Step 2 Derm

Front 1

Dry gangrene:
MCC?
Tx?
RF?

Back 1

MC due to insufficient blood flow secondary to atherosclerosis
-Important to reestablish blood flow
-Risk factors: diabetes, vasculopathy, smoking

Front 2

Hypersensitivity type 1:

Back 2

IgE mediated, causing release of histamine from mast cells, happens immediately
•Anaphylaxis, asthma, angioedema, urticarial

Front 3

Hypersensitivity type 2:

Back 3

cytoxic (IgM and IgG binding to antigen causing lysis or phagocytosis)
•Rh, AI hemolytic anemia, goodpastures, rheumatic fever, graves, myasthenia gravis

Front 4

Hypersensitivity type 3:

Back 4

immune complex mediated that activates neutrophils, releasing lysosomal enzymes
•Polyarterosis nodosa, SLE, RA, post-streptococcal glomerulonephritis

Front 5

Hypersensitivity type 4:

Back 5

contact dermatitis, cell-mediated delayed
•Two phases: sensitization, elicitation, takes 12-48 hours of exposure

Front 6

Necrotizing Fasciitis:
MCC?
Tx?
Radiologic Finding?

Back 6

MC Group A Strep, IV abx needed immediately w/ surgical debridement
-Sub Q air is a classic radiograph finding

Front 7

Molluscum contagiosum:
cause?
histo finding?
tx?

Back 7

poxvirus, can be STD,
-henderson-paterson inclusion bodies on histo
-Can be left alone or I&D

Front 8

Difference b/t atopic derm and fifths disease (erythema infectiosum):

Back 8

atopic dermatitis will have increased IgE and eosinophilia

Front 9

Lichen Planus:
presentation?

Back 9

middle aged, pruritic, popular rash w/ violaceous color and sometimes scales
-5 P’s: “Pruritic purple polyglonal papules and plaques”

Front 10

Pityriasis rosea: presentation

Back 10

“christmas tree” oval shaped rash, preceded by a single large lesion w/ a cleared center

Front 11

Vitaligo:
Cause?

Back 11

AI disease, associated w/ other AI diseases (PA, hoshimotos)

Front 12

KOH positive scrapings indicate?

Back 12

fungal origin, usually Tinea versicolor

Front 13

Tinea Versicolor Tx?

Back 13

-Tinea versicolor Tx w/ ketoconazole 2%, can come and go depending on temp/humidity

Front 14

SJS:
presentation?
Causes?

Back 14

-SJS <10% body surface,
-Presents with 1-14 days URI Sx’s, fever, sore throat, cough
-SJS MC triggered by drugs, Anti-epileptics, PCN, Sulfa, macrolides and quinolones
- Negative Nikolsky sign

Front 15

Toxic Epidermal Necrolysis (TEN):
presentation?

Back 15

TEN >30% body surface
- Positive Nikolsky sign

Front 16

Bullous Pemphigoid:
Presentation:
Tx?

Back 16

AI w/ antibodies against dermo-epidural junction zone, propensity for flexor surfaces, 70-80 age, negative Nikolsky sign
-Tx w/ anti-inflammatory (prednisone)

Front 17

Pemphigus Vulgaris:
Presentation:
Tx?

Back 17

potentially life threatening, anti-epithelial antibodies, 30-40 age, + Nikolsky sign (usually)
-Tx w/ anti-inflammatory (prednisone)

Front 18

Nikolsky sign:

Back 18

slight rubbing of skin results in exfoliation of outermost layer, found in TEN and possibly in Staph scalded skin syndrome and pemphigus vulgaris

Front 19

Most important preventable risk factor of melanoma:

Back 19

chronic sun exposure, reduce mortality most with early detection

Front 20

Warfarin-induced skin necrosis

Back 20

uncommonly occur during 1st week of high doses warfarin

Front 21

Fournier gangrene:

Back 21

necrotizing soft tissue infx of male genitals and perineum

Front 22

Pale, velvety pink or white, Hypopigmented macules that do NOT tan and DO scale on scraping?
Tx?

Back 22

- Tinea Versicolor
- Tx w/ selenium sulfide cream and ketoconazole shampoo

Front 23

Symmetrical, hyperpigmented, velvety plaques in axilla, groin, and neck area?
Cause?

Back 23

- Acanthosis Nigricans
- caused by DM and sometimes GI malignancy