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10 Cards in this Set

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  • Back
What is the rate limiting step of glycolysis?
Phosphofructokinase 1
What is Phosphofructokinase 1 induced by?
Fructose 2,6 Bisphosphate
What is the first step of glycolysis?
glucokinase/hexokinase
Glucose--> G-6-P
Requires ATP
Irreversible
Is PFK 1 induced during the fasting or fed state?
Fed state when PFK-2 is most active in forming the inducer F-2,6-BP
What are the inhibitors and inducers of Phosphoglycerate Kinase and what does it catalyze?
Inhibitors: ATP and Alanine
Inducers: F-1,6- BP
1,3 BP Glycerate--> 3PG
What enzyme has the same inducers and inhibitors as Phosphoglycerate Kinase?
Pyruvate Kinase
PEP--> Pyruvate
Irreversible
What are the irreversible steps of glycolysis?
Glucokinase/Hexokinase
Phosphofructokinase
Pyruvate Kinase
Pyruvate Dehydrogenase
What are the inhibitors of Pyruvate Dehydrogenase?
ATP, NADH, Acetyl CoA
What are the 5 cofactors of Pyruvate Dehydrogenase?
1. FAD (B2, riboflavin)
2. Pyrophosphate (B1, Thiamine, TPP)
3. NAD (B3 niacin)
4. CoA (B5, pantothenoate(
5. Lipoic Acid
What metabolic states results with Pyruvate Dehydrogenase deficiency; what are the symptoms; and how do you treat?
Lactic Acidosis
Neurological Defects (Congenital or Acquired- Alcoholism)
Increated Ketogenic Nutrients like Lysine and Leucine