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22 Cards in this Set
- Front
- Back
finely branching telangectasias (spider nevi), Fetor hepaticus (dead body breath), gynecomastia, testicular atrophy, asterixis, ankle edema, scleral icterus, juandice, and coma... all can be caused by what?
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Liver cell failure.
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Micronodular liver regeneration (<3mm), uniform... usually due to what types of damage?
Macronodcular (>3mm), varied size? which increases risk of hepatocellular carcinoma? |
metabolic (alcohol, hemochromatosis, Wilson's)
usually due to significant liver injury leading to hepatic necrosis (e.g. posinfectious or drug induced hepatitis). Macronodular. |
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Explain how melana and hematemesis can be signs of portal HTN.
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portal HTN can cause esophageal varices because of the backup circulation trying to relieve HTN. they can then bleed --> sx mentioned.
also, portal HTN can cause PUD, which can go thru the stomach wall and cause the same sx. |
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Which is elevated in MI, AST or ALT?
Alcoholic hepatitis? viral hepatitis? |
AST
AST>ALT ALT>AST |
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What is GGT?
- increased with what? |
gamma-glutamyl transpeptidase)
- various liver diz, also with heavy EtOH consumption. |
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Elevated alk phos can be a result of which type of dz?
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obstructive liver dz (hepatocellular carcinoma), bone dz, or bile duct dz.
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Amylase is elevated in which two types of dz?
- how to tell the difference? |
Acute pancreatitis, mumps
- if lipase is up too, it's probably acute pancreatitis. |
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Lipase is elevated in what?
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acute pancreatitis.
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What does a decrease in ceruloplasmin signal?
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Wilson's dz.
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Hypoglycemia in a child that just had a viral infection (VZV or influenza B especially) that Dr. Mom tx'ed with ASA. Dz?
- histological changes? - mechanism? |
Reye's syndrome.
- mitochondrial abnormalities, fatty liver, coma. - ASA metabolites \\B-oxidation (of fatty acids) by reversible inhibition of mitochondrial enzyme. |
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What is the severity order (and reversibility) of hepatic steatosis, alcoholic cirrhosis, and alcoholic hepatitis?
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steatosis (least severe, reversible)
hepatitis (still might be reversible) cirrhosis (irreversible) |
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AST/ALT is usually > ___ in alcoholic hepatitis?
What is seen on histology? |
1.5
swollen and necrotic hepatocytes with PMN infiltration. Intracytoplasmic eosinophilic inclusions (Mallory bodies) are present. |
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Macrovesicular fatty change in liver due to alcohol is called what?
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hepatic steatosis.
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Micronodular, irregularly shrunken liver w/ "hobnail" appearance is what stage of alcoholic liver dz?
- what would you expect to see on histology and where? - associated sx? |
alcoholic cirrhosis
- sclerosis around central vein (Zone III) - associated with manifestation of chronic liver dz (jaundice, hypoalbuminemia) |
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Pt from Asia presents with jaundice, tender hepatomegaly, ascities, polycythemia, and hypoglycemia.
a-FP lvls are elevated. Dz? - how does it commonly spread in the pt? - why is it common in asia? |
Hepatocellular carcinoma/hepatoma.
- hematologous spread (unlike most carcinomas) - they have more HBV, HCV. |
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Besides HCV and HBV, which other things are risk factors for hepatocellular carcinoma?
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Alcoholics, a1-antitrypsin deficiency, Wilson's dz, hemochromatosis, carcinogens.
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Hepatocellular carcinoma can lead to what syndrome? Why?
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Budd-Chiari syndrome: clinical picture caused by occlusion of the hepatic veins and/or IVC. It presents with the classical triad of abdominal pain, ascites and hepatomegaly.
the cancer can obstruct the hepatic vein! |
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What is Nutmeg liver? causes?
- if the condition persists and you progress... getting centrilobular congestion and necrosis... what is this called? |
liver looks like a mottled nutmed, due to backup of blood. Caused by Right heart failure or Budd-Chiari syndrome.
- cardiac cirrhosis. |
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Absence of JVD, visable back veins, and varices.. .all can be signs of what?
- 3 things associated with it? - eventually leads to? |
Budd-Chiari syndrome.
- hepatocellular carcinoma, pregnancy, polycythemia vera - congestive liver disease (hepatomegaly, ascities, abdominal pain).... --> eventual liver failure. |
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Why does a1-antytrypisn deficiency cause hepatocellular carcinoma? What other sx would you expect?
- what would be seen i/ liver on histo? - type of inheritance? |
misfolded gene product accumulates in hepatocellular ER.
- would see panacinar emphysema. - PAS (+) globules in liver - Codominant trait. |
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At birth, which liver enzyme is immature can lead to jaundice/kernicterus?
- what type of jaundice is this? - tx? |
immature UDP-glucuronyl transferase --> unconjugated hyperbilirubinemia --> jaundice/kernicerus
- phototx converts unconjucated bilirubin to water-soluble form --> gets peed out. |
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Give me the type of hyperbilirubinemia, Urine biliruin, and urine urobilinogen lvls seen i/:
- hepatocellular jaundice - obstructive jaundice - hemolytic |
- conjugated/unconjugated, increased, wnl or decreased (because the liver isn't conjugating much anymore)
- conjugated, increased urine bilirubin, decrease urine urobilinogen - unconjugated, absent (acholuria.. the liver is working fine, it's just doing alot... hence -->) increased urine urobilogen (the normal breakdown product). |