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29 Cards in this Set
- Front
- Back
Cardiac glycosides
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Digoxin
|
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Cardiac glycoside
Mechanism |
Direct inhibition Na/K ATPase
Indirect inhibition Na/Ca exchanger Incr Ca intracellular + inotrope |
|
Cardiac glycoside
Use |
Digoxin
CHF - incr contractility A fib - decr conduction AV node |
|
Cardiac glycoside
Toxicity |
Digoxin
Yellow vision, nausea, vomitting Incr PR, decr QT T inversion |
|
Cardiac glycoside
Toxicity worsened by |
Renal failure - decr excretion
Decr K - permits digoxin binding on Na/K ATPase Quinidine -decr digoxin clearance |
|
Class IA antiarrhythmics
3 |
Quinidine
Procainamide Disopyramide Queen Proclaims Disco |
|
Class IA antiarrhythmics
Mechanism |
Na channel blocker
Decr slope phase 4 depolariz'n Slows conduction in depolarized cells --> incr QT interval |
|
Class IB antiarrhythmics
Mechanism |
Na channel blocker
Decr slope phase 4 Slows conduction in depolarized cells |
|
Class IB antiarrhythmics
3 |
Lidocaine
Mexiletine Tocainide Lidy's Mexican Tacos |
|
Class IA antiarrhythmics
Use |
Atrial and ventricular tachycardia
SVT Ventricular tachycardia |
|
Class IB antiarrhythmics
Use |
Acute ventricular arrhythmias post MI
Dig toxicity Best post MI |
|
Class IC
3 |
Flecainide
Encainide Propafenone Flex enkles properly |
|
Class IC
Use |
V tach --> V fib
SVT Contraindicated post MI |
|
Class IC
Mechanism |
Na channel blocker
Decr slope phase 4 Slows conduction in depolarized cells |
|
Class I
Hyper K problem |
Increases toxicity of class I drugs
|
|
Class II antiarrhythmics
Mechanism |
Beta blocker
Decr cAMP, decr Ca current Decr slope phase 4 AV node sensitive --> incr PR interl |
|
Class II antiarrhythmics
5 |
-olol
Propanolol Esmolol Metoprolol Atenolol Timolol |
|
Class II antiarrhythmics
Use |
V-tach
SVT A fib / A flutter. Slow vent'r rate |
|
Class II antiarrhythmics
Toxicity |
Impotence, exacerbation asthma,
Bradycardia, AV block Masks hypoglycemia |
|
Class III antiarrhythmics
5 |
Amiodarone
Sotalol Ibutilide bretyllium Dofetilide |
|
class III antiarrhythmics
Mechanism |
K channel blocker
Incr AP duration Incr ERP (effective refract'y period) Incr QT |
|
Amiodarone
Classes |
I, II, III, IV
Alters the lipid membrane |
|
Class III antiarrhythmics
Amiodarone toxicity |
Amiodarone- contains iodine
--> Hypo / hyperthyroidism, pulmonary fibrosis, hepatotoxic (check PFT, LFT, TFT) Blue-grey skin deposits |
|
Class III antiarrhythmics
Toxicity |
Torsades de Pointes
Excessive beta block |
|
Class IV antiarrhythmics
2 |
Verapamil
Diltiazem |
|
Class IV antiarrhythmics
Mechanism |
AV nodal cells
Decr conduction velocity Incr ERP (effective refracy period) Incr PR interval |
|
Class IV antiarrhythmics
Toxicity |
Flushing, edema
constipation |
|
Class IV antiarrhythmics
Use |
Prevent nodal arrhythmias
Like SVT |
|
Adenosine
|
Incr K out of cells
--> hyperpolarizes cell Used for eliminating SVT Very short acting (15 sec) Blocked by theophylline |