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7 Cards in this Set
- Front
- Back
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Cyclosporine
- mech - clinical use - predisposes pts to what? - tox? preventable w/ what? |
b/cyclophilins --> complex blocks diff and actv of T-cells by inhibiting calcineurin --> prevents production of IL-2 and receptor.
suppresses organ rejection; also used in some autoimmune dz predisposed pts to viral infection and lymphoma nephrotoxic; mannitol diuresis |
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Tacrolimus (FK506)
- mech - clinical use - tox? (lots) |
- like cylosporine. b/FK binding protein --> inhib IL-2 secretion
potent immunosuppressive used in organ transplant recipients Significant tox.... nephro, peripheral neuropathy, HTN, pleural effusion, hyperG |
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Azathioprine
- mech - use - metabolized by - tox |
antimetabolite precursor of 6-MP --> toxic to proliferating lymphocytes
kidney txplt, autoI dz (glomerulonephritis, hemolytic anemia) xanthine oxidase (thus effects might be ^^ by allopurinol) |
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Muromonab-CD3 (OKT3)
- mech - use - tox |
monoclonal Ab b/CD3 on T cells. Blocks cellular interaction w/CD3 that is responsible for TCR signal transduction.
immunosuppression after kidney txplt cytokine release syndrome; hypersensitivity rxn |
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Sirolimus (rapamycin)
- mech - use - tox (3) |
b/mTOR. inhibits T-cell proliferation in response to IL-2
Immunosupp after kidney txplt i/combo with cyclosporin and corticosteroids hyperlipidemia, thrombocytopenia, leukopenia |
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Mycophenolate mofetil
- mech |
inhib de novo guanine synth and block lymphocyte production
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Daclizumab
- mech |
monoclonal Ab w/ high affinity for IL-2 on activated T-cells.
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