Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
23 Cards in this Set
- Front
- Back
|
Which anti-hypertensive blocks Na+ reabsorption in the distal tubles?
|
Thiazides
Thiazide-like Diuretics |
|
|
Which anti-hypertensive blocks Na+ reabsorption in the ascending loop of Henle?
|
Loop Diuretics
|
|
|
Which anti-hypertensive interferes with the K+/ Na+ exchange in the distal tuble?
|
Potassium Sparing Diuretics
|
|
|
Which anti-hypertensive directly blocks adrenergic stimulation of beta receptors?
|
Beta Blockers
|
|
|
Which anti-hypertensive inhibits the angiotensin converting enzyme from converting angiotensin I to angiotensin II?
|
ACE Inhibitors
|
|
|
Which anti-hypertensive diuretics are ineffective in patients with a CrCl of less than 30mL/min?
What is the exception? |
Thiazides and Thiazide like diuretics
exception: Metolazone (Zaroxolyn) |
|
|
What is the difference between DHP calcium channel blockers and Non-DHP?
|
DHP Calcium Channel Blockers
work on the vasculature and decrease peripheral vascular resistance Anti- Hypertensives NON-DHP work on the myocardium and decrease heart rate and cardiac output Angina/ Arrhythmia |
|
|
How are resins (hyperlipidemia) absorbed and where does metabolism occur?
|
Resins are not systemically absorbed
Metabolized in GI |
|
|
How is Ezetimibe (Zetia) absorbed and where is it metabolized?
|
Zetia is not systemically absorbed
Metabolized in liver and small bowel |
|
|
What is the MOA for Resins?
|
Bind to bile and stimulate liver to convert hepatocellular cholesterol into bile acids.
RESINS/BILE RESINS/BILE |
|
|
What is the MOA for Zetia?
|
Inhibit cholesterol absorption in GI
|
|
|
Zetia is an adjunct for which other hyperlipidemia medication? It interacts on the other hand with?
|
Zetia + Statins = Good
Zetia + Fibrates = Bad |
|
|
How are Resins eliminated?
|
Renal
|
|
|
How is Zetia eliminated?
|
Renal/ Fecal
|
|
|
Which hyperlipidemia medications could cause gall stones and should be avoided with known gall bladder disease?
|
Fibrates
Fibrate/ Stones/ Gall bladder |
|
|
Which two drug classes used to treat hyperlipidemia could also cause heaptotoxicity?
|
Statins
Niacins |
|
|
Which medication class used to treat hyperlipidemia is excreted via the biliary system?
|
Statins
|
|
|
Which medication class used to treat hyperlipidemia can also cause rhabdomyolysis and impotence?
|
Statins
Can impair the production of certain proteins involved in muscle metabolism and function. |
|
|
What is the moa for Statins?
|
Inhibit HMG Co-A reductase
This enzyme is responsible for cholesterol systhesis. STATIN/ STOP SYNTHESIS/ AT NIGHT!!!!!!! |
|
|
Which fruit should statins not be taken with and why?
|
When taken at the same time,
Grapefruits grapefruits can prevent the metabolism of statin, creating accumulation. Accumulation at these levels could lead to liver damage and/or rhabdomyolysis. |
|
|
What is the 1st line of treatment for hyperlipidemia?
|
Statins
They will decrease LDL significantly! |
|
|
What is considered 1st line treatment of isolated hypertriglyceridemia?
|
Fibrates
|
|
|
Which medication for hyperlipidemia treatment can exacerbate peptic ulcer diseae?
|
Niacin
not considered 1st line treatment |
