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10 Cards in this Set
- Front
- Back
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What is the rate limiting step of glycolysis?
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Phosphofructokinase 1
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What is Phosphofructokinase 1 induced by?
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Fructose 2,6 Bisphosphate
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What is the first step of glycolysis?
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glucokinase/hexokinase
Glucose--> G-6-P Requires ATP Irreversible |
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Is PFK 1 induced during the fasting or fed state?
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Fed state when PFK-2 is most active in forming the inducer F-2,6-BP
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What are the inhibitors and inducers of Phosphoglycerate Kinase and what does it catalyze?
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Inhibitors: ATP and Alanine
Inducers: F-1,6- BP 1,3 BP Glycerate--> 3PG |
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What enzyme has the same inducers and inhibitors as Phosphoglycerate Kinase?
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Pyruvate Kinase
PEP--> Pyruvate Irreversible |
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What are the irreversible steps of glycolysis?
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Glucokinase/Hexokinase
Phosphofructokinase Pyruvate Kinase Pyruvate Dehydrogenase |
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What are the inhibitors of Pyruvate Dehydrogenase?
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ATP, NADH, Acetyl CoA
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What are the 5 cofactors of Pyruvate Dehydrogenase?
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1. FAD (B2, riboflavin)
2. Pyrophosphate (B1, Thiamine, TPP) 3. NAD (B3 niacin) 4. CoA (B5, pantothenoate( 5. Lipoic Acid |
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What metabolic states results with Pyruvate Dehydrogenase deficiency; what are the symptoms; and how do you treat?
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Lactic Acidosis
Neurological Defects (Congenital or Acquired- Alcoholism) Increated Ketogenic Nutrients like Lysine and Leucine |
