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155 Cards in this Set
- Front
- Back
Rx for neuroleptic malignant syndrome
|
Dantrolene
Dopamine agonists (e.g. bromocriptine) |
|
common complication of recurrent otitis media
|
hearing loss
|
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Rx for DT's
|
long-acting benzos (e.g. chlordiazepoxide)
|
|
possible auto-antibodies a/w type 1 DM
|
anti insulin (IAA)
anti islet cell cytoplasm (ICA) anti glutamic acid decarboxylase (GAD) anti tyrosine phosphatase (IA-2) |
|
what lab test can be used in diabetic px to assess the adequacy of glycemic control over the last 3 months
|
HbA1c
|
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leading cause of death in diabetics
|
CV disease
|
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why must B-blockers be used with caution in diabetic pts
|
"masks" sympathetic sx's of hypoglycemia
decreases insulin release |
|
what can cause hypoglycemia in a non-diabetic px
|
insulinoma (B-cell tumor)
exogenous insulin or sulfonylureas alcohol fasting pituitary/adrenal insufficiency |
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what is the Somogyi effect
|
evening insulin dose is TOO HIGH --> HYPOGLYCEMIA
hypoglycemia --> release of catecholamines catecholamines --> high glucose in the mornings |
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what is the dawn phenomenon
|
evening dose is TOO LOW --> diminishing insulin
diminishing insulin --> rising glucose (thru the night) rising glucose --> high glucose in the mornings |
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Rx other than stimulants for ADHD
|
TCA's (e.g. Imipramine, desipramine, & nortriptyline)
bupropion a2-agonists (e.g. clonidine) |
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3 reasons for involuntary psychiatric hospitalization
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danger to self
danger to others gravely disabled (e.g. catatonic schizophrenic) |
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what psychiatric condition occurs when a person travels a long distance and take a new name and has no memore or previous life
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dissociative fugue
|
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what are the DM'c drug classes
|
Sulfonylureas
Thiazolidinediones (TZD's) Biguanides Incretin mimetics DPP-IV inhibitors a-glucosidase inhibitors Meglitinides |
|
examples of med's within drug class:
Sulfonylureas |
Glyburide
Glimeperide Glipizide |
|
examples of med's within drug class:
Thiazolidinediones (TZD's) |
Pioglitazone
Rosiglitazone |
|
examples of med's within drug class:
Biguanides |
Metformin
|
|
examples of med's within drug class:
Incretin mimetics |
Exenatide
Liraglutide |
|
examples of med's within drug class:
DPP-IV inhibitors |
Sitagliptin
Saxagliptin Linagliptin |
|
examples of med's within drug class:
a-glucosidase inhibitors |
Acarbose
|
|
examples of med's within drug class:
Meglitinides |
Repaglinide
Nateglinide |
|
what skin finding is a sign of insulin resistance
|
acanthosis nigricans
(NOTE: acanthosis nigricans is also a/w occult malignancies) |
|
diabetic Rx a/w:
lactic acidosis |
metformin (rare, but worrisome SE)
|
|
diabetic Rx a/w:
MC SE is hypoglycemia |
sulfonylureas
metglitinides |
|
diabetic Rx a/w:
oldest and cheapest oral agent |
sulfonylureas
|
|
diabetic Rx a/w:
often used in combination with otehr oral agents |
metformin
|
|
diabetic Rx a/w:
lowers TG and LDL |
metformin
|
|
diabetic Rx a/w:
not safe in HF |
CHF:
pioglitazone (TZD) rosiglitazone (TZD) INCR'D RISK OF MI: rosiglitazone (TZD) |
|
diabetic Rx a/w:
should not be used in px with increased Cr |
metformin
sulfonylureas |
|
diabetic Rx a/w:
avoid in px with inflammatory bowel disease |
a-glucosidase inhibitors (e.g. acarbose)
|
|
diabetic Rx a/w:
hepatic serum transaminase levels should be carefully monitored |
TZD's (glitazones)
metformin sulfonylureas |
|
diabetic Rx a/w:
no weight gain |
metformin
incretin mimetics (h/w cannot be given PO) |
|
diabetic Rx a/w:
metabolized by liver, good choice for those with renal failure |
TZD's (glitazones)
|
|
diabetic Rx a/w:
postprandial hyperglycemia |
a-glucosidase inhibitors (acarbose)
|
|
what does GLP-1 do
|
decreases glucagon
increases insulin delays gastric emptying |
|
what diabetic Rx increases GLP-1
|
INCRETIN MIMETICS:
exenatide liraglutide |
|
what does DPP-4 do
|
Inhibit GLP-1
|
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what diabetic Rx inhibits DPP-4, indirectly increasing GLP-1 (i.e. inhibiting an "inhibitor)
|
DPP-IV Inhibitors = "--gliptins"
(e.g. Sitagliptin, Saxagliptin, Linagliptin) |
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what diabetic Rx is an Amylin analog
|
pramlintide
|
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what diabetic Rx can be used for both type 1 and type 2 DM
|
pramlintide
|
|
how can you Dx metabolic syndrome
|
Any 3 of the following
ABDOMINAL OBESITY (waist circ.): M > 40; F > 35 PRE-HTN: > 130/85 HYPERGLYCEMIA: FBSG > 100 (or 2hr post PO glucose > 140) DYSLIPIDEMIA: TG's > 150 HDL: M < 40; F < 50 |
|
what diabetic drug should be stopped before performing imaging with IV contrast
|
METFORMIN:
d/c for 24 hrs prior to CT with contrast re-evaluate renal fxn before re-starting restart 48 hrs after procedure (if renal fxn is back to baseline) |
|
diabetic drug with MOA:
decreases GI absorption or starch and disaccharides |
a-glucosidase inhibitor (e.g. acarbose)
|
|
diabetic drug with MOA:
stimulates insulin release |
sulfonylureas
meglitinides |
|
diabetic drug with MOA:
decreases hepatic gluconeogenesis |
metformin
TZD's (glitazones) |
|
diabetic drug with MOA:
increases tissue glucose uptake and improves insulin sensitivity |
TZD's (glitazones)
|
|
diabetic drug with MOA:
mimics action of GLP-1 |
INCRETIN MIMETICS:
exenatide liraglutide |
|
diabetic drug with MOA:
inhibits DPP-4 |
DDP-4 INHIBITORS = "--gliptins"
(e.g. Sitagliptin, Saxagliptin, Linagliptin) |
|
Which type of insulin is used in continuous infusion insulin pumps & in treatment of DKA
|
regular Insulin (used most commonly)
very rapid-acting (e.g. Lispro, Aspart, Glulisine) |
|
What must be kept in mind for a Type I DM'c pt that plans to begin a strenuous exercise program
|
Blood sugar is likely to drop during exercise as muscles take up more glucose
Pts's should always have a readily available source of glucose Pt's should check glucose levels regularly: before exercising every hour during exercise after exercising |
|
definitive tx for subdural and epidural hematoma
|
evacuation with burrhole
|
|
medication used to Dx symptomatic myasthenia gravis
|
edrophonium (i.e. tensilon test)
|
|
MCC of seizures in children 2-10 yo
|
febrile
infection trauma ideopathic |
|
signs and symptoms of DKA
|
metabolic acididosis
vomiting (WITHOUT DIARRHEA) kussmal breathing fruity odor on breath polyuria/polydipsia mental status change |
|
Mgmt of DKA
|
Admit to ICU
IVF's insulin (until anion gap closes) glucose (if BG drops before AG closes) Correct electrolytes (give KCl) Tx underlying d/o |
|
what 2 tests can be used to confirm DKA
|
ABG's
urine ketone |
|
how to Dx diabetic gastroparesis
|
gastric emptying study
|
|
Rx for diabetic gastroparesis
|
DOC = metoclopramide (reglan)
2nd line = erythromycin |
|
Rx for proliferative diabetic retinopathy
|
laser photocoagulation
+ glucose control |
|
Rx for diabetic peripheral neuropathy
|
gabapentin
pregabalin duloxetine + glucose control |
|
anti-HTN've that will reduce proteinuria and slow/prevent diabetic nephropathy
|
ACEIs/ARBs
|
|
what eye problems are diabetics at increased risk for developing
|
cataracts
glaucoma retinal detachement |
|
What is the equation for anion gap
|
AG = [Na+] - ([Cl-] + [HCO3-])
|
|
w/u for underlying cause of DKA
|
R/O INFECTION:
blood/urine cultures CXR UA & toxicology screen R/O PANCREATITIS: amylase lipase R/O MI (in pt's > 35-40 y/o): EKG troponins x3 |
|
Rx for tourettes
|
fluphenazine (high-potency neuroleptic)
pimozide tetrabenazine |
|
Dx
muscle rigidity, fever and rhabdomyolysis in schizophrenic px |
neuroleptic malignant syndrome
|
|
antidiabetic agent a.w lactic acidosis
|
metformin
|
|
Mgmt of thyroid storm
|
NON-PHARM:
ICU admission (25-50% mortality) r/o infection (blood/urine cultures) aggressive hydration (except overt HF) PHARMACOLOGICAL: B-blockers (to control adrenergic stimulation) PTU/methimazole (block new hormone SYNTHESIS) Iodine (to block T4/T3 RELEASE from gland) Glucocorticoids (to reduce T4 --> T3 CONVERSION) |
|
what Rx should be avoided in a pt with thyroid storm
|
aspirin
(interferes with thyroid protein binding, generating MORE free thyroid) |
|
Rx with MOA:
decrease TH synthesis |
PTU
methimazole |
|
Rx with MOA:
decreases release of T4 & T3 from the gland |
Iodine
|
|
Rx with MOA:
decreases T4 conversion |
PTU
glucocorticoids |
|
what thyroid abnormalities would you expect to find during pregnancy
|
incr'd TBG --> incr'd total T3 & T4
normal free T3 & free T4 |
|
Dx
px with exophthalmos |
graves
|
|
Rx for graves
|
PHARMACOLOGICAL:
Methimazole or PTU DEFINITIVE TX'S: radioactive iodine/ablation subtotal thyroidectomy |
|
which thyroid dysfunction will radioactive iodine most likely result in hypothyroidism
|
GRAVE'S DISEASE:
radioactive iodine is taken up by fxn'l tissue & in Grave's, the entire gland is hyperfxn'l NOTE: likely to happen in many thyroid d/o's tx'd with radioactive iodine, but Grave's is most likely b/c hyperfxn'l thyroid |
|
what is the FIRST step in a pt with a palpable thyroid nodule
|
Check TSH, FT4
Thyroid US (to measure size and assess for other nodules) |
|
what should be done in a pt with a palpable thyroid nodule who's labs reveal hyperthyroid
|
radionucleotide uptake scan
|
|
what should be done in a pt with a palpable thyroid nodule who's labs reveal euthyroid
|
FNA
|
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what should be done in a pt with a palpable thyroid nodule who's labs reveal hypothyroid
|
thyroid replacement
monitor for decrease in nodule size (if nodule persists after thyroid replacement --> FNA) |
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what should be done in a hyperthyroid px with cold radionucleotide uptake scan
|
FNA
|
|
what should be done in a hyperthyroid px with hot radionucleotide uptake scan
|
tx as hyperthyroidism
(i.e. B-blocker, PTU/Methimazole, Iodide, Glucocorticoids) |
|
what should be done if a FNA of thyroid nodule is malignant
|
surgery
|
|
what should be done if FNA of thyroid nodule is benign
|
repeat US every 6 months
if increase in size --> repeat FNA |
|
what should be done if FNA of thyroid nodule is intermediate
|
repeat US every 6 months
if increase in size --> repeat FNA |
|
what should be done if FNA of thyroid nodule is nondiagnostic
|
repeat FNA
|
|
what lab abnormalities necessitate obtaining a thyroid function test to rule out thyroid disease
|
hyperlipidemia
(hypothyroid incr's LDL & total ch'ol) hyponatremia elevated CPK |
|
hyperthyroidism a/w:
tender thyroid |
Subacute thyroiditis (aka De Quervain Thyroiditis)
|
|
hyperthyroidism a/w:
pretibial myxedema |
graves
|
|
hyperthyroidism a/w:
pride in recent weight loss |
exogenous abuse
|
|
hyperthyroidism a/w:
palpation of single thyroid nodule |
toxic thyroid adenoma (aka Plummer Ds)
|
|
hyperthyroidism a/w:
palpation of multiple thyroid nodules |
multinodular goiter
|
|
hyperthyroidism a/w:
recent iodine IV contrast study |
Jod Basedow Phenomenon
(aka iodine-induced hyperthyroidism) |
|
hyperthyroidism a/w:
eye changes |
graves
|
|
hyperthyroidism a/w:
history or thyroidectomy |
excess TH replacement
|
|
lab abnormality a/w bacterial meningitis
|
incr'd WBCs
WITH POSSIBLE: left shift on CBC (bandemia) leukopenia mild hyponatremia |
|
RX for DKA
|
IVF's
IV insulin (until AG closes & NO ketones) IV glucose (prevent hypoglycemia) Replace electrolytes (Mg2+, Ca2+, K+, & phosphate) |
|
disorder a/w child who has history of theft, vandalism and violence
|
conduct disorder
|
|
How do you tx a px who has hyperPTH who refuses or cant have surgery
|
ADEQUATE HYDRATION (to avoid renal stones)
MINIMIZE BONE RESORPTION: exercise bisphosphonates Ca2+ (1000mg/day) Vit D (400 - 600 IU/day) PREVENT WORSENING HYPERCALCEMIA BY AVOIDING: thiazide diuretics lithium volume depletion prolonged bed rest Ca2+ ingestion (>1000mg/day) ROUTINE MONITORING: serum Ca2+ q6 mos serum Cr q12 mos BMD of hip, L-spine, & forearm q12 mos |
|
what are oral phosphate binders for px with hyperphosphatemia 2nd/2 hyperPTH
|
Ca2+ carbonate
Ca2+ acetate |
|
MCC's of hyperPTH
|
adenoma (single PT gland)
hyperplasia (x4 PT glands) |
|
how will vit D def affect Ca, PTH, P
|
decr'd Ca
incr'd PTH decr'd P |
|
why might PTH be increased in renal disease
|
renal ds --> decr'd vit D conversion --> decr'd Ca absorption (gut) --> incr'd PTH
|
|
what happens to phosphate in px with hyperPTH and renal disease
|
increases
|
|
likely cause of increased PTH, decreased Ca and increased P
|
renal failure
|
|
Ca2+, Phos, Alk phos, PTH in:
pagets |
Ca2+: normal
Phos: normal Alk phos: incr'd PTH: normal |
|
Ca2+, Phos, Alk phos, PTH in:
osteomalacia/rickets |
Ca2+: decr'd
Phos: decr'd Alk phos: nl/incr'd PTH: incr'd |
|
Ca2+, Phos, Alk phos, PTH in:
chronic renal failure |
Ca2+: decr'd
Phos: incr'd Alk phos: nl/incr'd PTH: incr'd |
|
Ca2+, Phos, Alk phos, PTH in:
osteoporosis |
Ca2+: normal
Phos: normal Alk phos: normal PTH: normal |
|
Ca2+, Phos, Alk phos, PTH in:
osteopetrosis |
Ca2+: normal
Phos: normal Alk phos: normal PTH: normal |
|
Ca2+, Phos, Alk phos, PTH in:
primary hyperPTH |
Ca2+: incr'd
Phos: decr'd Alk phos: incr'd PTH: incr'd |
|
Ca2+, Phos, Alk phos, PTH in:
hypoPTH |
Ca2+: decr'd
Phos: incr'd Alk phos: normal PTH: decr'd |
|
Ca2+, Phos, Alk phos, PTH in:
pseudohypoPTH |
Ca2+: decr'd
Phos: incr'd Alk phos: normal PTH: incr'd |
|
what is the disease a/w shortened 4th and 5th digits
|
albrights hereditary osteodystrophy
|
|
what are the indications for surgical parathyroidectomy
|
SYMPTOMATIC:
bones stones groans psychiatric overtones INCR'D [Ca2+]: > 1.0 mg/dl above upper limits of nl DECR'D Cr Cl (reduced by 30%) --> incr'd Cr AGE < 50 y/o BMD: T-score < -2.5 (at any site) |
|
If parathyroid adenoma is found & surgery is indicated, what is removed
|
REMOVAL of ONLY the gland containing adenoma
BIOPSY of 1 - 3 other glands |
|
If parathyroid hyperplasia is found & surgery is indicated, what is removed
|
REMOVAL of 3 & 1/2 glands
SURGICALLY "CLIP" the remaining 1/2 (or forearm autotrasplantation in cases of high recurrence e.g. Men type 1 & IIa) |
|
what happens to phosphate in pts with hyperPTH caused by renal ds
|
HYPERPHOSPHATEMIA
(2nd/2 kidney's inability to excrete phosphate) |
|
Dx
px with exophthalmos, pretibial myxedema and decreased TSH |
graves
|
|
worrisome SE of ADHD Rx, Atomoxetine
|
incr'd suicidal ideation
hepatic injury |
|
what are common SE or atypical antipsychotics
|
fewer mvmt SE's
fewer anticholinergic SE's Wt gain --> DM/DKA (esp, Olanzapine) |
|
Rx for prolactinoma
|
DOPAMINE AGONISTS:
cabergoline bromocriptine or pergolide |
|
Rx for female with prolactinoma > 3cm with desire to be pregnant
|
withhold DA agonist
transphenoidal surgery (even if DA agonist is effective) |
|
what are common complications of acromegaly
|
cardiac failure
DM spinal cord compression optic nerve compression arthropathy |
|
screening test for acromegaly
|
IGF-1 levels
|
|
confirmatory test for acromegaly
|
oral glucose suppression test
(75g glucose --> measure GH at 1hr & 2hr; [GH] > 1ng/mL = acromegaly) |
|
what should be done if a px tests positive for acromegaly
|
pituitary MRI to evaluate for mass or empty sella
(MCC of acromegaly = pituitary adenoma) |
|
what should be done in empty sella syndrome
|
nothing/reassurance
|
|
Rx for acromegaly
|
1ST LINE = OCTREOTIDE
(somatostatin analog: inhibits GH secretion) 2ND LINE = CABERGOLINE (DA agonist: inhibits PRL & GH secretion) 3RD LINE = PEGVISOMANT (GH receptor antagonist) DEFINITIVE TX: transphenoidal resection |
|
What is typical hyperprolactinoma presentation
|
MALES:
incr'd PRL --> decr'd LH/FSH --> decr'd Testosterone decr'd LH/FSH --> HYPOGONADISM decr'd Testosterone --> FATIGUE, LOW LIBIDO FEMALES: incr'd PRL --> decr'd LH/FSH --> decr'd E2/Progesterone --> AMENORRHEA GALACTORRHEA |
|
what Rx cause elevated prolactin levels
|
PHENOTHIAZINES:
thioridazine prochlorperazine promothiazine OTHER ANTIPSYCHOTICS: risperidone haloperidol METHYLDOPA VERAPAMIL |
|
next step in management of a px with non-drug-induced hyperprolactinemia
|
MRI of brain (r/o pituitary adenoma)
TSH levels (r/o hypothyroidism) |
|
what visual field deficit is a/w prolactinoma
|
bitemporal hemianopsia
|
|
what is a lactotroph adenoma
|
prolactinoma
|
|
what is a somatotroph adenoma
|
growth hormone secreting adenoma
|
|
Rx for hypercalcemia
|
IVF's --> urinate Ca2+ out
loops (e.g. furosemide) |
|
Dx
px with hearing loss and vertigo, examination shows a greyish white pearly lesion involving the TM |
cholesteatoma
|
|
what marker is most accurate to Dx an androgen-producing tumor in a woman
|
DHEA-S
(NOTE: DHEA-S made ONLY by adrenals; DHEA & testosterone made by adrenals & ovaries) |
|
what are the elctrolyte abnormalities found in hyperaldosteronism
|
hypokalemia
mildly elevated Na+ metabolic alkalosis |
|
what is the hyperaldosteronism triad
|
TRIAD:
HTN hypokalemia metabolic alkalosis |
|
what is the most specific lab finding in making the Dx of primary hyperaldosteronism
|
HIGH PAC:PRC Ratio
PAC is inc PRC is dec (NOTE: PAC = plasma aldosterone concentration PRC = plasma renin concentration) |
|
what steroid is used to replace aldosterone
|
fludracortisone (100 x stronger than aldosterone)
|
|
what steroid is most like cortisol
|
Hydrocodone
(has glucocorticoid & mineralcorticoid action) |
|
What is the MC pituitary tumor & what is the rx
|
MC = Prolactinoma
Tx = bromocriptine, cabergoline, or pergolide |
|
Dx:
16 y/o with left arm paralysis (no medical cause is found) after her boyfriend dies in a MVA |
Conversion d/o
|
|
What effect would giving a B-Blocker have on a pt with HTN due to pheochromacytoma
|
Worsen HTN due to unopposed a1-activity
|
|
What is the likely condition of a female infant with virilization of the genitalia & hypotension
|
21a-hydroxylase def --> CAH
|
|
What serum lab abnormalities would you see in 17a-hydroxylase deficiency & in 21a-hydroxylase deficiency
|
17a-HYDROXYLASE DEFICIENCY:
hypokalemia mild hypernatremia + HTN 21a-HYDROXYLASE DEFICIENCY: hyperkalemia hyponatremia + hypotension |
|
Dx:
A pt with acromegaly is found to have elevated Ca2+ on a blood draw during a w/u of his peptic ulcer |
DX: MEN I ("3 P's"):
acromegaly = pituitary d/o elevated Ca2+ = hyperparathyroidism peptic ulcer = gastrin-secreting tumor (ZES) |
|
What is involved in MEN I Syndrome
|
Mnemonic: "3 P's"
parathyroid hyperplasia pituitary pancrease (islet) or GI |
|
What is involved in MEN IIa Syndrome
|
Mnemonic: "1M + 2 P's"
medullary thyroid carcinoma parathyroid hyperplasia pheochromacytoma |
|
What is involved in MEN IIb Syndrome
|
Mnemonic: "2 M's + 1P"
medullary thyroid carcinoma mucosal neuromas pheochromacytoma |
|
What oncogene is involved with the MEN Syndromes & with which type is it associated
|
RET Proto-Oncogene
a/w Men IIa & Men IIb |
|
What are the MCC's of eosinophilia
|
Mnemonic: "DN-AAA-CP" (D-N triple-A C-P):
Drugs Neoplasms Allergic causes (allergies, asthma, Churg-Strauss) Addison's Ds Acute Interstitial Nephritis CVD's Parasitic Infections (including Loeffler's Eosinophilic Pneumonitis 2nd/2 Ascaris Lumbricoides) |
|
causes of secondary HTN
|
pheochromacytoma
hyperaldosteronism excess glucocorticoids cushing's syndrome renal artery stenosis CAH (11a-OH & 17a-OH def's) CKD OCP coarctation of aorta |