Step 1: Pharm Iv Rxn/interactions

Front 1

P450 inducers? (mnemonic)

Inhibitors? (mnemonic)

Back 1

"Queen Barb Steals Phen-phen and Refuses Greasy Carbs Chronically"
- quinidine, barbiturates, St. John's wort, phenytoin, rifampin, griseofulvin, Carbamazepine, Chronic EtOH use

"stop doing KEG stands, they make you ACUTEly SICk"
- Ketoconazole, Erythromycin, Grapefruit juice, Acute EtOH, Sulfonamides, Isoniazid, Cimetidine.

Front 2

Cardio side effects:
- Atropine like side effects:
- Coronary vasospasm
- Cutaneous flushing:
- Dilated cardiomyopathy
- Torsades de pointes

Back 2

- TCA
- Cocaine, sumitriptan
- VANC:
+vancomycin, adenosine, Niacin, CCB's
- Doxorubicin (Adriamycin), daunorubicin
- Class III (sotalol), Class IA (quinidine); cisapride

Front 3

Hematologic:
- Agranulocytosis
- Aplastic anemia
- Direct Coombs + hemolytic anemia
- Gray baby
- Hemolysis in G6PD def (mnemonic)
- Megaloblastic anemia (mnemonic)
- Thrombotic complicatoins

Back 3

- clozapine, carbamazepine, colchicine, propylthiouracil, methimazole, dapsone
- chloramphenicol, benzene, NSAIDS, PTU, methimazole
- Methyldopa
- Chloramphenicol
- "hemolysis IS PAIN"
+ INH, sulfonamides, Primaquine, ASA, Ibuprofen, Nitrofurantoi
- "Cells are having a BLAST with PMS"
+ Phenytoin, MTX, sulfa drugs
- OCPs (estrogens and progestins)

Front 4

Respiratory side effects:
- cough
- pulmonary fibrosis (mnemonic)

Back 4

- ACE inhibitors
- "It's hard to BLAB when you can't breath (have pulmonary fibrosis"
+ Bleomycin, Amiodarone, Busulfan

Front 5

GI side effects:
- Acute cholestatic hepatitis
- Focal to massive hepatic necrosis
- Hepatitis
- Pseudomembranous colitis

Back 5

- macrolides
- halothane, balproic acid, acetaminopehn, Amanita phalloides
- INH
- clindamycin, ampicillin

Front 6

Reproductive/Endocrine side effects:
- Adrenocortical insufficiency
- Gynecomastia (mnemonic)
- Hot flashes
- Hypothyroidism

Back 6

- glucocorticoid withdrawal (HPA suppression)
- "Some Drugs Create Awesome Knockers"
+ spironolactone, Digitalis, Cimetidine, chronic Alcohol use, estrogens (of course), Ketoconazole
- Tamoxifen, clomiphene
- Lithium, amiodarone

Front 7

MSK side effects:
- Gingival hyperplasia
- Gout
- Osteoporosis
- Photosensitivity (mnemonic)
- Rash (Steven's-Johnson syndrome)
- SLE-like (mnemonic)
- Tendonitis, tendon rupture, and cartilage damage (kids)

Back 7

- phenytoin
- furosemide, thiazide
- corticosteroids, heparin
- "SAT for a photo"
+ Sulfonamides, Amiodarone, Tetracyclines
- Ethosuximide, lamotrigine, carbamazepine, phenobarbital, phenytoin, sulfa drugs, penicillin, allopurinol
- "It's not HIPP to have lupus"
+ Hydralazine, INH, Procainamide, Phenytoin
- Fluoroquinolones

Front 8

Renal/GU
- Fanconi's syndrome
- Interstitiatl nephritis
- Hemorrhagic cystitis (how prevent)

Back 8

- Expired tetracycline
- methicillin, NSAIDs, furosemide
- cyclophosphamide, ifosfamide (prevent by coadmin w/ mesna)

Front 9

Neurologic Side effects:
- Cinchronism
- Diabetes insipidis (neurogenic)
- Parkinson-like syndrome
- Seizures
- Tardive dyskinesia

Back 9

- Quinidine, quinine
- Lithium, demeclocycline
- Haloperidol, chlorpromazine, reserpine, metoclopramide
- bupropion, imipenem/cilastatin, INH (isoniazid)
- antipsychotics

Front 10

Multiorgan SE:
- Disulfram-like
- Nephrotox & neurotox
- Nephrotox & ototox

Back 10

- Metronixazole, certain cephalosporings, procarbazine, 1st gen sulfonylureas
- polymyxins
- aminoglycosides, vancomycin, loop diuretics, cisplatin

Front 11

Name sulfa drugs.
- possible side effects of allergy?

Back 11

Celecoxib, furosemide, probenacid, thiazides, TMP-SMX, sulfasalazine, sulfonylureas, sumatriptan
- fever, pruritic rash, Stevens-Johnson syndrome, Hemolytic anemia, Thrombocytopenia, agranulocytosis, and urticaris (hives)

Front 12

Disulfram inhibits what? What builds up?

What inhibits alcohol dehyrogenase? why is this good to give in ethylene glycol and methanol poisonings?

Back 12

acetaldehyde dehydrogenase. Acetaldehyde builds up --> N, V, HA, hypotension.

fomepizole
- it will stop them from being converted into their bad metabolites by the enzyme.