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10 Cards in this Set
- Front
- Back
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What is the rate determining enzyme of the TCA cycle?
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Isocitrate dehydrogenase
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What step of the TCA cylce does Citrate Synthase work in and what is its inhibitor?
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Acetyl CoA--> Citrate
Inhibitor: ATP |
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What are the inducers and inhibitors of Isocitrate Dehydrogenase?
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Inhibitors: ATP and NADH
Inducers: ADP |
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Which enzyme of the TCA cycle catabolizes a-ketoglutarate--> succinyl CoA?
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a-ketoglutarate dehydrogenase
(same cofactors as pyruvate dehydrogenase) |
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What are the irreversible enzymes of the TCA Cylce?
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Citrate Synthase
Isocitrate Dehydrogenase a-KG Dehydrogenase |
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What is the net reaction of the TCA cylce?
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3 NADH, 1 FADH2, 2 CO2, 1 GTP, 12 ATP
This is the net for one Acetyl CoA Everything is 2x for one glucose |
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How do you remember the substrates for the TCA cycle?
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Citrate is Krebs' Starting Substrate For Making Oxaloacetate
Citrate, Isocitrate, a-ketoglutarate, succinyl-CoA, succinate, fumarate, malate, oxaloacetate |
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What can the product oxaloacetate be used for?
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Replenish the TCA cycle
Gluconeogenesis |
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What four pathway products can pyruvate form?
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1. Lactate
2. Acetyl CoA 3. Oxaloacetate 4. Alanine |
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What enzyme is also part of the electron transport chain?
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Succinate Dehydrogenase; Complex II
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