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29 Cards in this Set

  • Front
  • Back
Cardiac glycosides
Digoxin
Cardiac glycoside
Mechanism
Direct inhibition Na/K ATPase
Indirect inhibition Na/Ca exchanger
Incr Ca intracellular
+ inotrope
Cardiac glycoside
Use
Digoxin
CHF - incr contractility
A fib - decr conduction AV node
Cardiac glycoside
Toxicity
Digoxin
Yellow vision, nausea, vomitting
Incr PR, decr QT
T inversion
Cardiac glycoside
Toxicity worsened by
Renal failure - decr excretion
Decr K - permits digoxin binding on Na/K ATPase
Quinidine -decr digoxin clearance
Class IA antiarrhythmics
3
Quinidine
Procainamide
Disopyramide

Queen Proclaims Disco
Class IA antiarrhythmics
Mechanism
Na channel blocker
Decr slope phase 4 depolariz'n
Slows conduction in depolarized cells
--> incr QT interval
Class IB antiarrhythmics
Mechanism
Na channel blocker
Decr slope phase 4
Slows conduction in depolarized cells
Class IB antiarrhythmics
3
Lidocaine
Mexiletine
Tocainide

Lidy's Mexican Tacos
Class IA antiarrhythmics
Use
Atrial and ventricular tachycardia
SVT
Ventricular tachycardia
Class IB antiarrhythmics
Use
Acute ventricular arrhythmias post MI
Dig toxicity
Best post MI
Class IC
3
Flecainide
Encainide
Propafenone

Flex enkles properly
Class IC
Use
V tach --> V fib
SVT
Contraindicated post MI
Class IC
Mechanism
Na channel blocker
Decr slope phase 4
Slows conduction in depolarized cells
Class I
Hyper K problem
Increases toxicity of class I drugs
Class II antiarrhythmics
Mechanism
Beta blocker
Decr cAMP, decr Ca current
Decr slope phase 4
AV node sensitive --> incr PR interl
Class II antiarrhythmics
5
-olol
Propanolol
Esmolol
Metoprolol
Atenolol
Timolol
Class II antiarrhythmics
Use
V-tach
SVT
A fib / A flutter. Slow vent'r rate
Class II antiarrhythmics
Toxicity
Impotence, exacerbation asthma,
Bradycardia, AV block
Masks hypoglycemia
Class III antiarrhythmics
5
Amiodarone
Sotalol
Ibutilide
bretyllium
Dofetilide
class III antiarrhythmics
Mechanism
K channel blocker
Incr AP duration
Incr ERP (effective refract'y period)
Incr QT
Amiodarone
Classes
I, II, III, IV
Alters the lipid membrane
Class III antiarrhythmics
Amiodarone toxicity
Amiodarone- contains iodine
--> Hypo / hyperthyroidism, pulmonary fibrosis,
hepatotoxic (check PFT, LFT, TFT)
Blue-grey skin deposits
Class III antiarrhythmics
Toxicity
Torsades de Pointes
Excessive beta block
Class IV antiarrhythmics
2
Verapamil
Diltiazem
Class IV antiarrhythmics
Mechanism
AV nodal cells
Decr conduction velocity
Incr ERP (effective refracy period)
Incr PR interval
Class IV antiarrhythmics
Toxicity
Flushing, edema
constipation
Class IV antiarrhythmics
Use
Prevent nodal arrhythmias
Like SVT
Adenosine
Incr K out of cells
--> hyperpolarizes cell
Used for eliminating SVT
Very short acting (15 sec)
Blocked by theophylline