Step 1 Autonomic Drugs Pharmacology

Front 1

Cardiac and Smooth muscle, gland cells, and nerve terminals from MEDULLA

Back 1

Parasympathetic.

Hint 1

First Order Neurons: Ach
Second Order Neurons: Ach, M

Front 2

Sweat Glands

Back 2

Sympathetic.

Hint 2

First Order Neurons: ACh
Second Order Neurons: ACh, M

Front 3

Cardiac and Smooth Muscle, gland cells, nerve terminals

Back 3

Sympathetic.

Hint 3

First Order Neurons: ACh
Second Order Neurons: NE alpha beta.

Front 4

Renal Vascular Smooth Muscle

Back 4

Sympathetic

Hint 4

First Order Neurons: ACh
Second Order Neurons: D, D1

Front 5

Adrenal Medula

Back 5

Release of NE and Epi

Hint 5

ACh

Front 6

Skeletal Muscle

Back 6

Somatic, Voluntary

Hint 6

ACh, N (first order neuron only)

Front 7

Botulinum toxin

Back 7

prevents release of NT at all cholinergic terminals

Front 8

Muscarinic ACh receptors

Back 8

G protein coupled receptors that act thru second messengers. M1, M2, M3, M4, M5

Front 9

Nicotinic ACh receptors

Back 9

Ligand-gated Na/K channels. NN is found in autonomic ganglia and NM are found in neuromuscular junctions.

Front 10

Receptor: alpha 1
Sympathetic
G protein class
Major Functions

Back 10

Receptor: alpha 1
Sympathetic
G protein class: q
Major Functions

Hint 10

Receptor: alpha 1
Sympathetic
G protein class: q
Major Functions: Increase vascular smooth muscle contraction, increased pupillary dilator muscle contraction (mydriasis), increased intestinal and bladder sphincter muscle contraction.

Front 11

Receptor: alpha 2
Sympathetic
G protein class?
Major Functions?

Back 11

Receptor: alpha 2
Sympathetic
G protein class: i
Major Functions

Hint 11

Receptor: alpha 2
sympathetic
G protein class: i
Major Functions: decrease sympathetic outflow, decreased insulin release.

Front 12

Receptor: Beta 1
Sympathetic
G protein class?
Major Functions?

Back 12

Receptor: Beta 1
Sympathetic
G protein class: s
Major Functions

Hint 12

Receptor: Beta 1
Sympathetic
G protein class: s
Major Functions: Increase HR, contractility, renin release, and lipolysis.

Front 13

Receptor: Beta 2
Sympathetic
G protein class?
Major Functions?

Back 13

Receptor: Beta 2
Sympathetic
G protein class: s
Major Functions

Hint 13

Receptor: Beta 2
Sympathetic
G protein class: s
Major Functions: Vasodilation, Bronchodilation, Increased HR, contractility, lipolysis, insulin release. Decreased uterine tone.

Front 14

Receptor: M1
Parasympathetic
G protein class?
Major Functions?

Back 14

Receptor: M1
Parasympathetic
G protein class: q
Major Functions

Hint 14

Receptor: M1
Parasympathetic
G protein class: q
Major Functions: CNS and enteric nervous system

Front 15

Receptor: M2
Parasympathetic
G protein class?
Major Functions?

Back 15

Receptor: M2
Parasympathetic
G protein class: i
Major Functions?

Hint 15

Receptor: M2
Parasympathetic
G protein class: i
Major Functions: Decrease the HR and contractility of atria

Front 16

Receptor: M3
G protein class?
Major Functions?

Back 16

Receptor: M3
Parasympathetic
G protein class: q
Major Functions?

Hint 16

Receptor: M3
Parasympathetic
G protein class: q
Major Functions: Increase exocrine gland secretions, increase gut peristalsis, bladder contraction, bronchoconstriction, pupillary sphincter muscle contraction (miosis), ciliary muscle contraction (accomodation).

Front 17

Receptor: D1
G protein class?
Major Functions?

Back 17

Receptor: D1
Dopamine
G protein class: s
Major Functions?

Hint 17

Receptor:D1
Dopamine
G protein class: s
Major Functions: Relaxes renal vascular smooth muscle

Front 18

Receptor: D2
G protein class?
Major Functions?

Back 18

Receptor:D2
Dopamine
G protein class: i
Major Functions?

Hint 18

Receptor: D2
Dopamine
G protein class: i
Major Functions: modulates transmitter release, especially in brain

Front 19

Receptor: H1
G protein class?
Major Functions?

Back 19

Receptor: H1
Histamine
G protein class: q
Major Functions?

Hint 19

Receptor: H1
Histamine
G protein class: q
Major Functions: increase nasal and bronchial mucus production, contraction of bronchioles, pruritis, and pain.

Front 20

Receptor: H2
G Protein Class?
Major Functions?

Back 20

Receptor:H2
Histamine
G Protein Class: s
Major Functions?

Hint 20

Receptor: H2
Histamine
G Protein Class: s
Major Functions: increase gastric acid secretion

Front 21

Receptor: V1
G Protein Class?
Major Functions?

Back 21

Receptor: V1
Vasopressin
G Protein Class: q
Major Functions?

Hint 21

Receptor: V1
Vasopressin
G Protein Class: q
Major Functions: Increase vascular smooth muscle contraction.

Front 22

Receptor: V2
G Protein Class?
Major Functions?

Back 22

Receptor: V2
Vasopressin
G Protein Class: s
Major Functions?

Hint 22

Receptor: V2
Vasopressin
G Protein Class: s
Major Functions: Increase water permeability and reabsorption in the collecting tubules of the kidney ("V2 is found in the 2 kidneys")

Front 23

Kiss and Kick until your sick of Sex

Back 23

Qiss and Qiq until youre Siq of Sqs.

Front 24

HAVe 1 M&M

Back 24

H1, alpha 1, V1, M1, M3

Hint 24

Gq--> phospholipase C --> PIP2 --> DAG (Protein kinase C) and IP3 (increase intracellular calcium)

Front 25

MAD 2's

Back 25

M2, Alpha2, D2 (Gi)

B1, B2, D1, H2, V2 (Gs)

Hint 25

Adenyl Cyclase (BLOCKED by Gi, ACTIVATED by Gs) ---> ATP to cAMP ---> Protein Kinase A ----> Increased intracellular calcium in heart, decrease myosin light chain kinase in smooth muscle.