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14 Cards in this Set
- Front
- Back
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Tx for anaphylaxis?
Tx for premature uterine contractions? (2) - which one isn't 100% selective? |
Epi
Ritodrine (B2 agonist) or Terbutaline... Terbutaline is of the class of B2 > B1 usually used for asthma... it's not entirely selective. |
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Epi is what type of sympathomimetic?
- @ low doses? NE? Isoproterenol? - uses? |
a1, a2, B1, B2....
- can be mildly B1 selective. a1, a2 > B1 B1 = B2 - AV block of heart (rare) |
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DA is what type of sympathomimetic?
Dobutamine? - ionotropic and/or chronotropic? |
D1=D2 > B > a
B1 > B2 - just ionotropic. |
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What kind of sympathomimetic is Phenylephrine?
- uses? |
a1 > a2
- pupillary dilation, vasoconstrictoin, nasal decongestion. |
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Metaproterenol?
Albuterol? Salmeterol? Terbutaline? |
All B2 > B1 agonists (B2 selectives)
- acute asthma - acute asthma - chornic tx of asthma - reduce premature uterine contractions. |
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What are 3 indirect sympathomimetics?
- which is used for narcolepsy? - nasal decongestions? - incontinenece? - hypotension? - which causes vasoconstriction and local anesthesia? |
- Cocaine (inhibits reuptake)
- Amphetamine (induces NE release and inhibits reuptake) - Ephedrine (induces NE release) - Amphetamine - Ephedrine - Ephedrine - Ephedrine - Cocaine |
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What effects will the following have on Mean BP, SBP, DBP, and HR? Why?
- NE - Epi - Isoproterenol What is the primary mediator of effect on HR? |
- ^^SBP (B1 effects), DBP (a1 effects) & BP (the mean increases as a result)
+HR decreases because of reflex bradycardia due to a1/a2 effects - ^^SBP (B1 effects), mildly \\DBP (B2 effects), BP means stays ~ normal. +increases HR ~ 100 b/c of B1 effect. - ~SBP (B1), \\DBP (B2) --> Decrease mean BP. +increaes HR superhigh (>100) due to B1 effects. B1 effects. |
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Clonidine
a-methyldopa - class? - use? why? |
centrally acting a2 agonists, \\central adrenergic outflow.
Used to tx HTN b/c they DO NOT decrease RBF. |
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What tumor are Phenoxybenzamine and phentolamine used to tx? Class?
- which should be used before tumor resection? why? - toxicities? |
- Pheochromocytoma; they're a-blockers.
- use Phenoxybenzamine before because it's irreversible. Phentolamine is reversible. - hypotension, reflex tachycardia. |
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things that end in -zosin (Prazosin, terazosin, doxazosin) are what kind of drugs?
- applications? |
a1 selectives.
- HTN, urinary retention in BPH. - 1st dose orthostatic hypotension, dizziness, HA. |
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Mirtazapine is what kind of drug?
- use? - toxicity? - effect on appetitie and chol lvls? |
a2 selective blocker.
- depression - sedation - increases both. |
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Effect B-blockers have on JGA cells?
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DECREASE renin secretion due to blockade of the B-receptors on the cells (b/c usually sympathetic stim upregs renin release)
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Which B-blockers can be used in SVT?
Glaucoma? |
propranolol, esmolol (\\AV conduction velocity).
timolol (\\secretion of aqueous humor) |
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What are the nonselective antagonists of B receptors?
B1 selectives? ** What are the nonselective a- and B- blockers? What are the partial B-agonists? |
propranolol, timolol, nadolol, pindolo, labetalol
"A BEAM of B1 blockers" - Acebutolol (partial agonist), Betaxolol, Esmolol (short acting), Atenolol, Metoprolol carvedilol, labetalol Pindolol (B1 and B2), and Acebutolol (B1) |
