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25 Cards in this Set
- Front
- Back
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Secretes mineralcorticoids
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Zona glomerulosa
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Secretes glucocorticoids
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Zona fasiculata
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Secretes androgenic hormones
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Zona reticularis
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What are all hormones derivatives of
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steroids
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Carries cholesterol to the adrenal
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LDL
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What is the pathway of hormone production in the glomerulosa
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pregnenalone
progesterone aldosterone |
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What is the pathway of hormone production in the fasciculata
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prenenalone or progesterone
cortisol |
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What is the pathway of hormone production in the reticularis
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Pregnenalone or progesterone
androstendione |
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Where does aldosterone bind to allow its transport through the blood
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albumin
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Where does cortisol bind to allow its transport through the blood
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transcortin
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Major catabolic hormone in the body
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cortisol
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What will happen to the blood with excess cortisol
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increased protein
increases lipolysis increased blood sugar |
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Increases the effects of other hormone receptors
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cortisol
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Produce catecholamines
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chromaffin cells of medulla
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What is the mechanism for cortisol release and control
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hypothalamus -> CRF
CRF -> anterior pit -> ACTH ACTH-> adrenal -> fasciculata ->cortisol |
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What three things will increase aldosterone release
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Ang 2
Decreased Na Increased K |
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What are the primary functions of aldosterone
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increase Na reabsorption
Increase K secretion |
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What is the secondary function of aldosterone
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increase CL, bicarb, and water reabsorption
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Hypoglycemia, muscle weakness, low BP, dehydration, skin darkening, hypokalemia, mild acidosis
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Addison's
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In Cushing's where is the tumor most likely to be found
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ant. pit > hypothalamus > fasciculata
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Cushing's is a problem of
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too much cortisol
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Tumor of the zona glomerulosa
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Conn's
primary aldosteronism |
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Hypokalemia, metabolic alkalosis, muscle weakness, paralysis, HTN, decreased plasma Renin
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Conn's
primary aldosteronism |
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Abnormal masculizing
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zona reticularis
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What is the order of decreasing potency of glucocorticoids
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dexamethasone > prednisone > cortisol > corticosterone
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