Step 2 Ck Drug Side Effects

Front 1

ACEIs

Back 1

COUGH, rash, proteinuria, angiodemia, taste change, teratogenic effects

Front 2

Amantadine

Back 2

Ataxia, livedo reticularis

Front 3

Aminoglycosides

Back 3

Ototoxicity, nephrotoxicity (ATN)

Front 4

Amiodarone

Back 4

Acute: AV block, hypotension, bradycardia Chronic: Pulm fibrosis, peripheral deposition leading to bluish discoloration, arrhythmias, hypo/hyperthyroidism, corneal disposition

Front 5

Amphotericin

Back 5

Fever/rigors, nephrotoxicity, bone suppression, anemia

Front 6

Antipsychotics

Back 6

Sedation, acute dystonic run, akathisia, parkinsonism, tardive dyskinesia, NMS

Front 7

Azoles (eg. fluconazole)

Back 7

Inhibition of P-450 enzymes

Front 8

AZT

Back 8

Thrombocytopenia, megaloblastic anemia

Front 9

B-Blockers

Back 9

Asthma exacerbation, masking of hypoglycemia, impotence, bradycardia, AV block, CHF

Front 10

Benzos

Back 10

Sedation, dependence, respiratory depression

Front 11

Bile acid resins

Back 11

GI upset, malabsorption of vitamins and meds

Front 12

Carbamazepine

Back 12

Induction of P-450 enzymes, agranulocytosis, aplastic anemia, liver toxicity

Front 13

CCBs

Back 13

Peripheral edema, constipation, cardiac depression

Front 14

Chloramphenicol

Back 14

Gray Baby syndrome, aplastic anemia

Front 15

Cisplatin

Back 15

Nephrotoxicity, acoustic nerve damage

Front 16

Clonidine

Back 16

Dry mouth, severe rebound headache and hypertension

Front 17

Clozapine

Back 17

Agranulocytosis

Front 18

Corticosteroids

Back 18

Mania, hyperglycemia (acute), immunosuppression, bone mineral loss, thinning of skin, easy bruising, myopathy, cataracts (chronic)

Front 19

Cyclophosphamide

Back 19

Myelosuppression, hemorrhagic cystitis

Front 20

Digoxin

Back 20

GI disturbance, yellow visual changes, arrhythmias (junctional tachycardia or SVT)

Front 21

Doxorubicin

Back 21

Cardiotoxicity (cardiomyopathy)

Front 22

Ethyl EtOH

Back 22

Acidosis, renal dysfunction, CNS depression

Front 23

Fluoroquinolones

Back 23

Cartilage damage in children; Achilles tendon rupture in adults

Front 24

Furosemide

Back 24

Ototoxicity, hypokalemia, nephritis, gout

Front 25

Gemfibrozil

Back 25

Myositis, reversible INC in LFTs

Front 26

Halothane

Back 26

Hepatotoxicity, malignant hyperthermia

Front 27

HCTZ

Back 27

hypokalemia, hypoNa, hyperGlycemia, hyperUricemia, hyperCalcemia

Front 28

HMG-CoA reductase inhibitors

Back 28

Myositis, reversible INC in LFTs

Front 29

Hydralazine

Back 29

Drug-induced SLE

Front 30

Hydroxychloroquine

Back 30

Retinopathy

Front 31

INH

Back 31

Peripheral neuropathy (prevent with pyridoxine/Vit B6), hepatotoxicity, inhibition of P-450 enzymes, seizures with overdose, hemolysis in G6PD deficiency

Front 32

MAOIs

Back 32

Hypertensive tyramine rxn, serotonin syndrome (with meperidine)

Front 33

Methanol

Back 33

Blindness, ion-gap metabolic acidosis

Front 34

Methotrexate

Back 34

Hepatic fibrosis, pneumonitis, anemia

Front 35

Halothane

Back 35

Hepatotoxicity, malignant hyperthermia

Front 36

HCTZ

Back 36

hypokalemia, hypoNA, hyperGlycemia, hyperUricemia, hyperCalcemia

Front 37

HMG-CoA reductase inhibitor

Back 37

Myositis, reversible INC in LFTs

Front 38

Hydralazine

Back 38

drug-induced SLE

Front 39

Hydroxychloroquine

Back 39

Retinopathy

Front 40

INH

Back 40

Peripheral neuropathy (prevent with pyridoxine/B6), hepatotoxicity, inhibition of P-450 enzymes, seizures with OD, hemolysis in G6PD

Front 41

MAOIs

Back 41

Hypertensive tyramine rxn, serotonin syndrome (with meperidine)

Front 42

Methanol

Back 42

Blindness, ion-gap metabolic acidosis

Front 43

Methotrexate

Back 43

Hepatic fibrosis, pneumonitis, anemia

Front 44

Methyldopa

Back 44

+ Coombs test, drug-induced SLE

Front 45

Metronidazole

Back 45

Disulfiram reaction, vestibular dysfunction, metallic taste

Front 46

Niacin

Back 46

Cutaneous flushing

Front 47

Nitroglycerin

Back 47

Hypotension, tachycardia, HA, tolerance

Front 48

Penicillamine

Back 48

Drug-induced SLE

Front 49

Penicillin/beta-lactam

Back 49

Hypersensitivity rxn

Front 50

Phenytoin

Back 50

Nystagmus, diplopia, ataxia, arrhythmia (in toxic doses), gingival hyperplasia, hirsuitism, teratogenic effects

Front 51

Prazosin

Back 51

first-dose hypotension

Front 52

Procainamide

Back 52

Drug-induced SLE

Front 53

Propylthiouracil

Back 53

Agranulocytosis, aplastic anemia

Front 54

Quinidine

Back 54

Cinchoism (HA, tinnitus), thrombocytopenia, arrhythmia (torsades de pointes)

Front 55

Reserpine

Back 55

Depression

Front 56

Rifampin

Back 56

Induction of P-450 enzymes, orange-red body secretions

Front 57

Salicylates

Back 57

Fever, hyperventilation with reps alkalosis and metabolic acidosis, dehydration, diaphoresis, hemorrhagic gastritis

Front 58

Succinylcholine

Back 58

Malignant hyperthermia, hyperkalemia

Front 59

TCAs

Back 59

Sedation, coma, anticholinergic effects, seizures, QRS prolongation, arrhythmia

Front 60

Tetracycline

Back 60

Tooth discoloration, photosensitivity, Fanconi's syndrome, GI distress

Front 61

Trimethoprim

Back 61

Megaloblastic anemia, leukopenia, granulocytopenia

Front 62

Valproic acid

Back 62

Teratogenicity leads to NTDs; rare fatal hepatotoxicity

Front 63

Vancomycin

Back 63

Nephrotoxicity, ototoxicity, "red man syndrome" (histamine release, not an allergy!!!)

Front 64

Vincristine

Back 64

Peripheral neuropathy, paralytic ileus