prolactinoma
DOPAMINE AGONISTS:
cabergoline
bromocriptine or pergolide
Rx for female with prolactinoma > 3cm with desire to be pregnant
withhold DA agonist

transphenoidal surgery
(even if DA agonist is effective)
what are common complications of acromegaly
cardiac failure

DM

spinal cord compression

optic nerve compression

arthropathy
screening test for acromegaly
IGF-1 levels
confirmatory test for acromegaly
oral glucose suppression test
(75g glucose --> measure GH at 1hr & 2hr;
[GH] > 1ng/mL = acromegaly)
what should be done if a px tests positive for acromegaly
pituitary MRI to evaluate for mass or empty sella
(MCC of acromegaly = pituitary adenoma)
what should be done in empty sella syndrome
nothing/reassurance
Rx for acromegaly
1ST LINE = OCTREOTIDE
(somatostatin analog: inhibits GH secretion)

2ND LINE = CABERGOLINE
(DA agonist: inhibits PRL & GH secretion)

3RD LINE = PEGVISOMANT
(GH receptor antagonist)

DEFINITIVE TX: transphenoidal resection
What is typical hyperprolactinoma presentation
MALES:
incr'd PRL --> decr'd LH/FSH --> decr'd Testosterone
decr'd LH/FSH --> HYPOGONADISM
decr'd Testosterone --> FATIGUE, LOW LIBIDO

FEMALES:
incr'd PRL --> decr'd LH/FSH --> decr'd E2/Progesterone --> AMENORRHEA GALACTORRHEA
what Rx cause elevated prolactin levels
PHENOTHIAZINES:
thioridazine
prochlorperazine
promothiazine

OTHER ANTIPSYCHOTICS:
risperidone
haloperidol

METHYLDOPA

VERAPAMIL
next step in management of a px with non-drug-induced hyperprolactinemia
MRI of brain (r/o pituitary adenoma)

TSH levels (r/o hypothyroidism)
what visual field deficit is a/w prolactinoma
bitemporal hemianopsia
what is a lactotroph adenoma
prolactinoma
what is a somatotroph adenoma
growth hormone secreting adenoma
Rx for hypercalcemia
IVF's --> urinate Ca2+ out

loops (e.g. furosemide)
Dx
px with hearing loss and vertigo, examination shows a greyish white pearly lesion involving the TM
cholesteatoma
what marker is most accurate to Dx an androgen-producing tumor in a woman
DHEA-S

(NOTE: DHEA-S made ONLY by adrenals;
DHEA & testosterone made by adrenals & ovaries)
what are the elctrolyte abnormalities found in hyperaldosteronism
hypokalemia

mildly elevated Na+

metabolic alkalosis
what is the hyperaldosteronism triad
TRIAD:
HTN
hypokalemia
metabolic alkalosis
what is the most specific lab finding in making the Dx of primary hyperaldosteronism
HIGH PAC:PRC Ratio

PAC is inc

PRC is dec

(NOTE:
PAC = plasma aldosterone concentration
PRC = plasma renin concentration)
what steroid is used to replace aldosterone
fludracortisone (100 x stronger than aldosterone)
what steroid is most like cortisol
Hydrocodone
(has glucocorticoid & mineralcorticoid action)
What is the MC pituitary tumor & what is the rx
MC = Prolactinoma

Tx = bromocriptine, cabergoline, or pergolide
Dx:
16 y/o with left arm paralysis (no medical cause is found) after her boyfriend dies in a MVA
Conversion d/o
What effect would giving a B-Blocker have on a pt with HTN due to pheochromacytoma
Worsen HTN due to unopposed a1-activity
What is the likely condition of a female infant with virilization of the genitalia & hypotension
21a-hydroxylase def --> CAH
What serum lab abnormalities would you see in 17a-hydroxylase deficiency & in 21a-hydroxylase deficiency
17a-HYDROXYLASE DEFICIENCY:
hypokalemia
mild hypernatremia
+ HTN


21a-HYDROXYLASE DEFICIENCY:
hyperkalemia
hyponatremia
+ hypotension
Dx:
A pt with acromegaly is found to have elevated Ca2+ on a blood draw during a w/u of his peptic ulcer
DX: MEN I ("3 P's"):
acromegaly = pituitary d/o
elevated Ca2+ = hyperparathyroidism
peptic ulcer = gastrin-secreting tumor (ZES)
What is involved in MEN I Syndrome
Mnemonic: "3 P's"

parathyroid hyperplasia
pituitary
pancrease (islet) or GI
What is involved in MEN IIa Syndrome
Mnemonic: "1M + 2 P's"

medullary thyroid carcinoma
parathyroid hyperplasia
pheochromacytoma
What is involved in MEN IIb Syndrome
Mnemonic: "2 M's + 1P"

medullary thyroid carcinoma
mucosal neuromas
pheochromacytoma
What oncogene is involved with the MEN Syndromes & with which type is it associated
RET Proto-Oncogene
a/w Men IIa & Men IIb
What are the MCC's of eosinophilia
Mnemonic: "DN-AAA-CP" (D-N triple-A C-P):

Drugs
Neoplasms
Allergic causes (allergies, asthma, Churg-Strauss)
Addison's Ds
Acute Interstitial Nephritis
CVD's
Parasitic Infections (including Loeffler's Eosinophilic Pneumonitis 2nd/2 Ascaris Lumbricoides)
causes of secondary HTN
pheochromacytoma
hyperaldosteronism
excess glucocorticoids
cushing's syndrome
renal artery stenosis
CAH (11a-OH & 17a-OH def's)
CKD
OCP
coarctation of aorta