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10 Cards in this Set
- Front
- Back
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What is the purpose of the HMP Shunt?
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provide a source of NADPH from glucose-6-phosphate;
to crease ribose for nucleotide synthesis and glycolytic intermediates |
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How much ATP is used in the HMP Shunt?
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None is used and none is produced
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Where does the HMP shunt take place?
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Lactating mammary glands, liver, adrenal cortex, RBCs
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What is the rate limiting step?
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Glucose-6-P Dehydrogenase
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What is the function of glutathione?
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It is reduced by NADPH so that is can detoxify free radicals
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G6PD Deficiency?
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x- linked recessive
AA hemolytic anemia- Heinz bodies and Bite Cells |
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Where do repiraotry bursts take place?
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Macrophages and Neutrophils
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What is the function of NADPH Oxidase?
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Turns O2 into a free radical;
the first step in the generation of multiple ROI |
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What is Chronic Granulomatous Disease?
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Deficiency in NADPH Oxidase
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What are patients with Chronic Granulmoatous Disease at risk for?
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Pts can still utilize H2O2 as an ROI but catalase positive species neutralize these:
S aureus and Aspergillus |
