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6 Cards in this Set
- Front
- Back
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Define the Median Lethal Dose (MLD or LD50)
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Dose which kills 50% of an experimental animal population within specified time after administration.
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Define the Therapeutic Index
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Ratio between LD50 and the ED50.
= LD50/ED50 *larger the ratio the GREATER the margin of safety |
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Define chronic toxicity
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toxic effects which develop only after repeated exposure to a drug for relatively long periods of time
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How and why do allergic rxns to drugs occur?
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patient has been previosuly exposed AND the drug has functioned as an antigen; genetically-determined predisposition
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How do allergic reactions differ from toxic reactions?
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allergic rxns are:
-unrelated to dose -occur only in susceptible person -not related to pharmacological classification of the drug |
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What are Iatrogenic disorders?
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physician induced disorders from lack of knowledge and understanding of a drug;
e.g. corticosteroids > bone degeneration e.g. trifluoperazine > tardive dyskinesia |
